Grünewald Lab

EWS::FLI1-DHX9 interaction promotes Ewing sarcoma sensitivity to DNA topoisomerase 1 poisons by altering R-loop metabolism - Oncogene Oncogene - EWS::FLI1-DHX9 interaction promotes Ewing sarcoma sensitivity to DNA topoisomerase 1 poisons by altering R-loop metabolism

EWS::FLI1-DHX9 interaction promotes Ewing #sarcoma sensitivity to DNA topoisomerase 1 poisons by altering R-loop metabolism

www.nature.com/articles/s41...

Subversion of mRNA degradation pathways by EWSR1::FLI1 represents a therapeutic vulnerability in Ewing sarcoma - Nature Communications The EWSR1::FLI1 fusion protein is the oncogenic driver of Ewing sarcoma (EwS). Here, the authors find that EWSR1::FLI1 plays a non-canonical role in mRNA decay via interactions with the CCR4-NOT deade...

Subversion of mRNA degradation pathways by EWSR1::FLI1 represents a therapeutic vulnerability in Ewing #sarcoma

www.nature.com/articles/s41...

Der Wissenschaftliche Vorstand und Vorstandsvorsitzende, Michael Baumann (links im Bild) und der Kaufmännische Vorstand des Deutschen Krebsforschungszentrums, Ursula Weyrich, überreichten gemeinsam den DKFZ-Patienten-Experten-Preis 2025 an Rudolf Hauke. Bild: Uwe Anspach / DKFZ

Der Patienten-Experten-Preis 2025 geht an Rudolf Hauke. 👏 Mit dieser Auszeichnung würdigt das DKFZ sein langjähriges und wegweisendes Engagement für die strukturierte Beteiligung von Patient:innen in der #Krebsforschung. Herzlichen Glückwunsch! @rudolfhauke.bsky.social
t1p.de/wi4zt

Bild: DKFZ

Die Deutsche Forschungsgemeinschaft @dfg.de hat Aurélie Ernst in das Heisenberg-Programm aufgenommen, ein Förderprogramm, das sich an herausragend qualifizierte Wissenschaftler:innen richtet, die ihre Berufbarkeit auf eine Professur nachweisen können. Herzlichen Glückwunsch! 👏

Fabricio Loayza-Puch (links) und Chong Sun Bild: DKFZ/Jung

ERC-Förderung für verbesserte Krebs-Immuntherapien: Fabricio Loayza-Puch und Chong Sun vom DKFZ erhalten schon zum zweiten Mal einen der begehrten "Proof of Concept" (PoC)-Grants. 👏
#ERCPoC @erc.europa.eu

t1p.de/4mg2g

Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature Genetics Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype c...

Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5

cIAP1 inhibitor of apoptosis is a tumor suppressor in Ewing sarcoma Ewing sarcoma (EwS) is a highly aggressive pediatric malignancy driven by EWSR1::ETS fusion oncoproteins -primarily EWSR1::FLI1- which deregulate genes essential for differentiation, proliferation, an...

cIAP1 inhibitor of apoptosis (alias BIRC2) is a tumor suppressor in Ewing #sarcoma

www.biorxiv.org/content/10.1...

@dkfz.bsky.social
@uniheidelberg.bsky.social
@nct-heidelberg.bsky.social

Very excited to have joined the @mpi-ie.bsky.social !
Thank you for the warm welcome 🤩🤩

Congratulations to all @tum.de graduates from Freibierfest Freising - Free Beer Festival Freising 🍻 🎉 🍻

Open positions We are looking for Postdocs! If you are interested in the lab in general as a postdoc, please feel free to apply with an open application, including a letter of motivation and a CV …

We have several open postdoc positions! We do computational biology 🧬🖥️ and deep learning to understand the genomics of genome instability and (somatic) genome evolution in ageing and cancer. Interested? 👉🏻 more details: tu-dresden.de/cmcb/biotec/...

🔥🔥🔥Check out our latest paper on the kidney, wonderful collaboration with Fabian Braun & Christine Kurschat @cecad.bsky.social. Read now: JCI Insight - Loss of genome maintenance is linked to mTOR complex 1 signaling and accelerates podocyte damage insight.jci.org/articles/vie...

Targeting metastasis in paediatric bone sarcomas - Molecular Cancer Paediatric bone sarcomas (e.g. Ewing sarcoma, osteosarcoma) comprise significant biological and clinical heterogeneity. This extreme heterogeneity affects response to systemic therapy, facilitates inh...

This work is the result of a great international collaboration!
Huge thanks to Darrell Green and Emma Bull for bringing together such a strong multidisciplinary team. Check out our review on paediatric bone sarcomas #PaedsOnc #SarcomaResearch

molecular-cancer.biomedcentral.com/articles/10....

Da die @dfg.de ja bis heute in den meisten Verfahren nur zwei Gutachten einholt, bleibt Glück ein sehr wichtiger Faktor bei Entscheidungen - unbefriedigend, seine Karriere darauf zu verwetten!

Comparison of spatial transcriptomics technologies using tumor cryosections - Genome Biology Background Spatial transcriptomics technologies are revolutionizing our understanding of intra-tumor heterogeneity and the tumor microenvironment by revealing single-cell molecular profiles within the...

1/ Spatial transcriptomics technologies are rapidly evolving. We compared five methods—Visium, RNAscope HiPlex, Molecular Cartography, Merscope, and Xenium—and developed technology-agnostic quality control metrics to guide their use: doi.org/10.1186/s130...

