The Brigant Lab

🎥Access the #EULAR2025 Congress on-demand and watch inspiring Scientific Sessions from Monday 16 June until 31 December 2025!

Registration deadline: 30 June 2025, 23:59 CEST

Register here: https://pulse.ly/onsw7zxrcf

#Rheumatology #EULAR

Hi, these are screenshots from the conference. Do you want the patchwork we shared or all the screenshots? (Dav)

Fatigue has a considerable impact on the daily lives of people living with RMDs and their families #eular2025

@karinasturm.bsky.social Thanks again for our interesting exchange (Benjamin)!

Yesterday at #EULAR2025, we explored Ehlers-Danlos syndrome (EDS): its diagnosis, pathways, therapies, and comorbidities. Inspiring insights into this complex condition! 🦓🌍💡✨ #EULAR2025 #EDS #ehlersdanlossyndrome #rheumaticdiseases #brigantlabonthemove #BehindBrigantLab #MedSky #AcademicSky

Yesterday at #EULAR2025, we explored Ehlers-Danlos syndrome (EDS): its diagnosis, pathways, therapies, and comorbidities. Inspiring insights into this complex condition! 🦓🌍💡✨
#EULAR2025 #EDS #ehlersdanlossyndrome
#rheumaticdiseases #brigantlabonthemove #BehindBrigantLab #MedSky #AcademicSky

Anna Fryxelius, a woman in a wheelchair is smiling and pointing enthusiastically at a scientific poster behind her. The poster, titled “Structured patient involvement in Rheumatoid Arthritis research,” is presented by the Norwegian Rheumatism Association (Norsk Revmatikerforbund) at the EULAR Congress. It highlights the top 10 unanswered research questions in rheumatoid arthritis and describes a James Lind Alliance priority-setting process. The woman is wearing a black suit and conference badge, and the setting is a professional blue-carpeted conference hall.

🧪✨ Proud to represent Norsk Revmatikerforbund at #EULAR2025 with four posters on patient-led research!

Here with poster #1 - presenting at A08 at 15:30 today 😃

🔹 Poster 1: Top 10 research priorities in Rheumatoid Arthritis – identified through a participatory James Lind Alliance process:

Hello from EULAR 2025! 🏛️✨ Ready to explore, connect, and learn in Barcelona. 🌍🔬 #EULAR2025 #BrigantLab #ScienceInBarcelona #osteoarthritis #MedSky #AcademicSky

Hello from EULAR 2025! 🏛️✨ Ready to explore, connect, and learn in Barcelona. 🌍🔬
#EULAR2025 #BrigantLab #ScienceInBarcelona #osteoarthritis #MedSky #AcademicSky

Gratulerer med dagen for 17 mai ! 🇳🇴🎊✨

🌟 Inside Brigant Lab : The chondrocytes cells 🌟 Have you ever wondered how aging cells contribute to joint damage? Let’s dive into the science together! 🧠💡 Meet the chondrocytes, the architects of cartilage health, maintaining its structure and function. But in osteoarthritis (OA), their balance is disrupted. These cells start contributing to cartilage breakdown, driving joint degeneration. As they age, chondrocytes lose their ability to repair cartilage and produce proteins that accelerate its destruction—worsening joint damage and fueling the progression of OA. Understanding their role is key to unlocking new treatments. 🧬🦴✨ Image: Chondrocyte cells in 2D culture Want to know more? Stay tuned for more #InsideBrigantLab posts, where we’ll share insights into our research and an exclusive preview of what’s next in our scientific journey. 🔍 #CellularBiology #chondrocyteresearch #osteoarthritis #science #research #ArthritisAwarenessMonth #MolecularMedicine#sciencecommunication#lablife #brigantlab #insidebrigantlab

#InsideBrigantLab How do aging cells drive joint damage?🤔
In osteoarthritis, chondrocytes lose their repair abilities and release proteins that accelerate cartilage breakdown, fueling joint degeneration. 🦴

