Kellianne

Congratulations to Dr. Zach Augur, who successfully defended his PhD thesis on Friday!! Zach had an amazing defense which highlighted his incredible productivity in the lab, culminating in 3 first-author publications throughout his thesis work!

Our study “Genetic and proteomic analysis identifies BAG3 as an amyloid‑responsive regulator of neuronal proteostasis" was published in Acta Neuropathologica this week! Congratulations to lead author Zach Augur, who will be defending his thesis later this week!!
link.springer.com/epdf/10.1007...

Optineurin deficiency disrupts phosphorylated tau proteostasis and clusterin expression in human neurons - Acta Neuropathologica Communications Optineurin (OPTN) is an autophagy adaptor protein involved in selective autophagy, including aggrephagy and mitophagy. Pathogenic mutations in OPTN have also been linked to amyotrophic lateral scleros...

New TYP lab publication from co-authors
Zach Augur and @garrettfogo.bsky.social
on deciphering the function of Optineurin in iPSC-derived Neurons and Astrocytes! This will be the first of 3 first-author publications from Zach's PhD thesis! link.springer.com/article/10.1...

Huge congrats to @zacharyrmurphy.bsky.social selected as a 2025 Fujifilm Fellow at @harvard.edu 🎉

The Fujifilm Fellowship Program fully funds PhD students doing groundbreaking work in the life sciences!!

Astrocyte induction of disease-associated microglia is suppressed by acute exposure to fAD neurons in human iPSC triple cultures Lish et al. present a co-culture system of iPSC-derived human microglia, astrocytes, and neurons to investigate intercellular communication across different environmental and genetic contexts. Transcr...

New TYP lab publication led by PhD student @alexlish.bsky.social out today in @cp-cellreports.bsky.social! We present a reproducible neuron-astrocyte-microglia tri-culture model to better reproduce intercellular interactions in Alzheimer's disease. Read more here: www.cell.com/cell-reports...

Huge congrats to our Master’s student Emma Karp for receiving the GBM Master Prize from the Society for Biochemistry and Molecular Biology! 🏆🧬
Emma earned it for her work in Biomedical Neurosciences at TUM! 🎓🧠
🔗 gbm-online.de/de/studium-k...

We are proud to celebrate Tracy as the recipient of the Harvard Medical School Clifford Barger Excellence in Mentoring Award! 🎉 Her guidance, encouragement, and dedication mean so much to all of us. Congratulations on this well-deserved honor!

Excited to be back @umasschan.bsky.social for the Boston interactive glial group meeting! So many great talks!

CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density Lish et al. reveal that AD-protective CLU alleles enhance CLU upregulation in response to accumulated neuropathology, thereby dampening inflammatory signaling between microglia and astrocytes. Using s...

New TYP lab paper out today in @cp-neuron.bsky.social led by PhD student @alexlish.bsky.social! We took a deep dive into the mechanisms underlying CLU in AD using innovative iPSC, mouse, and human data approaches. Be sure to give it a read!
www.cell.com/neuron/abstr...

Congratulations our newly-minted PhD candidate Olivia Pembridge on passing her PQE with flying colors today! Olivia will be using a wide array of iPSC and organoid models to study mechanisms of neurodevelopment!

Truly grateful for the opportunity to share my work at the CSHL Brain Barriers meeting! It’s been amazing to hear about all the exciting and innovative research happening across the community 🧠🚪🩸 #cshlbbb

Congratulations to TYP lab Postdoctoral Research Fellow @heuerwego.bsky.social on being awarded a @brightfocus.bsky.social Alzheimer's Disease Research Fellowship! Sarah is using iPSCs to determine the cellular impacts of ABCA7 mutations in Alzheimer's disease!

Proud of our amazing postdoc @kelliannealexa1.bsky.social who gave a fantastic talk today on her work with neuronal hyperexcitability and modeling blood-brain-barrier dysfunction in Alzheimer's disease today as part of the BWH Neuroscience Seminar Series!

Congrats @alexlish.bsky.social! You should be super proud of the work you’ve accomplished! Can’t wait to see what you do next!

Congrats @zacharyrmurphy.bsky.social!!!

Contributions of Genetic Variation in Astrocytes to Cell and Molecular Mechanisms of Risk and Resilience to Late‐Onset Alzheimer's Disease Generation and characterization of induced pluripotent stem cell (iPSC)-derived astrocytes from 44 aged humans reveals congruence of gene expression profiles between astrocyte cultures and brain and ...

New TYP lab publication out today in Glia, led by talented previous PhD student Hyo Lee! Our first big analysis of induced Astrocytes from 44 individuals in the ROSMAP cohort.
You can find it here: onlinelibrary.wiley.com/doi/10.1002/...

Happy #FluorescenceFriday and inaugural bluesky post- some beautiful microglia-neuron-astrocyte co-cultures from TYP lab postdoc @heuerwego.bsky.social!

The elf has arrived at the TYP lab in style—complete with a sleigh and hippo-reindeer! 🎅🛷 #ElfInTheLab #LabLife #ElvesBehavingBadly

Back in Houston pt. 2!! This time, I had the pleasure to present a poster on Ultra-Rapid ddPCR with my co-first author Emilia Bianchini at SNO 2024. A very fun weekend! #ddPCR #SNO2024

🎨 In case anyone need…

The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!

Check it out 👇
bioart.niaid.nih.gov

Tenure-track Faculty position in Cell and Developmental Biology - Atlanta, Georgia job with Emory University | 664684 This search is open to investigators conducting mechanistic studies of developmental cell biology using genetically tractable model organisms.

Now that half of SciTwitter is here…

Come be my colleague!

The Dept of Cell Biology @EmoryUniversity is recruiting a developmental cell biologist.

🔬Do you study mechanisms of development using cell biological (and other) approaches? Join us!🔬

TY for RT!

jobs.sciencecareers.org/job/664684/t...

scientific illustration

📔 New review in Neuropharmacology, "Strategies to dissect microglia-synaptic interactions during aging and in #Alzheimer's disease" by Sarah Heuer, Erik Bloss & Gareth Howell:

🧪🤝🖥️ 🧬 ⑂ #jaxresearch #ScientificResearchPublishing
#alzsky #Neuroscience

doi.org/10.1016/j.ne...

Sharp as a tack or vague and forgetful? Erik Bloss, Gareth Howell and predoctoral associate Sarah Heuer are examining the effects of aging in mouse neurons and synapses.

What happens in our brains to bring about such decline and why does it vary so much between individuals? JAX's Erik Bloss, Gareth Howell & Sarah Heuer examined the effects of aging in mouse neurons & synapses, with findings in a new Aging Cell paper #Neuroscience 🧪🤝🖥️ 🧬:

www.jax.org/news-and-ins...

PhD student: "please don't be excited yet, these are just preliminary results, I still need to repeat the experiment multiple times"
PI:

Fluorescence Friday! Ipsc derived endothelial cells (green/ red- tight junction proteins, blue-nucleus) #Bloodbrainbarrier #ipsc #stem #neuroscience