Matt Saucier

@cathleencrudden.bsky.social

Asymmetric Diamination of the In Situ Generated Difluoroenol Species Using Azocarboxamides as an N Source The Rh2(esp)2 and Zn(II)-bisoxazoline (BOX) complex-cocatalyzed asymmetric diamination of in situ generated difluoroenol species with azocarboxamides has been disclosed. This reaction features a formal [3 + 2]-cycloaddition reaction using difluoroenol intermediate as a C2 synthon, providing an efficient and robust approach for the synthesis of difluorinated imidazolidin-2-ones in good yields with high to excellent stereoselectivity (up to 95% ee). This method offers a complementary approach for the direct assembly of chiral difluoromethylene incorporated heterocycles by introducing in situ formed difluoroenol species as a practical C2 synthon rather than using presynthesized gem-difluoroalkenes. With this protocol, further synthetic applications in fluorine chemistry could be envisioned through the strategic interception of difluoroenol via cycloaddition reactions with appropriate partners.

Check out this CF2 synthon enabled by dual Rh-Zn catalysis in #ACSCatalysis #EditorsChoice

pubs.acs.org/doi/10.1021/...

@cathleencrudden.bsky.social

Sponsored by: @organicdivision.org , @pubs.acs.org

Submit your nominations for the ACS Catalysis Lectureship Award by Dec 31!

The award winner will receive:
- $1000 USD prize
- Complimentary travel and registration to ACS Fall 2026 in Chicago to deliver the award lecture
- Award plaque

americanchemical.co1.qualtrics.com/jfe/form/SV_...

Sponsored by: @organicdivision.org & @pubs.acs.org

Nominate Articles for the #OPRD 2026 Outstanding Paper of the Year Award by Dec 31!

The award winner will receive:
- $2000 USD prize
- Complimentary travel and registration to ACS Fall 2026 in Chicago to deliver the award lecture
- Award plaque

americanchemical.co1.qualtrics.com/jfe/form/SV_...

Sponsored by: @organicdivision.org & @pubs.acs.org

Sponsored by: @organicdivision.org & @pubs.acs.org

Nominate Letters for the #OrgLett 2026 Outstanding Paper of the Year Award by Dec 31!

The award winner will receive:
- $2000 USD prize
- Complimentary travel and registration to ACS Fall 2026 in Chicago to deliver the award lecture
- Award plaque

americanchemical.co1.qualtrics.com/jfe/form/SV_...

🚨Special Issue Alert🚨

π-Conjugated Molecules & Materials in #OrgLett

Honoring August Kekulé and Eric Clar, this Special Issue showcases everything from CPL and optoelectronics, to nonbenzenoid aromatic compounds and nanohoops.

pubs.acs.org/page/orlef7/...

Apply to attend ACS150 JACS Symposium Series: ETH Zürich - Expanding Horizons of Nanoscience & Energy ETH Zurich, Switzerland 12-13 January 2026

Upcoming: ACS150 JACS Symposium: Expanding Horizons of Nanoscience & Energy

Celebrating 150 years of ACS and chemical discovery with two days of cutting-edge science in nanoscience and energy.

📍 @ethz.ch, Switzerland
📅 12-13 January 2026

Apply to attend: buff.ly/wwbZ5c6

[3 + 2] Annulation of Donor–Acceptor Cyclopropanes with Ammonium Thiocyanate: Interrupted Cascade Leads to Elusive Iminodihydrothiophene Derivatives A zinc iodide-mediated [3 + 2] cyclization between donor–acceptor cyclopropanes and ammonium thiocyanate has been developed to afford 2-imino-tetrahydrothiophene derivatives under mild conditions. Sub...

Another #EditorsChoice article published in #JOrgChem! Learn more about cyclopropane annulation to form elusive iminodihydrothiophene derivatives from Maity and co-workers

pubs.acs.org/doi/10.1021/...

A Simplified, One-Pot, Procedure for the Deoxygenative Alkylation of Aryl Bromides Advancements in the field of C(sp2)–C(sp3) cross-coupling using alcohols as feedstocks have resulted in widespread adoption in analogue synthesis. Using high-throughput experimentation, an in situ alc...

Editors' Choice alert! Plunkett, et al. in #OrgLett: A Simplified, One-Pot, Procedure for the Deoxygenative Alkylation of Aryl Bromides

pubs.acs.org/doi/10.1021/...

Congrats and thanks to Neil Garg, Ralph Zhao, and co-workers for publishing #OrgLett 's first Safety Letter: Evaluation of the Popular Oxidant 2-Iodobenzoic Acid (IBX)

pubs.acs.org/doi/10.1021/...

Emphasizing Safety in Publications at Organic Letters: The Safety Letter

Conducting impactful research for the betterment of the world and our society ought not to be overshadowed by the dangers and risks its practitioners take on. -- Read about our Safety Letter initiative at #OrgLett

pubs.acs.org/doi/10.1021/...

