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@cp-neuron.bsky.social

Neuron publishes ground-breaking research papers, reviews & commentary across neuroscience and is a premier intellectual forum for the neuroscience community. https://www.cell.com/neuron/home

1,110 Followers  |  26 Following  |  229 Posts  |  Joined: 19.12.2024  |  1.6317

Latest posts by cp-neuron.bsky.social on Bluesky

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Restoration of temporal separability between beta and movement ensemble co-firing with motor recovery Choi et al. demonstrate that stroke disrupts temporal separability between beta and movement-related ensemble co-firing states, which is restored during recovery. They also show that low-frequency alternating current stimulation enhances separability, improves motor performance, and thus represents a promising therapeutic approach.
08.10.2025 18:37 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Synaptic priming: A framework for pharmacotherapy in depression Through the perspective of metaplasticity, Brown et al. examine the therapeutic effects of intermittent ketamine administration and explore how targeting spatiotemporal features of antidepressant dosing and environmental conditions may improve the effectiveness of treatments for depression.
08.10.2025 15:23 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Neuromorphic is dead. Long live neuromorphic In this NeuroView, Giacomo Indiveri discusses the origins and evolution of neuromorphic engineering, reflects on recent shifts toward digital and AI-centric approaches, and advocates for a revival of the field’s original principles, emphasizing analog, brain-inspired systems and the importance of fundamental neuroscience for future progress.
03.10.2025 23:09 β€” πŸ‘ 7    πŸ” 2    πŸ’¬ 0    πŸ“Œ 1
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Identification of the peptide Vulnusin, a wound signal that mediates mechanical-injury-induced nociception in Drosophila Guo et al. identify the peptide Vulnusin as an acute wound signal that activates C4da nociceptors through the PPK1/PPK26 ion channel in Drosophila larvae. Vulnusin localizes in the extracellular space apical to the epidermis when uninjured but reaches the C4da nociceptor upon damage to trigger the nociceptive rolling behavior.
03.10.2025 18:37 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Segregated supramammillary-dentate gyrus circuits modulate cognitive and affective function in healthy and Alzheimer’s disease model mice Luo et al. identify distinct supramammillary-dentate gyrus subcircuits that differentially regulate memory and emotion. In Alzheimer’s disease (AD) models, these pathways show aberrant activity, but targeted optogenetic activation selectively restores cognitive or affective functions, revealing circuit-level mechanisms underlying diverse AD symptoms and highlighting potential therapeutic targets.
03.10.2025 15:24 β€” πŸ‘ 3    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
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Hippocampal ripple diversity organizes neuronal reactivation dynamics in the offline brain Castelli et al. identify two ripple profiles in hippocampal CA1. Radsink ripples integrate superficial- and deep-sublayer pyramidal cells into dense, higher-dimensional coactivity motifs that stably reactivate recent waking experience during sleep. LMsink ripples primarily recruit deep-sublayer cells into sparse, lower-dimensional motifs that gradually drift from reactivating prior toward recent representations.
03.10.2025 12:36 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Hunger modulates exploration through suppression of dopamine signaling in the tail of the striatum Kamath et al. examine the neural mechanism by which hunger makes animals take more risks. They show that hunger neurons in the hypothalamus suppress threat and salience-related dopamine signals in the tail of the striatum during bouts of novelty exploration and risk assessment.
02.10.2025 23:08 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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SCOPE-C reveals long-range enhancer networks emerging as key regulators during human cortical neurogenesis Jia et al. develop SCOPE-C, a method to map open chromatin and associated chromatin loops from low-input samples. Applying it to the fetal cortex of humans, macaques, and mice, they show that human excitatory neurons form extended enhancer-promoter networks, enriched with human-biased enhancers and neurodevelopmental disorder SNPs, compared with those of other species.
02.10.2025 18:36 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Astrocyte-mediated central amygdala microcircuit gates comorbid anxiety symptoms in chronic pain Zan et al. have identified a neuroglial microcircuit within the central amygdala modulating anxiety symptoms comorbid with chronic pain through astrocytes. They find that pain induces dynorphin release by activating the CeLPdyn-CeM microcircuit. Dynorphin activates astrocytes by acting on kappa receptors to increase CeM neuron excitability by releasing gliotransmitter.