Stay tuned for more insights ! 💡 #MedSky #AcademicSky #cellularbiology #BrigantLab

🌟 Welcome to InsideBrigantLab! 🌟 In this series, we’ll take you behind the scenes of our lab’s journey to advance diagnostics and develop innovative treatments for rheumatologic diseases.🔬💊📖 Our first feature focuses on Osteoarthritis (OA), the most common form of arthritis—a condition that wears down joint cartilage over time. Think of cartilage as the cushion between your joints. In OA, that cushion wears thin, leading to pain and stiffness. OA affects millions worldwide and significantly reduces quality of life. 🦴♿ Did you know that by 2050, 1 in 3 people may be living with OA? Understanding its symptoms, prevalence, and the current limitations in treatments is crucial for driving innovative research. 💡 While prevention strategies exist, effective disease-modifying treatments remain a significant unmet need—and this is where our work comes in. At BrigantLab, we’re diving deep into the molecular mechanisms of OA, with a special focus on the role of chondrocytes and connective tissues.🧬🩺 Stay tuned for more #InsideBrigantLab posts, where we’ll share insights into our work, the impact we strive to create, and an exclusive preview of what’s next in our scientific journey. Have questions or topics you’d like us to explore? Let us know! 😊 #osteoarthritis #osteoarthritisawareness #rheumaticdisease #chondrocyteresearch #molecularmedicine #research #sciencecommunication #BrigantLab #InsideBrigantLab

👀 Curious about what happens at Brigant Lab?

Follow our new series: #InsideBrigantLab!

Explore our research, discoveries, and beyond. 🧬💡😃

#osteoarthritis #AcademicSky #MedSky #Science #Research #lablife #InsideBrigantLab

💚 May is Arthritis Awareness Month! 💚 Arthritis Awareness Month is a global initiative to raise awareness about the impact of rheumatic and musculoskeletal diseases (RMDs), which affect millions of lives worldwide. 🌍 At Brigantlab, we’re shining a light on osteoarthritis (OA)—a common form of arthritis that impacts joints like the knees, hips, and hands. For those living with OA, chronic pain, stiffness, and reduced mobility are daily challenges.🦵🤲 For over 500 million people, OA means chronic pain, stiffness, and reduced mobility, but together, we can make a difference. 💥 🔬 Our research dives deep into how chondrocytes (the cells in cartilage) respond under pathological conditions. With every discovery, we’re closer to better diagnosis, treatments, and hope for those affected.🧬 Let’s remember: ✅ OA doesn’t discriminate—it can affect anyone, at any age. ✅ It’s life-changing, but through awareness and innovation, we can fight back. ✅ Research is the key to unlocking a better future. Join us this month to raise awareness and support advancements in arthritis research. Together, we can take steps toward a pain-free future! 🔥💚✨ #arthritisawarenessmonth #supportarthritis #EULAR #eularadvocacy #osteoarthritis #osteoarthritsawareness #chondrocyteresearch #scienceforchange #research #brigantlab

May is #ArthritisAwarenessMonth A global initiative to highlight the impact of rheumatic & musculoskeletal diseases. At Brigantlab, we're advancing osteoarthritis research to improve lives. Join us in spreading awareness and hope.💚 #Osteoarthritis #RheumaticDiseases #MedSky #AcademicSky #BrigantLab