How do transcription compartments form — and does phase separation drive gene expression? I enjoyed discussing these questions with @akispapantonis.bsky.social a lot, and we put our thoughts together for @naturerevgenet.bsky.social, now out at rdcu.be/erP1u

Martha from our lab presents her work on how EWSR1::ETS-low cells reprogram tumor metabolism to suppress NK cell activity at the #EuSARC conference in Venice

www.biorxiv.org/content/10.1...

Acquired resistance in cancer: towards targeted therapeutic strategies - Nature Reviews Cancer Acquired therapeutic resistance is a key contributor to cancer treatment failure, requiring new approaches to address its complex mechanisms. In this Roadmap, Soragni, Knudsen and colleagues discuss t...

Acquired resistance limits the efficacy of cancer treatments & accounts for therapy failure in most patients. Our Roadmap explores how innovative technologies bridge the gap between fundamental research on resistance and clinical translation into actionable strategies
www.nature.com/articles/s41...

🔬 New @natcomms.nature.com study by CeMM Adjunct PI @floriangrebien.bsky.social's team at CeMM, Vetmeduni Vienna & @stanna-ccri.bsky.social‬ uncovers how NUP98::KDM5A drives #AML via epigenetic rewiring—identifying CDK12 as a druggable target.
➡️ More: bit.ly/3Hm6dVa
➡️ Paper: go.nature.com/3H8eCM3

Transcriptional and epigenetic rewiring by the NUP98::KDM5A fusion oncoprotein directly activates CDK12 - Nature Communications The epigenetic and transcriptional roles of Nucleoporin 98 (NUP98) fusion oncoproteins in driving pediatric acute myeloid leukemia (AML) remain to be explored. Here, the authors identify a core s...

💡Research team finds CDK12 is a key vulnerability in AML with NUP98 fusions. New hope for targeted therapies in resistant childhood leukemia. Study by Vetmeduni, St. Anna CCRI @floriangrebien.bsky.social & @cemm-vienna.bsky.social in Nature Communications >>> www.nature.com/articles/s41...

Robust statistical assessment of Oncogenotype to Organotropism translation in xenografted zebrafish Organotropism results from the functional versatility of metastatic cancer cells to survive and proliferate in diverse microenvironments. This adaptivity can originate in clonal variation of the sprea...

Robust statistical assessment of Oncogenotype to Organotropism translation in xenografted zebrafish

www.biorxiv.org/content/10.1...

#sarcoma

Targeting metastasis in paediatric bone sarcomas - Molecular Cancer Paediatric bone sarcomas (e.g. Ewing sarcoma, osteosarcoma) comprise significant biological and clinical heterogeneity. This extreme heterogeneity affects response to systemic therapy, facilitates inh...

Targeting metastasis in paediatric bone sarcomas

molecular-cancer.biomedcentral.com/articles/10....

SAVANA: reliable analysis of somatic structural variants and copy number aberrations using long-read sequencing - Nature Methods SAVANA is a tool to detect somatic structural variants and copy number aberrations using long-read sequencing data, offering high sensitivity, specificity and compatibility with or without germline co...

Link to full text (open access) www.nature.com/articles/s41...

Congrats, Chryssie and team!!

EWSR1::ETS-low cells promote metabolic reprogramming of the tryptophan-kynurenine-AHR axis, immunosuppression, and poor outcome in Ewing sarcoma https://www.biorxiv.org/content/10.1101/2025.05.16.654502v1

EWSR1::ETS-low cells promote metabolic reprogramming of the tryptophan-kynurenine-AHR axis, immunosuppression, and poor outcome in Ewing sarcoma https://www.biorxiv.org/content/10.1101/2025.05.16.654502v1

It's been a long journey...but I finally got my board certification for Microbiology, Virology and Infection Epidemiology!
What a fun ride - thanks to all my great mentors at @healthsciences.mcgill.ca 🇨🇦 & @lmumuenchen.bsky.social 🇩🇪!

CCE People Behind: Meet Priya Chudasama Priya Chudasama role in the CCE Rare Tumors Task Force may align perfectly with her background but there’s much more to her CCE journey...

Meet the people behind #CCE! 👩‍🔬 Today’s spotlight is on @priyachudasama.bsky.social from @nct-heidelberg.bsky.social @dkfz.bsky.social, part of CCE’s Rare Tumors Task Force.

Discover more about her CCE journey in this interview👇
www.cancercoreeurope.eu/meet-priya-c...

Frontiers | Highly sensitive live-cell imaging-based cytotoxicity assay enables functional validation of rare epitope-specific CTLs Many immunotherapeutic approaches aim to induce epitope-specific T-cell cytotoxicity. However, the identification—and especially the functional validation—of...

🧬 New Paper out!
Kathrin Wellach and Angelika Riemer from our department published a new highly sensitive cytotoxicity assay using live-cell imaging. With this method, epitope-specific T cells can be functionally analyzed for their cytotoxic capacity!

📄 Check it out: tinyurl.com/cytotoxicity...

Not long after I started my lab, a prominent scientist told me it was “impossible” to be a successful PI and a mother

Don’t ever let the naysayers tell you it can’t be done - of course it can!

#HappyMothersDay this weekend to all the amazing scientist mamas raising their wonderful kids 🥰

Very proud on our team for winning the Gold Medal of the LEAF program for improving sustainability practices