"Failure is the mother of success" -- Read case studies highlighting the knowledge gained from failures and unexpected results in this Lessons Learned in Organic Process Chemistry Special Issue in #OPRD @pubs.acs.org

pubs.acs.org/page/oprdfk/...

Photo-Catalyzed Synthesis of Indanones from Aromatic Aldehydes and Terminal Alkynes Indanones are key structural motifs in pharmaceuticals and bioactive natural products, making their efficient synthesis a subject of continued interest. Conventional methods typically rely on transiti...

Read about this new photocatalyzed cyclization and HAT reaction published in #JOrgChem by Ghosh/Konig and coworkers. Selected for #EditorsChoice

pubs.acs.org/doi/10.1021/...

NSF-funded reproducibility in homogeneous catalysis workshop coming Jan 2026. Check out the webinars coming up on Oct 22 and 29 with ACS Catalysis EIC Cathleen Crudden speaking at the Oct 22 session.

www.acs-catalysis.org/post/input-n...

Thioxanthone Synthesis from Thioureas through Double Aryne Insertion into a Carbon-Sulfur Double Bond Thioxanthone synthesis from o-silylaryl triflates and thioureas is disclosed. Double aryne insertion into the C═S double bond of thioureas and subsequent hydrolysis realized the facile preparation of ...

Wait, we (@S_Yoshida_Lab) made thioxanthones?! Double aryne insertion into thioureas + simple hydrolysis = super functionalized thioxanthones. Who saw that coming? #AryneChemistry #OpenAccess #OrgLett #ChemSky
pubs.acs.org/doi/10.1021/...

Reductive Amination Reactions Using Sodium Hypophosphite: a Guide to Substrates The reactions of reductive amination are of paramount importance as tools of synthetic organic chemistry. Recently, the applicability of sodium hypophosphite as a promising reductant for such reaction...

🆕 Catalyst free reductive amination with non toxic, cheap NaH₂PO₂!♻️

16 amine–carbonyl combos covered, tunable conditions & kinetic insights.

Check out the #JOrgChem guide to substrates📘

👉 doi.org/10.1021/acs....

@ChusovGroup @pubs.acs.org

Call For Papers: Chemistry and Biology of Peptides | ACS Publications Chemistry Blog This Special Issue will celebrate the chemistry and biology of peptides, from synthesis, to structure and modifications, to biology and applications, and finally to degradation. Submit your manuscript...

Do you work at the interface of chemistry and biology in the field of peptides? #JOrgChem and #Biochemistry have put out a Call for Papers related to all things peptides!

Submission deadline: Dec 31, 2025

axial.acs.org/biology-and-...

Some Items of Interest to Process R&D Chemists and Engineers You have not visited any articles yet, Please visit some articles to see contents here.

This month's #OPRD Items of Interest is out!

pubs.acs.org/doi/10.1021/...

Congrats to the organic lectureship award winners!

Hsiao-Wu Hsieh - axial.acs.org/organic-chem...

Rui Shang - axial.acs.org/catalysis/me...

Gabriel Schaefer - axial.acs.org/organic-chem... (lecture by Michael Willis)

Jacquelyne Read - axial.acs.org/organic-chem...

N-Heterocyclic Carbene/Organic Photoredox-Cocatalyzed Acyl Azolation of Alkenes with Acyl Azoles We have developed the N-heterocyclic carbene/organic photoredox-cocatalyzed acyl azolation of styrenes using acyl azoles. The cooperative action of organic photoredox catalysis and NHC catalysis enabl...

Just published in #OrgLett ! We report an NHC/organic photoredox cocatalyzed acyl azolation of styrenes using acyl azoles. Congratulations Kanata and Yamato! doi.org/10.1021/acs....

Check out our latest initiatives to celebrate Chinese researchers publishing in #OrgLett! Learn about our Chinese New Year Covers Series, 2025 Collection of 36 Letters from China, ACS All-Star Academy, and more!

axial.acs.org/organic-chem...

A very big congrats to the #OPRD winners of the Outstanding Publication of the Year Award, co-sponsored by the ACS Division of Organic Chemistry: Dr. Hsiao-Wu Hsieh and colleagues!
axial.acs.org/organic-chem...

A very big congrats to the #JOrgChem winners of the Outstanding Publication of the Year Award, co-sponsored by the ACS Division of Organic Chemistry: Prof. Jacquelyne A. Read and colleagues!

axial.acs.org/organic-chem...

@organicdivision.org

A very big congrats to the #OrgLett winner of the Outstanding Publication of the Year Award, co-sponsored by the ACS Division of Organic Chemistry: Dr. Gabriel Schäfer and colleagues!

axial.acs.org/organic-chem...