John Janetzko

Genetic architecture of the murine red blood cell proteome reveals central role of hemoglobin beta cysteine 93 in maintaining redox balance Keele et al. uncover the genetic architecture of the proteome of fresh and stored red blood cells using a multi-omics analysis of 350 genetically diverse mice. Their work reveals how a hemoglobin redo...

Now out at @cellpress.bsky.social Cell Genomics, we characterized the genetic architecture of the murine red blood cell proteome using omics profiling in 350 genetically diverse mice.
The goal was to understand how genetic variation shapes RBC metabolism, redox homeostasis, and storage outcomes. 1/n

From my perspective, there are many potential problems with this decision.

It is likely to disadvantage applications from early stage investigators and for certain classes of proposals.

More on this later...

2/13

Well said. Tragic loss for sure. Hope you and everyone there at UCSF are hanging in.

Gotta keep the receptor soluble 😂

@cupharmacology.bsky.social @cu-bmg.bsky.social @cuanschutz.bsky.social

Happy Halloween from the Janetzko lab 🎃 👻

I’m crushed. She was such a great human being who stood up for their principles like few others. She will be deeply missed 😢

Whoa I’m sorry did I read this right?! No! 😢 this is so horrible.

👆🏻 yup

The issue of Molecular Pharmacology edited by @nicoleperryhauser.bsky.social and me is finally finished!

As always, it was a joy to work together, and I think we succeeded in compiling some great papers from young GPCR investigators 🤩

Check it out 👇

www.sciencedirect.com/science/arti...

Emerging Voices in GPCR Biology

A new special issue entitled “Emerging Voices in GPCR Biology” is now available in Molecular Pharmacology, highlighting innovative research led by early-career investigators (ECIs) across key areas of G protein-coupled receptor (GPCR) science.

www.sciencedirect.com/science/arti...

Thanking the reviewers

A lab that collects data together stays together. Feeling like the luckiest PI to work with such great folks 🤩🔬 @cuanschutz.bsky.social @cu-bmg.bsky.social

Welcome New Members graphic. Nicole Kaiser, PharmD, Vicki Catenacci, MD, Mohammad Bilal, MD, John Janetzko, PhD, Wyatt Shields, PhD, Christine Conageski, MD, Ally Nguyen, PhD, Matthew Witkowski, PhD, Peter Fecci, MD, PhD, Stephanie McGrath, DVM, Glen Peterson, DNP, Brenna McGinn, PhD, MSM.

We have new members! Welcome to the CU Cancer Center! 👏

The acknowledgements section speaks to considerable privilege. Without a senior author, he and his classmate were provided with lab space, purified protein, and technical help. Their paper was communicated to PNAS. I doubt many undergraduate researchers have received comparable support.

31/n

So you’re saying there’s a chance

Tbf lottery still has to be lower chance, but point is very well taken

With news that NIH grant success rates are now below 5%, consider the effort that goes into one of these grants (apart from you, who submitted 60 AI-written grants)- why would you put in that much effort knowing your chances are only slightly better than winning a lottery? 1/

No better time to call or email your members of Congress. Next year’s NIH budget is being debated in the Senate. A new nonpartisan campaign is making it easy to defend science and protect America’s innovation. Just follow this link to contact your representatives: www.protectscienceandinnovation.org

We are going to hear a lot in the near future about how University brass “has to make hard decisions”. Twill be interesting to see who those hard decisions land upon.

Summary Table of the massive defunding of biomedical research in the United States
www.nytimes.com/interactive/...

a cartoon says hey everybody an old man 's talking while bart simpson looks on ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on

A short Bluetorial about my early days as the Director of the National Institute of General Medical Sciences (NIGMS) at NIH.

The importance of feeling responsibility and taking pride in doing the best job you can

Oh no. This is insanity! Hopefully if we do twist the pretzel in 2026 it gets untwisted again in 2028.

Systematic identification and characterization of eukaryotic and viral 2A peptide-bond-skipping sequences Rao et al. identified thousands of previously unknown 2A peptides across both viruses and eukaryotes using an HMMER analysis. The authors further identified a unique class of 2A peptides, class B, who...

Excited to see this collaborative work with Olivia Rissland's lab finally out. We found lots of 2A peptides and an entirely new 2A class.

www.cell.com/cell-reports...

The world is in chaos, but we still need to rally with our people!

Janetzko-Bell lab and friends happy hour to celebrate grant submissions, new additions and scientific accomplishments 🎉

@cu-bmg.bsky.social

In America, we have no kings.

🥴

Membrane phosphoinositides allosterically tune β-arrestin dynamics to facilitate GPCR core engagement Arrestin proteins bind active G protein-coupled receptors (GPCRs) through coordinated protein-protein, protein-phosphate, and protein-lipid interactions to attenuate G protein signaling and promote GP...

Setting up a lab has been no joke. Today, I'm stoked to have one more piece of my postdoc work out in the wild.
Several more manuscripts to go, and I don't have a lot of time for a blue-torial(?) today, but enjoy and happy to get any feedback on this story.

www.biorxiv.org/content/10.1...

Sometimes this job can feel like a lot. But sometimes it’s the best job you could imagine. Your whole lab tells you they want to come in on Saturday to finish an experiment we’ve worked up to and you get to see the look of amazement on your tech’s face when her first negative stain works 😍

Fml