Ragothaman Yennamalli

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a black and white photo of a man in a fur coat standing next to a wolf . ALT: a black and white photo of a man in a fur coat standing next to a wolf .

The @itiscolossal.bsky.social Dire Wolf™ #DeExtinction #DisInformation campaign continues to deceive; GMO grey wolves are not dire ones 🧪 🧟 🐺

This is not funny! 😢 I see this scenario happening soon!🤷‍♂️

New report on navigating challenges of doing science in Global South countries. We often hear about obstacles like bureaucracy and funding constraints. Some practical here on how to navigate

luckily, there are alternatives to PubMed, see libguides.exeter.ac.uk/c.php?g=7252...

Oct 3, 1946: #RosalindFranklin defended her PhD on coal chemistry. That path led to #Photo51—the image that revealed DNA’s double helix. A hidden spark that unlocked life’s blueprint.

🧪

Check out our latest, where we investigate the molecular origin of differences between Lys and Arg and their roles in biomolecular #condensates

@dipcehu.bsky.social

www.biorxiv.org/content/10.1...

She was an inspiration! Rest in peace!

It is way past midnight for me. Will there be a recording?

Drosophila Genetic Database The Drosophila Genetic Database, FlyBase, is on the brink of collapse due to the sudden termination of the FlyBase NIH grant, which includes salaries for 5 literature curators based at the University ...

Flybase lost all of the NIH support overnight - it is a disaster for the community. Please consider donating. I just did! www.philanthropy.cam.ac.uk/give-to-camb...

Autism Scientists Strongly Oppose HHS Report Suggesting Links Between Tylenol and Autism. www.coalitionofautismscientists.org

RFK Jr: “Research on vaccines and autism has been suppressed.”

PubMed: “Here’s over 1200 research papers on vaccines and autism…

…including this first one which is a meta-analysis showing that vaccines are not associated with autism.”

tylenol.com TYLENOL We stand with science, and we stand with you. For generations, families have trusted TYLENOL® when it matters most. Why? Because Tylenol is one of the most studied medications in history. The facts remain unchanged: over a decade of rigorous research, endorsed by leading medical professionals, confirm there is no credible evidence linking acetaminophen to autism. Acetaminophen is used worldwide as a first line of defense for pain relief and fever reduction, at the recommendation of independent public health and leading medical professionals and in accordance with the product label. High fevers and pain are widely recognized as potential risks to a pregnancy if left untreated, especially in the first trimester. Remember to talk to your doctor. We prioritize science as the core of how we provide care, and that will never change.

A pop up box on Tylenol dot com

porto pim bay, faial, açores (own photo, 2025)

yesterday, two tourists chatting on porto pim beach #Faial #Açores
(german) tourist: "ist das kunst oder kann das weg?"
me: "art? nope! just the footwork of a molecular biologist who has spent far too long thinking about circular bacterial chromosomes... by tomorrow, tide or wind have done the job.

Any academic folks on H1B visas (even with stamps in passports) please get legal advice from your University attorneys before leaving the US.

Oxford becomes first UK university to offer ChatGPT Edu to all staff OpenAI’s flagship GPT-5 model will be provided across the University and Oxford Colleges through ChatGPT Edu, a version of ChatGPT built for universities that includes enterprise-level security and

"Oxford becomes first UK university to offer ChatGPT Edu to all staff and students" - imagining a lot of staff there pretty upset about, but also it says much about OpenAI's education strategy that it's targeted Oxford as its first institutional capture in the UK www.ox.ac.uk/news/2025-09...

🚨🚨🚨Finally, the good news is out! Collaborative work with
Dr. Sanhita Roy from LV Prasad Eye Institute, Hyderabad
has been published and online in Journal of Biological Chemistry!!! 🥳🥳🥳Also, this is Ms. Nisha Nandhini Shankar's first paper from the Yennamalli Lab!
Link: www.jbc.org/article/S002...

10 Rules for a Structural Bioinformatic Analysis The Protein Data Bank (PDB) is one of the richest open‑source repositories in biology, housing over 277,000 macromolecular structural models alongside much of the experimental data that underpins thes...

Structural bioinformatics is incredibly powerful on its own or when paired with theory or experiment. One of the PDB's superpowers isn’t from one structure, but comparing many to uncover folds, binding sites, and subtle conformational shifts. chemrxiv.org/engage/chemr...

We’ve put the analysis pipeline and processed data out so others can reproduce or build on it. I’d love to hear what you think, especially from vets, animal geneticists, and immunologists. RTs appreciated. Thanks for reading!

What this means in practice is promising: these genes and pathways are candidates for biomarkers of disease response, targets to explore in vaccine studies, or traits to consider in selective breeding for resilience. But we still need wet-lab validation. 🔬
7/9

Pathway analysis pointed to things you don’t always expect together — necroptosis, osteoclast differentiation, oxytocin signaling, and cGMP–PKG pathways. That mix suggests links between inflammatory cell death, immune signaling, and broader physiological responses.
6/9

we found 28 robustly differentially expressed genes across datasets, and eight of those are clearly immune-related — names you might recognize include IL1A, ZBP1, TLR10, PPARG and others. These aren’t one-off hits; they recur across experiments.
5/9

Why do this? Individual RNA-seq studies are noisy and specific to one experiment. By integrating studies, we cut through that noise and highlight the molecular changes that really matter across conditions.
4/9

We combined four independent bovine transcriptome datasets, reprocessed them through the same pipeline, and then used meta-analysis to pull out genes that are consistently differentially expressed despite different tissues and study designs.
3/9

we ran a meta-analysis of multiple cattle RNA-seq studies to hunt for immune signals that keep popping up across experiments. I’m really excited about what turned up. 2/9

Before we go into the deets. I wish to say that this work was completely done by Vennila and Kishore
(2nd year) in Integrated M.Sc. Data Science course. They wanted to use their data science skills in biological data. 1/9

🚨🚨🚨Preprint Alert!
The work presented by Vennila at #ISMB2025 has now been preprinted in
@biorxiv-bioinfo.bsky.social
🧵 below with the link...

A good resource!

A bear in the wild, smiling and posing coyly

I guess this has probably already gone viral somewhere but I am simply dying at this picture of a bear that looks like it hired a photographer to do a glamour shoot

AI generated review?
Yes, must be an AI generated review. Crazy that this happened.