Michal Caspi Tal, PhD

#MicroSky: Clinical Treatments: In Crohn’s disease, gut bacteria may shape response to biologic therapy. Patients with more Fusobacterium were less likely to improve on ustekinumab, hinting that the microbiome could help predict who benefits most. Read Wang et al. doi.org/10.1111/1751...

The Long COVID Treatment Trial – Tirzepatide (LoCITT-T) is officially open for enrollment for people with Long COVID in:
Alabama, Alaska, California, Florida, Illinois, Indiana, Michigan, Ohio, Pennsylvania, Texas, Utah
longcovid.scripps.edu/locitt-t/?ut...

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GitHub - aqlaboratory/openfold-3: OpenFold3: A fully open source biomolecular structure prediction model based on AlphaFold3 OpenFold3: A fully open source biomolecular structure prediction model based on AlphaFold3 - aqlaboratory/openfold-3

Looks like OpenFold3 has been formally released in a public "preview". Not quite on parity with AlphaFold3 on a few benchmarks shown, in particular for antibody interactions. All info on the github link. I am sure we will hear more about this from the developers github.com/aqlaboratory...

Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold.

Want to get a tough sample, like lung, looking like this? Read more!

www.biorxiv.org/content/10.1...

1/ This is my first time posting a comment on a bioRxiv manuscript, but since I've been asked my opinion on this one a bunch, and I was actually one of the reviewers and waived my anonymity in review, I decided to post my review as a comment: www.biorxiv.org/content/10.1...

2/ The TL/DR is that I think this paper is both very informative, and very important. However, it needs to be contextualized as a deep study of blood from a recovery cohort, which is then being compared to public data from tissue from cohorts where many did not recover.
Add your comments to discuss

1/ This is my first time posting a comment on a bioRxiv manuscript, but since I've been asked my opinion on this one a bunch, and I was actually one of the reviewers and waived my anonymity in review, I decided to post my review as a comment: www.biorxiv.org/content/10.1...

It should be noted that Google has noticed the backlash enough that they quietly published a code that would removed AI results for their searches.

An enterprising person built a default site to search without AI, and the results are goddamn refreshing as hell.
udm14.org

Half of Heart Attacks in Younger Women Aren't From Clogged Arteries Traditionally, most heart attacks have been blamed on clogged arteries causing atherothrombosis – where blood clots block flow to the heart.

Sex differences matter!
www.sciencealert.com/half-of-hear...

Epstein–Barr virus exploits desmocollin 2 as the principal epithelial cell entry receptor | @natmicrobiol.nature.com

sco.lt/6i4kd6

My cousin died from a vaccine preventable illness, and that's part of why it's so important to me to work on the immunology of infectious disease. I know what's on the line.

Post about my decision to vaccinate my baby ahead of schedule during a measles outbreak

What if this was your kid, you ask? I'll tell you. As an infectious disease immunologist, I protect my kids through vaccination. A measles outbreak reached my county when I had an infant. Knowing the risk for severe outcomes, I read the literature, vaccinated him EARLY and then rejoined the schedule

YouTube video by MicrobeTV Immune Booster #2: Sex differences in immune responses with Michal Tal

Immune Booster 2: Sex differences in immune responses with Michal Tal

YouTube video by MicrobeTV Vaccines save lives

"If you're not vaccinated...there may not be any time."-Michal Tal

From Immune Booster 2: Sex differences in immune responses with Michal Tal (@immunofever.bsky.social )

Hosts:
@cindyleifer.bsky.social @bioprofbarker.bsky.social

Doubling down as a Toxicologist. The benefits far outweigh the harms.

Linking to my full post from that time when I was faced with a measles outbreak with a kid that was below the recommended age for MMRV. I'm so sorry for the parents who will lose access to lifesaving vaccines for their babies.

Post about my decision to vaccinate my baby ahead of schedule during a measles outbreak

What if this was your kid, you ask? I'll tell you. As an infectious disease immunologist, I protect my kids through vaccination. A measles outbreak reached my county when I had an infant. Knowing the risk for severe outcomes, I read the literature, vaccinated him EARLY and then rejoined the schedule

The only question now is what huge problem do YOU (reader) want to address with this incredible data set? The world's sequences are your oyster. Go make pearls!

