Ragothaman Yennamalli

vibe coding != blind coding #vibecoding

At the fringes of the BlueSky user galaxy, but in good company!

I am SO incredibly excited to announce the launch of a global list of Inspiring Black Scientists. You can use this list to nominate and connect with researchers. Please share and join us in highlighting these outstanding scientists for #BlackHistoryMonth and beyond!

www.wiley.com/en-us/resear...

Wishing you the best in the next endeavors!!!

For many years, we never had institutional email ids. As a postdoc I had an .edu address, until then I had used my .com address. There are so many institutions on this side of the world where .com addresses are still used for official academic communications by students.

Also, the variant data is available in European Variant Archive. ebi.ac.uk/eva/?eva-stu...

Read our preprint here: bsky.app/profile/bior...

🌱 Why this matters
These results provide a curated set of innate immune gene candidates for:
• Disease-resilient breeding
• Climate-adapted livestock
• Future functional validation
7/8

🔗 Genotype meets function
By integrating PBMC gene-expression data, we show that several immune genes with genomic variants also show distinct basal expression in healthy indicine cattle.

Genomic variation means functional immune readiness.
6/8

🧬 Population genomics tells the story
PCA, FST, dXY, and selective sweep analyses reveal:
• Clear indicine–taurine separation
• Strong immune-gene divergence
• Breed-specific selection signals
Pathogen pressure leaves a genomic signature.
5/8

🧠 Key finding #2
Two innate immune genes stand out:
👉 CARD9
👉 NLRP8

High-impact, indicine-specific variants were found in all four indicine breeds, but were absent in taurine and crossbred cattle.
4/8

This is a genome-wide view of innate immunity. Key Finding #1:
Indicine breeds carry more immune-related variants than taurine and crossbred cattle—
across structural variants, copy-number changes, and high-impact SNVs.

This isn’t just diversity—it’s adaptation.
3/8

We tackle this using integrative whole-genome analysis across indicine, taurine, and crossbred cattle.
📊 Study design at a glance
• >100 animal samples
• 6 breeds (4 indicine, 1 taurine, 1 crossbreed)
• Whole-genome seq
• SNVs, InDels, CNVs, SVs + population genomics
2/8

Fantastic way to start the year 🎉 with a preprint from Yennamalli Lab! This is a ICAR-NASF funded project in collaboration with NDRI, Karnal!
What makes indicine cattle naturally resilient to infections and harsh environments? A 🧵👇🧬 1/8

Prime numbers 2-4999, animated with ggplot2+gganimate.

#Rstats code: gist.github.com/stephenturne...

I would love to be a student in this course!

They smell like heaven!!!

Also @vikasnavaratna.bsky.social there is this: cvit.iiit.ac.in/research/pro...

LOL!!! I will read the paper now more throughly.

How Does India Cook Biryani? A large-scale dataset and VLM-based pipeline for analyzing procedural differences across 12 regional Indian biryani variants using 120 cooking videos.

@vikasnavaratna.bsky.social This is right up your alley! farzanashaju.github.io/how-does-ind...
Haven't read it fully, yet! Sounds interesting...

Thanks and congratulations to you as well for selected as an BPS Ambassdor, Canada! And being in the same cohort!!! 🥳🎉

It is perhaps not hungry enough!😂

I don't see your posts these days. Some algorithm. Missed seeing all these food pics for a long time.

Many congratulations Vikas!

Thanks @madamescientist.bsky.social for the kind words! Much appreciated!

@frettinglab.bsky.social @madamescientist.bsky.social @florencetama.bsky.social @shruthilab.bsky.social

Seventh cohort of BPS ambassadors in Biophysical Society January 2026 bulletin

Way to start the year with a huge humblebrag!
🎉🎉🎉 I have been selected as the Indian Ambassador for @biophysicalsoc.bsky.social seventh cohort (2026-2028)!!! Eagerly looking forward to working with other ambassadors to promote biophysics and bioinfo in India. 🥳 🙌
biophysics.cld.bz/Biophysical-...

📣 Still 11 days to submit proposals for workshops and tutorials for #ECCB2026! Don't miss the opportunity to be an active part of one of Europe's leading conference in #Bioinformatics and #ComputationalBiology.
Deadline: 16 January 2026
🔗 eccb2026.org/call-tutoria...

Congratulations!

Recent Methods from Statistical Inference for Integrative Structural Modeling Integrative modeling of macromolecular assemblies allows for structural characterization of large assemblies that are recalcitrant to direct experimental observation. A Bayesian inference approach fac...

Excited to share our book chapter on method development advances in integrative structural modeling in Springer Handbooks now online! @shreyasarvindekar.bsky.social @kartikmajila.bsky.social doi.org/10.1007/978-...

structbioinfo.bsky.social's Bluesky Wrapped 2025 Check out structbioinfo.bsky.social's year on Bluesky!

This year on Bluesky I wrote 121 posts and 159 replies. I received 303 likes, whereas 27 was from my most popular post, and apparently I love saying "not" and 🚨!

www.madebyolof.com/bluesky-wrap...