02.10.2025 15:24 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Ultra-high-density Neuropixels probes improve detection and identification in neuronal recordings Ye, Shelton, et al. describe a silicon probe with ultra-high site density for recording neural activity in the brain. Higher site density improves the quality and yield of detected neurons. These probes robustly detect extracellular fields with small spatial extents, including axons, across species and brain regions. In addition, these probes improve classification of neuronal cell types.
30.09.2025 15:23 β€” πŸ‘ 4    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Treg-microglia partnership in the injured spinal cord preserves Treg cell function and regulates microglial cholesterol metabolism Qin et al. reveal the spatiotemporal dynamics, clonality, and transcriptomic characteristics of SCI-associated Treg cells, identifying their crucial role in SCI functional recovery. Mechanistically, microglia act as essential MHC II antigen-presenting cells that sustain neuroprotective Treg cells, which in turn modulate microglial inflammation and cholesterol metabolism via CTLA-4 and Abcg1 upregulation.
29.09.2025 15:23 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Entangled cellular and molecular relationships at the sensory neuron-cancer interface (Neuron 113, 2760–2790; September 3, 2025)
27.09.2025 15:23 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Within-individual precision mapping of brain networks exclusively using task data Du et al. demonstrate that task data alone can map the detailed organization of within-individual brain networks. Applications include reanalysis of existing data, pooling of task and resting-state data to increase statistical power, and studies that solely acquire task data to simultaneously estimate brain networks and extract the evoked response.
26.09.2025 15:23 β€” πŸ‘ 1    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Dysfunction of cortical GABAergic projection neurons as a major hallmark in a model of neuropsychiatric syndrome Using advanced transcriptomic and physiological profiling, the authors identified deep-layer long-range GABAergic projection neurons as the most disrupted neuronal subtype and key contributor to brain dysfunction in the 15q13.3 neuropsychiatric mouse model. Late-onset impairments in these neurons disrupted sleep, which was rescued by chemogenetic inhibition, offering mechanistic insight and therapeutic potential.
24.09.2025 15:23 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Gut-induced alpha-Synuclein and Tau propagation initiate Parkinson’s and Alzheimer’s disease co-pathology and behavior impairments (Neuron 112, 3585–3601.e1–e5; November 6, 2024)
23.09.2025 15:23 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Reproducible Brain Charts: An open data resource for mapping brain development and its associations with mental health Shafiei et al. introduce Reproducible Brain Charts (RBC), an open, reproducible developmental neuroimaging resource combining data from five large cohorts of youth. They provide harmonized psychiatric phenotypes, curated raw data, and uniformly processed derived imaging data. All data and processing pipelines are openly shared without a data use agreement.
22.09.2025 15:23 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Neural mechanisms underlying the recovery of voluntary control of motoneurons after paralysis with spinal cord stimulation Spinal cord stimulation (SCS) restores voluntary motor control after paralysis, but this experimental observation remains unexplained. In this study, Balaguer et al. show that residual brain inputs transform subthreshold, SCS-mediated excitatory postsynaptic potentials into action potentials, producing SCS-entrained motoneuron firing. The brain can regulate this entrainment, thereby mimicking volitional firing rate control.
19.09.2025 15:23 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Ultrabright chemical labeling enables rapid neural connectivity profiling in large tissue samples Mapping mammalian neural circuits is limited by inefficient labeling and signal loss with depth. Zhong et al. develop LINCS, a chemical labeling toolkit for rapid, ultrabright neural visualization. This accessible pipeline provides robust and uniform connectivity analysis, from single neurons in cleared brains to circuits spanning the entire mouse body.
18.09.2025 18:37 β€” πŸ‘ 5    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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On astrocyte-neuron interactions: Broad insights from the striatum In this review, Khakh discusses the mechanisms, physiology, and pathophysiological relevance of astrocyte-neuron interactions across biological scales from molecules to whole organisms. By highlighting findings from the striatum, Khakh identifies insights of significance to other brain areas and summarizes key open questions and challenges.
18.09.2025 15:23 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Identification of a neural basis for energy expenditure in the mouse arcuate hypothalamus Wang et al. demonstrate that hypothalamic GABAergic Crabp1 neurons promote energy expenditure by targeting multiple nuclei in mice. These neurons are activated by cold and exercise but suppressed by long photoperiod, linking environmental and physiological cues to metabolic homeostasis and offering a potential target for obesity intervention.
