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Neuron

@cp-neuron.bsky.social

Neuron publishes ground-breaking research papers, reviews & commentary across neuroscience and is a premier intellectual forum for the neuroscience community. https://www.cell.com/neuron/home

1,209 Followers  |  27 Following  |  279 Posts  |  Joined: 19.12.2024  |  1.9602

Latest posts by cp-neuron.bsky.social on Bluesky

Semaphorin–Neuropilin Interactions Underlying Sympathetic Axon Responses to Class III Semaphorins (Neuron 21, 1283–1290; December, 1998)
10.12.2025 16:24 — 👍 1    🔁 0    💬 0    📌 0
Sympathetic functional units encoded by genetically defined postganglionic neurons Wei et al. found two CG-SMG sympathetic subpopulations: Calb2-positive neurons project to gut muscle, forming endings at myenteric ganglia to regulate motility, and Nxph4-positive neurons innervate organ blood vessels, forming perivascular endings that act as visceral vasoconstrictors controlling blood flow.
10.12.2025 13:35 — 👍 0    🔁 0    💬 0    📌 0
Modulation of metastable ensemble dynamics explains the inverted-U relationship between tone discriminability and arousal in auditory cortex Papadopoulos et al. report an inverted-U relationship between tone discriminability and arousal in mouse auditory cortex. A spiking network model with clustered connectivity explains the effects via modulations of metastable attractor dynamics. The model suggests that transitions in dynamical regimes mediate state-dependent sensory processing and induce changes in neural variability.
09.12.2025 16:23 — 👍 0    🔁 0    💬 0    📌 0
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The hologenome in brain health and disease The perspective by Dooling and Costa-Mattioli highlights how the hologenome, the collective genomes of the host and associated microbes and their interactions, modulates brain health and recommends a roadmap for studying the hologenome in complex behaviors.
05.12.2025 16:24 — 👍 0    🔁 1    💬 0    📌 0
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New issue: www.cell.com/neuron/current

The cover highlights a Review article from 24 co-authors that discusses the principles of brain clearance, including the role of CSF influx, sleep-dependent waste removal, and connections to the immune system. Art by Nadia Alzoubi.

03.12.2025 20:30 — 👍 12    🔁 0    💬 0    📌 0
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Protective ApoE variants support neuronal function by effluxing oxidized phospholipids Ralhan et al. show that ApoE2 and ApoE3 Christchurch on lipid particles efflux oxidized phospholipids from neurons via the ABCA7 transporter. This reduces the burden of oxidized lipids, which improves lysosomal function and protects neurons from ferroptosis.
02.12.2025 16:24 — 👍 6    🔁 3    💬 0    📌 0
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Biased histamine signaling selectively gates fat preference Zheng et al. uncover the neural basis for specific food preferences, showing that separate thalamic populations mediate intake of high-fat and high-sugar diets. They identify a histamine H3 receptor-mediated circuit that specifically regulates fat consumption in response to orosensory cues, suggesting potential targets for precise weight management.
26.11.2025 19:36 — 👍 1    🔁 0    💬 0    📌 0
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Exploiting correlations across trials and behavioral sessions to improve neural decoding Animals share common patterns of brain activity across trials and sessions. Exploiting this shared structure improves the prediction of behavior from neural activity, scales across many sessions and brain regions, and offers interpretable alternatives to deep-learning-based foundation models.
26.11.2025 16:23 — 👍 3    🔁 0    💬 0    📌 0
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Distinct roles of prefrontal subregion feedback to the primary visual cortex across behavioral states Ährlund-Richter et al. show that in mice, discrete subregions of the prefrontal cortex send distinct feedback signals to the primary visual cortex. These pathways differentially modulate visual processing depending on behavioral state, revealing how higher-order cortical areas dynamically influence sensory representations to integrate perception with internal state.
25.11.2025 16:24 — 👍 4    🔁 0    💬 0    📌 1
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Resolving the mysteries of brain clearance and immune surveillance This review by Kipnis et al. explores recent advances in brain fluid dynamics, emphasizing CSF flow’s role in waste clearance, the glymphatic and meningeal lymphatic systems, and neuroimmune interactions, with implications for neurodegenerative and neuroimmune disorders.
24.11.2025 19:37 — 👍 4    🔁 2    💬 0    📌 0
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Ultrastructural membrane dynamics of mouse and human cortical synapses Eddings et al. illustrate that synaptic membrane trafficking can be studied with millisecond resolution in resected human brain tissues using the technique “zap-and-freeze” time-resolved electron microscopy. Using this method, they find that synaptic vesicles are recycled via ultrafast endocytosis in human neocortical slices.
24.11.2025 16:24 — 👍 4    🔁 1    💬 0    📌 0
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A transcriptomic atlas of astrocyte heterogeneity across space and time in mouse and marmoset In this NeuroResource, Schroeder et al. present a transcriptomic atlas across brain regions and developmental time points in mouse and marmoset. Detailed analysis focused on astrocytes revealed that their embryonically patterned regional heterogeneity changes significantly over the course of postnatal development, with both species conservation and divergence.
20.11.2025 16:23 — 👍 3    🔁 0    💬 0    📌 0
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Cortical PV interneurons regulate loudness perception and sustainably reverse loudness hypersensitivity Noise damages the cochlea, triggering maladaptive plasticity in the auditory cortex (ACtx) that makes moderate-intensity sounds seem uncomfortably loud. Clayton, Awwad, McGill, et al. show that brief activation of parvalbumin-expressing inhibitory neurons in the ACtx at 40 Hz sustainably reverses this plasticity and restores normal loudness perception for up to 1 week.
19.11.2025 16:23 — 👍 2    🔁 0    💬 0    📌 0
The neuroscience of brain cancers

