Bernhard Zdársky

AKT signaling restrains tumor suppressive functions of FOXO transcription factors and GSK3 kinase in multiple myeloma Key Points. FOXO transcription factors and the GSK3 kinase are pivotal tumor suppressors restrained by AKT activity in MM cells.FOXO and GSK3 destabilize M

This aligns with findings from our lab where we show that AKT inhibition synergizes with MCL-1 inhibition to induce cell death in myeloma cells. ashpublications.org/bloodadvance...

04.05.2025 09:20 — 👍 3    🔁 1    💬 0    📌 0

🔥Interestingly, loss of myeloid STAT3 attenuated steatosis but aggravated inflammation and fibrosis
www.mdpi.com/2073-4409/14...

#Liver #STAT3 #Fibrosis

23.10.2025 04:06 — 👍 0    🔁 0    💬 0    📌 0

sticker, auf dem steht: bist du antiantifa, bist du fa

fanmade sticker🖤🌈

16.10.2025 18:34 — 👍 119    🔁 14    💬 3    📌 0

‼️Our latest study, “Loss of STAT3 in acute myeloid leukemia favors tissue infiltration linked to CXCR4 signaling,” is now out in @bloodneoplasia.bsky.social

#AML #STAT3 #CXCR4 #MLL-AF9
www.sciencedirect.com/science/arti...

15.10.2025 14:53 — 👍 8    🔁 2    💬 0    📌 0

Dietary cysteine enhances intestinal stemness via CD8+ T cell-derived IL-22 - Nature Dietary cysteine enhances intestinal stem cell-mediated intestinal repair following injury by promoting CD8 T cell-regenerative immune responses.

Nature research paper: Dietary cysteine enhances intestinal stemness via CD8+ T cell-derived IL-22

go.nature.com/4gPjgfA

07.10.2025 14:21 — 👍 7    🔁 4    💬 1    📌 0

Genomics fellows - ever wondered what to do with histopathology (e.g. H&E slides)? 🔬➕🧬🟰🤩 I am super excited to have contributed with @evachrenkova.bsky.social to this amazing effort of @andre-rendeiro.com & @yimin-zheng.bsky.social for multimodal data integration: LazySlide!🧵👇

02.06.2025 09:02 — 👍 14    🔁 3    💬 0    📌 0

STAT5 and STAT3 balance shapes dendritic cell function and tumour immunity - Nature Immune checkpoint blockade activates T cell immunity by reprogramming the STAT3 and STAT5 transcriptional pathways in dendritic cells, and STAT3 degradation is effective for treating tumours of multiple cancer types in mouse models.

Nature research paper: STAT5 and STAT3 balance shapes dendritic cell function and tumour immunity

https://go.nature.com/4dhenKu

19.05.2025 09:40 — 👍 10    🔁 1    💬 0    📌 0