🚨 Exciting Research Update! 🚨 We’re thrilled to announce the publication of an important and exciting study in Non-Coding RNA Research where BrigantLab was part ! 🎉 We reveal a strong link between uremic toxin levels and the microRNA miR-223 in chronic kidney disease (CKD)-associated anemia. We demonstrated that the uremic toxin indoxyl sulfate (IS) increases miR-223 expression in both human erythroid cell lines and primary cells. In a cohort of over 500 CKD patients, serum miR-223 levels correlated with IS and other uremic toxins, as well as with markers of endothelial dysfunction and anemia severity. 🧬 Why is this important? These findings position miR-223 as a promising biomarker for monitoring CKD-related anemia and vascular complications—opening the door to more personalized and non-invasive diagnostic strategies. 💡 A huge congratulations to Laurent Metzinger for spearheading this important work, and to all the incredible co-authors: Emma Brisot, Pierre-Marie Leprêtre, Eya Hamza, PhD, MBA, Ophelie Fourdinier, Hakim Ouled-Haddou, Gabriel Choukroun, Ziad Massy, Francis Verbeke, Valérie Metzinger-Le Meuth, and Griet Glorieux! ✨ 🔗 Read the full article here: https://doi.org/10.1016/j.ncrna.2025.04.009 [or link in bio] 📖 Stay tuned for more updates from BrigantLab ! 🚀 #ckd #chronickidneydisease #chronickidneydiseaseawareness #anemia #BiomarkerDiscovery #mir223 #uremictoxins #nephrology #Research #Researchpapers #science #lablife #brigantlab

Proud to be part of this new study on uremic toxins & miR-223 in CKD anemia.
🔗Check it:https://doi.org/10.1016/j.ncrna.2025.04.009

#ckd #nephrology #MedSky #AcademicSky #Science #Research #BrigantLab

👋🔬 "Behind the BrigantLab" series - Meet the Minds Behind BrigantLab! Today, let's spotlight Dr. Benjamin Brigant, researcher at NTNU in Trondheim, co-founder and a driving force of BrigantLab ! Currently based at the Norwegian University of Science and Technology (NTNU) in Trondheim, Benjamin brings over 9 years of expertise in molecular and cellular biology to the forefront of our research. 💡 His journey spanned studying studying microRNAs in France (UPJV), pioneering CRISPR-Cas13 RNA targeting in Canada (UoA, Alberta), and exploring CD5L in Norway (NTNU). Now, at BrigantLab, Benjamin’s work bridges his diverse experiences in inflammation and cartilage biology. His focus includes osteoarthritis, joint disorders, and rare genetic conditions like MULIBREY nanism and Ehlers-Danlos Syndrome, with a special emphasis on joint, cartilage, and inflammation abnormalities. 🧬💪 🌍 His passion for discovery is matched only by his enthusiasm for connecting ideas across disciplines—whether in the lab or at collaborative works. ✨ Fun fact: When he’s not in the lab, you might find him hitting the snow ❄️ and cross-country skiing 🎿 during the winter months! 👉 Follow us for more behind-the-scenes moments, research updates, and a peek into life at BrigantLab! 🦓 Don’t forget, you can support our latest project: https://gofund.me/15cbe96b 🔗 Visit our Linktree in bio to learn more! #BehindBrigantLab #meettheteam #brigantlab #science #research #supportscience #lablife #skiingscientists

👋🔬 Behind BrigantLab: Meet co-founder Dr. Benjamin Brigant (NTNU)! 9+ yrs in molecular bio, from France to Norway. Focus: rare genetic conditions, osteoarthritis & more. Cross-country ski lover! ❄️ Follow our science journey! ➡️ [Linktree in bio]
#AcademicSky #MedSky #lablife #BehindBrigantLab

Wonder what happens at BrigantLab?🤔
▶️ Exploring the molecular roots of osteoarthritis & genetic diseases like EDS. From lab to clinic, bringing hope! 🧬🔬💫
🔗 Support us via Linktree in bio!

#molecularbiology #osteoarthritis #EDS #AcademicSky #MedSky #lablife #InsideBrigantLab

For me (Davina) it took around 15 years. Like you, symptoms had been around since childhood but wasn't heard. Even now, it's a battle to receive appropriate care where I live now, while some symptoms worsen ... Even with more knowledge, it's still complicated...
Thank you for sharing your story🦓🩵💫

Thank you so much for your support and repost 💫💫💫

Thank you. We make the changes. Hope without mistakes 😅

Thank you for being part of the journey. Your support means the world to us. 💫

💡 Let’s pave the way of hope together — for better diagnosis, better care, and better futures.