The neuroscience of brain cancers

"The neuroscience of brain cancers"
http://dlvr.it/TPKl38

@michelle_monje.bsky
@cp-neuron.bsky.social
#SfN2025

18.11.2025 12:46 — 👍 4    🔁 2    💬 0    📌 0
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New issue is out: www.cell.com/neuron/current
The cover by Heng Zhao features a NeuroResource on a new ultrabright chemical labeling technique for rapid neural connectivity profiling, from single neurons to whole-body circuits in mice.
Paper by Zhong et al: www.cell.com/neuron/fullt...

19.11.2025 16:14 — 👍 3    🔁 0    💬 0    📌 0
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C5aR1+ microglia exacerbate neuroinflammation and cerebral edema in acute brain injury Zhou et al. identify a pro-inflammatory C5aR1⁺ microglial subtype enriched in human cerebral edema tissues after TBI and ICH. C5aR1⁺ microglia amplify neuroinflammation, promote neurotoxic astrocyte polarization via LGALS9-CD44, and recruit neutrophils via CCL3/CCL5. Pharmacological C5aR1 inhibition reduces cerebral edema, highlighting a potential therapeutic target.
18.11.2025 16:24 — 👍 0    🔁 0    💬 0    📌 0
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The orbitofrontal cortex updates beliefs for state inference Schiereck et al. find that expert rats update subjective beliefs to infer hidden task states, a process they show is impaired by inactivation of OFC. Rats naive to hidden states passively adapt to reward statistics. Neural activity in OFC reflected the use of distinct strategies, identifying neural correlates of inference.
17.11.2025 19:36 — 👍 1    🔁 0    💬 0    📌 0
Towards a functional future for the cognitive neuroscience of human aging

Towards a functional future for the cognitive neuroscience of human aging

"Toward a functional future for the cognitive neuroscience of human aging"
http://dlvr.it/TPJBg7

Douglas D. Garrett, @zoyamooraj.bsky.social & colleagues
@cp-neuron.bsky.social
#SfN2025

