Teresa Rayon

Do you want to pursue your ideas in computational biology independently, running your group in @embl.org‘s uniquely collaborative environment, beside world’s most comprehensive biomolecular data resources @ebi.embl.org in Genome Campus next to @sangerinstitute.bsky.social?
Apply to join us & share 🙏

Cada día de febrero y hasta el día 11, día de la mujer y la niña en la ciencia, la Unidad de Cultura Científica del CIBER publica un nuevo vídeo desmontando mitos de mujeres científicas.

Puedes ir viendo los vídeos en 👉🏻 www.instagram.com/s/aGlnaGxpZ2...

Congrats to you two!! Let’s stay forever young…

The lab turns 4 ⌛️🐭⏳👤

Science happened…

More productive & fun than ever.

Huge thanks to the amazing lab members who make it all possible!!

(Light-sheet microscope movie by Berta Cava Cami)

The ribosome synchronizes folding and assembly to promote oligomeric protein biogenesis Large oligomeric proteins constitute a major fraction of proteomes, but are difficult to refold in vitro, raising the question of how cells direct their biogenesis. Roeselová and Shivakumaraswamy et a...

Our latest cotranslational folding story is now published @cp-molcell.bsky.social. Really cool (I think) new ideas about how exactly the ribosome directs folding and assembly to make sure complicated proteins mature efficiently in cells.
www.cell.com/molecular-ce...

Congrats!! To many many more 🥂

Looking forward to this meeting.
Early bird registration encouraged!!

Spanish EvoDevo at its best. Congrats to the team on this cool work 🥂🍾

Turns out that “deep conservation of CREs across hundreds of millions of years is far more widespread than previously recognized”

Check it out👇🏻👇🏻👇🏻

I think the latest cover helps to remind us that Development is not just a faceless brand of a journal eager to line shareholder pockets - it's a group of people who share a love for #devbio and, in my experience, really are trying to do their best for their community.

#not-for-profit

A human embryo implantation model from the @Rugg-Gunn Lab

*key for understanding the early extraembryonic-maternal interactions

Congrats to everyone involved! It’s been great to see this project develop. Huge credit to the @babrahaminst.bsky.social authors 🥂🍾

www.cell.com/cell/fulltex...

A substantial proportion of people with archaic TKTL1 had college/university degrees, arguing against big impacts on cognition. The results show that the sometimes dramatic effects seen in lab-based experiments on evolutionary variants may not be a guide to real-world impacts in living humans. 11/n

Amazing!!!! Well deserved, congrats 🎉
I’m a big fan of your work 🤓

It's always special when you find your own paper in the table of contents of the journal 😍

"The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube" -> Now out in its final form

www.cell.com/developmenta...

Thinking @ A. Garcia Bellido (1936-2025). Wonderful interview ijdb.ehu.eus/article/0723...
With much of the Scientist and the history of deep thinking in Developmental Genetics. In his own words
Below with Ed Lewis
#MustRead

Beautiful Lab!

Lates from the Briscoe lab: Lineage tracing of neural progenitors in 🐤& 👤 - demonstrates sequential binary decisions & persistence of spatial identity despite temporal competence changes.

Congrats to Giulia and co 🍾🥂

Brillante entrevista a Darío Lupiáñez, ganador del #JLGS2024. Inspiración y visión de un destacado integrante de nuestra sociedad. ¡Orgullo SEBD! @sebioldev.bsky.social Muy recomendable! No os la perdáis!

🤝¿Sabías que @elmundotoday.com ha iniciado una colaboración con el #CSIC?

Con este texto arrancaba (vía @csicdivulga.bsky.social) 👇
https://t.co/6SxyWUCAe5

Compared to other publishers, The Company of Biologists is small fry with fewer than 70 staff supporting 5 journals from a single office. But, for over 100 years now, it’s punched above its weight in innovation, prestige and community support.

And here is a layperson video summary of parts of our recent paper👇

Have fun!!
I heard that getting in is one of the biggest challenges of all times in science 🤣

This piece is a reminder of how organismal models can help shape our thinking. I’ve always admired how drosophilists and other model organism researchers put their work in context. No dichotomy drawn here with stem cell research, from my viewpoint!

Model organisms as platforms for training scientific minds

www.nature.com/articles/s41...

🔥 🔥 nice one!!

Penetrance and variant consequences—Two sides of the same coin? To get more out of genome sequences, the effects of variants need to be quantified

We can identify genetic associations with disease, but the hard part is figuring out what effects the variants at those loci actually do, including how penetrant they are. This is hard. But one phrase in this piece struck me in particular... /1
www.science.org/doi/10.1126/...

Systematic differences in protein stability underlie species-specific developmental tempo Human embryonic development proceeds more slowly than in mice. The segmentation clock offers a tractable model to study interspecies differences in developmental tempo, as its oscillation period in hu...

If you’re interested in this topic, please also check out @ebisuyamiki.bsky.social ky.social’s preprint.www.biorxiv.org/content/10.1...v2

Protein degradation shapes developmental tempo in mouse and human neural progenitors The pace of embryonic development differs markedly across mammalian species, yet the molecular mechanisms underlying these tempo differences remain largely unknown. Here, we systematically compared pr...

Collectively, we report species-specific differences in protein production and degradation rates and provide *in vivo evidence* that degradative machineries are less active in human embryos than in mice. Finally, we establish a causal role for protein degradation on dev. tempo.

👇👇

To test if we could accelerate differentiation tempo as well, we targeted the degradation of IRX3 via Halo tagging + HALO-PROTAC and show it accelerates OLIG2 expression.

So, we demonstrate that modulating protein stability can influence the expression of a downstream TF.

To test causality, we inhibited proteasomal activity.
Three day treatments with proteasomal inhibitors mostly killed the cells, BUT we observe signs of differentiation deceleration

This meant that degradative machineries may be in charge:
✔️ differential abundance & stability of proteasomal particles
✔️ higher proteasomal activity in 🐭 compared to 👤 embryonic spinal cord