17.09.2025 23:08 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Variation in moment-to-moment brain state engagement follows a consistent trajectory during development Ye et al. demonstrate a consistent developmental trajectory for variability in recurring brain state engagement (SEV) across four independent datasets (N > 3,000). SEV increases with age before plateauing in adolescence, with female participants reaching stabilization before male participants. SEV further predicts executive function (EF) in previously unseen individuals.
17.09.2025 18:36 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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The role of mesolimbic circuitry in aversive signaling and opioid dependence This review examines how chronic opioid use reshapes medial ventral tegmental area circuits, increasing sensitivity to aversive stimuli, amplifying negative affect, and reinforcing withdrawal-avoidance behaviors that drive opioid misuse. It also explores how chronic pain may exacerbate these effects through heightened aversive signaling, further increasing misuse risk.
17.09.2025 15:24 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
The how and why of sleep: Motor theory and catecholamine hypothesis This perspective examines sleep’s mechanism (β€œhow”) and function (β€œwhy”). The motor theory posits that sleep is governed by distributed motor-control circuits; the catecholamine hypothesis identifies catecholamine inactivation as the unifying process underlying sleep’s restorative effects on metabolism, immunity, and cognition.
16.09.2025 15:23 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Corticotropin-releasing hormone signaling from piriform cortex to amygdala mediates social homophily in opioid addiction Huo et al. report that opioid-withdrawn mice prefer socializing with opioid-experienced peers, driven by heightened social motivation and mediated by a specific brain circuit, APIRCRH-BMA, activated by peer odor. This social homophily promotes relapse by strengthening addiction-related memories. Social support from non-addicted peers or blocking this pathway aids recovery.
13.09.2025 12:35 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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A rare genetic variant confers resistance to neurodegeneration across multiple neurological disorders by augmenting selective autophagy In Croce et al. the discovery of a rare SNP in the Venezuelan HD kindreds that is associated with a delayed age of onset of up to 23 years reveals how preventing aberrant protein accumulation is protective not only against polyglutamine toxicity but also against Ξ±-synuclein- and tau-mediated toxicity.
12.09.2025 15:23 β€” πŸ‘ 0    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Targeting glucose-inhibited hippocampal CCK interneurons prevents cognitive impairment in diet-induced obesity Landry et al. show that short-term high-fat diet reduces hippocampal glucose availability, driving CCK-IN hyperactivity and memory deficits. Normalizing aberrant PKM2 or CCK-IN activity subsequently protects againstobesity-related cognitive impairments. This study reveals a metabolic-neuronal mechanism linking diet to cognition and highlights potential targets for preventing diet-associated cognitive decline.
11.09.2025 18:37 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Absolute measurement of fast and slow neuronal signals with fluorescence lifetime photometry at high temporal resolution Fluorescence lifetime photometry at high temporal resolution (FLIPR) reports absolute fast and slow neuronal signals across time, brain regions, animals, and behavioral contexts. FLIPR, combined with the new dopamine sensor dLight3.8, allows for the simultaneous measurement of fast and slow changes in dopamine in freely moving mice.
11.09.2025 15:27 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Development of coherent cortical responses reflects increased discriminability of feedforward inputs and their alignment with recurrent circuits Using electrophysiology, calcium imaging, and modeling, Lempel et al. study the development of feedforward-recurrent interactions that underlie reliable cortical representations. They show that visual cortical responses develop interlaminar temporal coherence along with reliability following eye opening, changes driven by improved discriminability of feedforward inputs and their alignment with recurrent circuits.
10.09.2025 18:36 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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#CSNeuroimmune25 starts on a high note with our first keynote @nobelprize.bsky.social laureate David Julius and a packed house in the amazing New York Academy of Medicine.
@cp-immunity.bsky.social @cp-neuron.bsky.social

09.09.2025 14:10 β€” πŸ‘ 5    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Alterations in a cross-hemispheric circuit associates with novelty discrimination deficits in mouse models of neurodegeneration (Neuron 110, 3091–3105.e1–e9; October 5, 2022)
10.09.2025 15:23 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

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