🌎👩‍🔬 For 15+ years biology has accumulated petabytes (million gigabytes) of🧬DNA sequencing data🧬 from the far reaches of our planet.🦠🍄🌵

Logan now democratizes efficient access to the world’s most comprehensive genetics dataset. Free and open.

doi.org/10.1101/2024...

Earth’s genetic diversity is a heritage of humanity. It has been an honour to explore this data with a team of dedicated scientists who shared our vision of making this data free and accessible to all 🌍🧬❤️ Thank you!

Updated preprint: doi.org/10.1101/2024...

All Logan data is freely-available (cc0) right now. We show how Logan-Search (www.logan-search.org) can be used to uncover viral reactivation (HHV-6) in cell therapy products (TIL and CAR-T).

An illustration from JAMA's review on adrenal insufficiency, dated June 16, 2025, showing normal and impaired hypothalamic-pituitary-adrenal axis physiology with mechanisms leading to adrenal insufficiency.

Adrenal insufficiency is a syndrome of cortisol deficiency.

This Review summarizes the pathophysiology of adrenal insufficiency and approaches to diagnosis, treatment, and prevention of adrenal crisis.

ja.ma/3HKk9Jr

Opinion | We Ran the C.D.C.: Kennedy Is Endangering Every American’s Health

9 CDC Directors going back to 1977 speak out. What RFK Jr has done to our nation’s public health system "should alarm every American."

It "is unlike anything we have ever seen at the agency, and unlike anything our country has ever experienced." www.nytimes.com/2025/09/01/o...

Frustrated little dude gripping a pencil saying “how do I pack this down into something I can actually share?” While swirling rainbows labeled “INFINITE POTENTIAL” float around them. Little dude frowns at a tiny grey box, exclaiming “all that work for THIS?!” Little dude shoves the grey box into another little guy’s hands; Frowning, stomping off, and saying “Here you go, I made this, it sucks.” Second little dude cracks open the box, swirling rainbows project out onto their face. Second little dude stares in awe at all the swirling rainbows now floating around them.

Sometimes we’re unsatisfied with a thing we made because when it only existed in our head, we saw all the things it could have been and when it’s done we know all the things that it isn’t, but we can’t see the way it expands into a million new things when someone else unpacks it in their head. 🖊️🦑

Paris said au revoir to cars. Air pollution maps reveal a dramatic change. Air pollution fell substantially as the city restricted car traffic and made way for parks and bike lanes.

“Over the past 20 years, Paris has undergone a major physical transformation, trading automotive arteries for bike lanes, adding green spaces and eliminating 50,000 parking spaces.

Part of the payoff has been invisible — in the air itself.”

Leadership, strategy, real action, common sense. #Paris

The CDC quietly scaled back a surveillance program for foodborne illnesses As of July 1, a critical surveillance program is monitoring for only two pathogens instead of the usual eight.

A federal-state partnership that monitors for foodborne illnesses quietly scaled back its operations nearly two months ago.

As of July 1, the critical surveillance program is monitoring for only two pathogens instead of the usual eight, a spokesperson for the CDC says.

The year I was born. we basically had no idea why cancers happened and now we understand the underlying force behind it with 100% clarity and the molecular forces behind it with many orders of magnitude more resolution.

We were entirely in the dark, and now the room is lit.

Need for awareness and surveillance of long-term post-COVID neurodegenerative disorders. A position paper from the neuroCOVID‐19 task force of the European Academy of Neurology

Important paper by members of the European Academy of Neurology. "Healthcare systems should be aware of, and be prepared for a potential increase in the incidence of neurodegenerative diseases in the upcoming years." What has been the state of surveillance and awareness so far? #NeuroCovid

Shared Immune and Epigenetic Pathways in Systemic Lupus Erythematosus and Melanoma Immunotherapy: A Cross-Disease Analysis with Prognostic and Therapeutic Implications https://www.biorxiv.org/content/10.1101/2025.08.19.671053v1

@biorxivpreprint.bsky.social Pediatric long COVID Is characterized by myeloid CCR6 suppression and immune dysregulation @sarmoronlo.bsky.social
www.biorxiv.org/content/10.1...