16.11.2025 21:16 — 👍 2    🔁 1    💬 0    📌 0
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Integrative analysis of single-neuron projectomes links connectome, transcriptome, and function in the mouse cortex Gao et al. reported a comprehensive single-neuron projectome for 18,621 neurons covering the entire mouse cortex, revealing fine-grained organizations of cortico-cortical connectivity and cortico-subcortical projections. Integrative analysis showed a high degree of correlation between cortico-cortical connectivity with calcium activity, gene expression, and electrophysiology.
17.11.2025 16:23 — 👍 3    🔁 0    💬 0    📌 0
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Polarized Signaling Endosomes Coordinate BDNF-Induced Chemotaxis of Cerebellar Precursors (Neuron 55, 53–68; July 5, 2007)
15.11.2025 16:24 — 👍 0    🔁 0    💬 0    📌 0
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Hypertension-induced neurovascular and cognitive dysfunction at single-cell resolution Hypertension is a major cause of cognitive decline, but the underlying mechanisms are unclear. Using scRNA-seq in an angiotensin II mouse model, Schaeffer and Pacholko identify early endothelial, interneuron, and oligodendrocyte vulnerability linked to angiotensin II signaling, revealing molecular pathways that drive later neurovascular dysfunction and cognitive impairment in hypertension.
14.11.2025 16:23 — 👍 3    🔁 0    💬 0    📌 0
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Conceptual and methodological flaws undermine claims of a link between the gut microbiome and autism Claims that the gut microbiome causally contributes to autism regularly appear in the scientific literature and popular press. Mitchell et al. critically examine influential studies underpinning these claims and find them conceptually and methodologically flawed.
13.11.2025 16:24 — 👍 0    🔁 0    💬 0    📌 0
What we can learn from the first personalized CRISPR-treated baby to tackle genetic brain disorders The landmark report on personalized CRISPR genome editing to treat an infant (baby KJ) with a life-threatening liver disease sparked widespread attention, ushering in a new era of precision genetic intervention. This piece discusses the key challenges and opportunities in translating this milestone into treatments for genetic brain disorders.
12.11.2025 19:37 — 👍 0    🔁 0    💬 0    📌 0
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Globally patterned locus coeruleus-norepinephrine neuron-pericyte coupling orchestrates brain-wide vascular dynamics Through whole-brain neurovascular imaging in larval zebrafish, Sun and Peng et al. show that the locus coeruleus-norepinephrine (LC-NE) system orchestrates globally patterned pericyte activities through complementary direct NE and indirect glia-relayed actions. Such LC-NE neuron-pericyte coupling exerts global vasoconstrictive drives that coordinate blood flow and support sustained behavioral performance.
12.11.2025 16:23 — 👍 2    🔁 0    💬 0    📌 0
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Structure in noise: Recurrent connectivity shapes neural variability to balance perceptual and cognitive demands in the human brain Does neural variability reflect random noise or a feature that benefits adaptive behavior? Using intracranial recordings in humans, Terlau et al. demonstrate that neural variability results from the r...

New work from the lab published in @cp-neuron.bsky.social by @jonasterlau.bsky.social and Jan Martini. We describe that trial-by-trial variability indexes recurrent connectivity across the cortical hierarchy, which supports reliable and flexible coding www.cell.com/neuron/abstr... (1/4)

10.11.2025 17:06 — 👍 63    🔁 23    💬 2    📌 0
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Structure in noise: Recurrent connectivity shapes neural variability to balance perceptual and cognitive demands in the human brain Does neural variability reflect random noise or a feature that benefits adaptive behavior? Using intracranial recordings in humans, Terlau et al. demonstrate that neural variability results from the recurrent connectivity structure along the cortical hierarchy, which supports the spatiotemporal unfolding from perceptual to cognitive processing.
08.11.2025 00:09 — 👍 8    🔁 4    💬 0    📌 0
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Human cortical dynamics of auditory word form encoding Zhang, Leonard, et al. use high-density direct human brain recordings to reveal how the superior temporal gyrus (STG) detects word boundaries in natural speech and encodes whole auditory word forms. Neural populations dynamically reflect properties of the whole-word units listeners perceive in continuous, connected speech.
07.11.2025 19:36 — 👍 2    🔁 0    💬 0    📌 0
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Check out our latest issue: www.cell.com/neuron/current

The cover by Avesta Rastan illustrates work from Marino et al. showing how postural and goal signals are flexibly combined in the motor cortex to generate movements. Read the paper here: www.cell.com/neuron/fullt...

07.11.2025 16:43 — 👍 2    🔁 0    💬 0    📌 0
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Social interaction in mice suppresses breast cancer progression via a corticoamygdala neural circuit Wen et al. reveal that social interaction reduces breast cancer progression by activating ACCGlu→BLAGlu circuits, inhibiting intratumoral sympathetic activity. This neural mechanism enhances antitumor...

🧠 Article intéressant publié dans @cp-neuron.bsky.social.
🐁 Les souris atteintes de cancer du sein résistent mieux grâce aux interactions sociales.
🤗 Ne négligeons pas l'aspect social dans l'accompagnement des patientes avec un cancer.
#octobrerose #culturescience
www.cell.com/neuron/fullt...

24.10.2025 09:18 — 👍 3    🔁 2    💬 0    📌 0

🧠 Thrilled to share our NeuroView with Ellie Pavlick!

"From Prediction to Understanding: Will AI Foundation Models Transform Brain Science?"

AI foundation models are coming to neuroscience—if scaling laws hold, predictive power will be unprecedented.

But is that enough?

Thread 🧵👇

24.10.2025 11:22 — 👍 22    🔁 8    💬 2    📌 0

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