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UT Austin Department of Biomedical Engineering

@utbiomedical.bsky.social

Official BlueSky account for the Department of Biomedical Engineering at The University of Texas at Austin.

122 Followers  |  19 Following  |  6 Posts  |  Joined: 20.11.2024  |  1.5343

Latest posts by utbiomedical.bsky.social on Bluesky

Figure 1 from the linked preprint: "OrganoidChip+’s dimensions and principle of work. (a) The chip schematic depicting its height dimensions and various compartments such as the inlet, perfusion channel (PC), culture chamber (CC), trapping areas (TAs) consisting of staging chambers (SCs) and immobilization chambers (ICs), filter channels (FCs), exit chamber (EC), and serpentine exit channel. The serpentine exit channel with a length of 43.5 mm and a width of 215 µm generates a hydrodynamic resistance of 3 × 1012 (N.s/m5) to avoid high flow rates and shear stress inside the chip. (b) Various steps for cell seeding (i), organoid culture (ii), and immobilization (iii) in the chip. (i) For seeding, the Luer stub is inserted into the culture chamber, the cell suspension is dispensed with a rotating movement to fill the entire culture chamber. (ii) Organoids grow efficiently while accessing nutrients from all direction surrounding the culture chamber. (iii) Matrigel is digested, and organoids are pushed into the TAs for immobilization while some organoids are natively immobilized by adhering to the glass in the culture chamber. (c) Side view of the same steps depicted in (b). The organoids in the culture chamber are imaged using brightfield microscopy every day to track their growth. After 7 days of culturing, Matrigel is digested to enable organoid immobilization within TAs. After immobilization, organoids can be fluorescently labelled and imaged at high-resolution on the chip. Scale bars represent 1 mm in (a-b) and 400 µm in (c)."

Figure 1 from the linked preprint: "OrganoidChip+’s dimensions and principle of work. (a) The chip schematic depicting its height dimensions and various compartments such as the inlet, perfusion channel (PC), culture chamber (CC), trapping areas (TAs) consisting of staging chambers (SCs) and immobilization chambers (ICs), filter channels (FCs), exit chamber (EC), and serpentine exit channel. The serpentine exit channel with a length of 43.5 mm and a width of 215 µm generates a hydrodynamic resistance of 3 × 1012 (N.s/m5) to avoid high flow rates and shear stress inside the chip. (b) Various steps for cell seeding (i), organoid culture (ii), and immobilization (iii) in the chip. (i) For seeding, the Luer stub is inserted into the culture chamber, the cell suspension is dispensed with a rotating movement to fill the entire culture chamber. (ii) Organoids grow efficiently while accessing nutrients from all direction surrounding the culture chamber. (iii) Matrigel is digested, and organoids are pushed into the TAs for immobilization while some organoids are natively immobilized by adhering to the glass in the culture chamber. (c) Side view of the same steps depicted in (b). The organoids in the culture chamber are imaged using brightfield microscopy every day to track their growth. After 7 days of culturing, Matrigel is digested to enable organoid immobilization within TAs. After immobilization, organoids can be fluorescently labelled and imaged at high-resolution on the chip. Scale bars represent 1 mm in (a-b) and 400 µm in (c)."

You've heard of #organoids and #organchips, but what about an OrganoidChip+? 🧪

Scientists at @utbiomedical.bsky.social & UGA developed this new, imaging-ready #microfluidic platform for research, drug screening, & disease modeling.

Preprint by Moshksayan et al.
www.biorxiv.org/content/10.1...

27.06.2025 12:27 — 👍 3    🔁 3    💬 0    📌 0
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🎉 Big congrats to Ketsia Z. and Yohan Lee on their exciting research with Professors Pengyu Ren and Jeanne Stachowiak! Their project explores how cells communicate across their membranes using special droplet-like structures made of proteins.

10.09.2025 15:47 — 👍 0    🔁 0    💬 0    📌 0
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Yesterday, Roger Langer, Institute Professor at @mitofficial.bsky.social and leading innovator in biomaterials and biotechnology, presented at the Distinguished Peter B. Dervan Lecture to Texas Engineers, including former classmate, longtime friend and fellow innovator Nicholas Peppas 🤘

17.04.2025 16:31 — 👍 0    🔁 0    💬 0    📌 0
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Big news from @utaustin.bsky.social! #TexasBME is leading an interdisciplinary program uniting top minds across @cockrellschool.bsky.social, @texasscience.bsky.social & @utexaspharmacy.bsky.social— giving Longhorns the tools to revolutionize drug development and delivery. LEARN MORE: bit.ly/43IDovo

12.03.2025 16:55 — 👍 3    🔁 1    💬 0    📌 0
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Big shoutout to #TexasBME senior Jeongwook “Luke” Yun for making The #Austin Business Journal's "Austin Inno Under 25" list! 🎉 Recognized for his innovative work at the intersection of #AI and #healthcare — the future of tech-driven #medicine is bright: bme.utexas.edu/news/5-quest...

05.03.2025 16:58 — 👍 5    🔁 0    💬 0    📌 1
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Magnets Emulate Neurons for Next-Generation Computing In the quest to develop new computing tech — electronics that can think like the human brain — researchers from The University of Texas have made breakthroughs.

Magnets that think? Texas Engineers are pushing the boundaries of computing by developing artificial neurons made of magnetic materials 🧲

Swipe through and tap to learn how these neurons can also keep working for a long time without losing efficiency, a major challenge.

24.02.2025 14:48 — 👍 3    🔁 2    💬 0    📌 1
Biomedical engineering professor Evan Wang in a lab with a researcher.

Biomedical engineering professor Evan Wang in a lab with a researcher.

A new #ultrasound technology developed by researchers from @utaustin.bsky.social can activate #drugs delivered to targeted #cells or parts of the body. Learn more about this #biomedicalengineering #healthcare innovation for #drugdelivery: bme.utexas.edu/news/ultraso...

12.02.2025 14:41 — 👍 3    🔁 1    💬 0    📌 0
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Texas Engineer Magazine Texas Engineer magazine showcases the highest-impact stories from Texas Engineers at the Cockrell School of Engineering.

Hot off the press! Dive into the latest breakthroughs from the @cockrellschool.bsky.social at @utaustin.bsky.social, with expert insights from #TexasBME Professors Pengyu Ren and Samantha Santacruz. Check it out! 🔗 magazine.engr.utexas.edu

15.01.2025 17:11 — 👍 1    🔁 0    💬 0    📌 0

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