👉 We just launched our crowdfunding campaign and need YOUR help to make this possible. Whether you can donate, share, or simply spread awareness, you’re already part of this journey.

🧬 This project is fueled by real stories, real struggles — and the hope that science can bring change.

For too many, the journey to a diagnosis takes 10+ years, filled with doubt, misdiagnoses, and invisible suffering. We believe people living with EDS deserve better. That’s why our team is working to discover biomarkers that can make diagnosis faster, fairer, and more accurate. 🔬❤️

Today, we’re proud to launch a research project dedicated to improving the diagnosis of Ehlers-Danlos Syndrome (EDS) — a group of rare and often misunderstood connective tissue disorders that affect millions around the world. 💔

🌟 After a few weeks of silence, we're thrilled to finally share something close to our hearts — the latest project from Brigant Lab, and it needs your support.

Hi everyone! 🌟 After a few weeks of silence, we're thrilled to finally share something close to our hearts — the latest project from Brigant Lab, and it needs your support. 🎉 We’re Launching: “Paving the Way of Hope” 🦓💫 Today, we’re proud to launch a groundbreaking research project dedicated to improving the diagnosis of Ehlers-Danlos Syndrome (EDS) — a group of rare and often misunderstood connective tissue disorders that affect millions around the world. 💔 For too many, the journey to a diagnosis takes 10+ years, filled with doubt, misdiagnoses, and invisible suffering. We believe people living with EDS deserve better. That’s why our team at the Brigant Lab (NTNU, Norway) is working to discover biomarkers that can make diagnosis faster, fairer, and more accurate. 🔬❤️ 🧬 This project is fueled by real stories, real struggles — and the hope that science can bring change. 👉 We just launched our crowdfunding campaign and need YOUR help to make this possible. Whether you can donate, share, or simply spread awareness, you’re already part of this journey. 💡 Let’s pave the way of hope together — for better diagnosis, better care, and better futures. 🔗 https://gofund.me/15cbe96b Thank you for being part of the journey. Your support means the world to us. 🤍 #Pavingthewayofhope#eds#ehlersdanlossyndrome#ehlersdanlossyndromeawareness#chronicillness#invisibledisability#edscommunity#raredisease#zebrastrong #genetics#medicalresearch#crowdfundingscience#supportresearch#supportscience#researchers#lablife #BrigantLab

Help us speed up EDS diagnosis! 🦓 Brigant Lab's biomarker research aims for faster, fairer answers. 💥

🔗 gofund.me/15cbe96b

Your support (donations, shares, kind words) means the world! Thank you! 💖✨
#EDS #ehlersdanlossyndrome #MedSky #Zebras #InsideBrigantLab

👉 We just launched our crowdfunding campaign and need your help to make it happen.
💥 Donate, share, or spread the word — every action brings us closer to better care.

💡 Let’s pave the way of hope together — for better diagnosis, better care, and better futures.

⏳ For too many, the road to diagnosis takes 10+ years — filled with doubt, misdiagnoses, and invisible suffering. People with EDS deserve better.
That’s why our team at Brigant Lab (NTNU, Norway) is working to identify biomarkers that can make diagnosis faster, fairer, and more accurate. 🔬❤️

After weeks of silence, we’re proud to kick off a research project dedicated to improving diagnosis for Ehlers-Danlos Syndrome (EDS) — a group of rare and often misunderstood connective tissue disorders affecting millions. 💔

We place patients at the heart of our research, striving to translate scientific breakthrough into tangible improvements of their quality of life. ❤️

✅ Exploring complications and associated mechanisms, such as inflammation, that contribute to disease progression
✅ Developing innovative therapeutic strategies to address these conditions