The Global Neurodegeneration Proteomics Consortium: biomarker and drug target discovery for common neurodegenerative diseases and aging - Nature Medicine The largest harmonized proteomic dataset of plasma, serum and cerebrospinal fluid samples across major neurodegenerative diseases reveals both disease-specific and transdiagnostic proteomic signatures...

New multicohort resource for researchers exploring proteomics in neurodegenerative diseases — including data from the Whitehall II study. 🧠🔬

www.nature.com/articles/s41...

It was a pleasure to celebrate Whitehall II's 40th anniversary this month at UCL with Professor Sir Michael Marmot who set up the study in 1985. Watch the recording of the event here: www.youtube.com/watch?v=__gL...

Effectiveness of workplace interventions for health promotion Workplaces are an important setting for health promotion, offering established infrastructure, daily access to large populations, and opportunities to engage groups that are often under-represented in...

Workplaces are an important but underused channel for health promotion – a new review examines the most effective strategies.

www.thelancet.com/journals/lan...

2 new studies on weight loss
1. Sustained reduction during midlife improved survival and reduced chronic diseases jamanetwork.com/journals/jam...
2. A randomized trial found patient-to-patient care was more effective than professional for weight loss and less CV risk jamanetwork.com/journals/jam...

Weight Loss in Midlife, Chronic Disease Incidence, and All-Cause Mortality This cohort study investigates the association of sustained weight loss in midlife with long-term health benefits.

Long-term follow-up shows that losing weight in midlife—without surgery or medication—can lower the risk of chronic diseases later in life

jamanetwork.com/journals/jam...

My conversation with Sir John Bell, one of the most influential physician-scientists in the world.
(it's free, with transcript)
erictopol.substack.com/p/sir-john-b...

A state-of-the-art review with 1700+ references unpacks how systemic factors shape brain and vascular ageing—drawing on parabiosis, blood exchange and plasma transfer studies.

link.springer.com/content/pdf/...

Frailty-free life expectancy and its association with socio-economic characteristics: an analysis of the English Longitudinal Study of Ageing cohort study - BMC Medicine Background Frailty is more prevalent in socio-economically disadvantaged groups; however, little is known about how this translates to differences in the number of years people live with and without f...

A 10-year gap in frailty-free life expectancy between the highest and lowest socioeconomic groups.

link.springer.com/article/10.1...

Multiple recent studies, including 3 impressive natural experiments, consistently show a link between Shingles vaccines and reduced dementia. This week a nationwide S Korea study added a reduction of cardiovascular events
My summary Table. More here on dementia erictopol.substack.com/p/the-shingl...

A Doctor’s Science-Backed Formula for Aging Better Dr. Eric Topol’s research revealed it’s not so much genes that lead to long life but instead simple and practical steps to stay healthy. He’s taking his own advice.

Things with evidence that promote healthy aging, and I've adopted
gift link
www.wsj.com/health/welln...

This is figure 2, which shows SBP and DBP in the intervention and usual care groups over the 48 months of follow-up.

Reducing high blood pressure substantially lowers the risk of dementia and cognitive impairment without dementia, according to the results of a clinical trial published in Nature Medicine. go.nature.com/44z6kGy #medsky 🧪

This is figure 1, which gives an overview of cohort construction, model development and performance assessment for 10-year incident CAD risk meta-prediction in the UKBB.

A study in Nature Medicine shows that a meta-prediction framework integrating polygenic risk scores spanning multiple conditions and nongenetic factors had superior performance in predicting the 10-year risk of coronary artery disease. go.nature.com/4igXqAJ 🔒

The future burden of dementia in the US may be substantially lower than current projections.

Watch and learn more, then read the full JAMA Viewpoint on the changing story of the dementia epidemic. jamanetwork.com/journals/jam...

In case you follow me @X, my account was HACKED and someone is impersonating me selling bitcoin (and who knows what else to come).
Beyond that, all attempts to contact X to rectify the matter go nowhere.
If you have an account there, and get the chance, please post so people will know. Thanks!

Do viruses trigger Alzheimer’s? A growing group of scientists think so, and are asking whether antivirals could treat the disease

Do viruses play a role in the cause of Alzheimer's disease?
In the wake of observational studies showing some protection from the vaccines vs. shingles
www.economist.com/science-and-...
Unclear, but an ongoing clinical trial of valacyclovir, an anti-viral, may help to resolve

We've known social disadvantage was linked to adverse health outcomes. A @NatureMedicine study used high- throughput proteomics to show there is accelerated aging, increased risk of 66 age-related diseases, and unfavorable changes in the immune system, ⬆️ inflammation
www.nature.com/articles/s41...

Social disadvantage accelerates aging Nature Medicine - Individuals with social disadvantage, during both early and later life, have an increased risk of 66 age-related diseases mediated by 14 age-related proteins.

This multicohort study links social disadvantage to accelerated ageing, highlighting NF-κB activation as a key underlying mechanism.

#Aging #SocialDeterminants #NFkB

rdcu.be/edyqo

Direct and indirect impacts of the COVID-19 pandemic on life expectancy and person-years of life lost with and without disability: A systematic analysis for 18 European countries, 2020–2022 Sara Ahmadi-Abhari and colleagues explore the impact that the COVID-19 pandemic might have had on life expectancy and years of life lost, with and without disability, in 18 European countries. They ho...

New study on excess deaths during the COVID-19 pandemic across 18 European countries


–Countries with lower GDP saw a greater loss of years of life


–Higher vaccination coverage was linked to fewer years of life lost—independent of GDP

#PublicHealth #Vaccination

journals.plos.org/plosmedicine...

The person-years of life lost from the pandemic (here for Europe) with premature mortality reflects an underestimate of the toll of Covid @plos.org
journals.plos.org/plosmedicine...

Proteomic organ-specific ageing signatures and 20-year risk of age-related diseases: the Whitehall II observational cohort study Advanced proteomic organ ageing is associated with the long-term risk of age-related diseases. In most cases, faster ageing of a specific organ increases susceptibility to morbidity affecting multiple...

🔬Our latest research published in the Lancet Digital Health shows that different organs age at different rates, and that accelerated biological ageing is linked to a higher risk of age-related diseases—including multimorbidity across multiple organs.
www.thelancet.com/journals/lan...

Protein organ clocks, as assessed in over 6,000 people (~4,000 plasma proteins, 8 organs) with 20-year follow-up are predictive for over 30 age-related diseases
www.thelancet.com/journals/lan...

Integrating the environmental and genetic architectures of aging and mortality - Nature Medicine Based on a systematic analysis of environmental exposures associated with aging and mortality in the UK Biobank, the relative contributions of such exposures and genetic risk for mortality and a range...

Our lifestyle and environmental exposures are the predominant influencers of healthy aging and premature mortality, compared with polygenic risk, in the first comprehensive assessment
www.nature.com/articles/s41...
open-access

✅

Worth reposting!

Health benefits of leisure-time physical activity by socioeconomic status, lifestyle risk, and mental health: a multicohort study In addition to confirming the association between leisure-time physical activity and increased disease-free years across population subgroups, our findings show that these health benefits are often mo...

Engaging in leisure-time physical activity adds 1–2 extra disease-free years, with greater benefits among smokers, those with social disadvantage, and individuals with depression.
💡 Boosting physical activity may reduce health disparities.
Read more: www.thelancet.com/journals/lan...

Pathophysiology of clinical obesity

Redefining obesity, report of a new commission, to override current BMI categories and better define features and pathophysiologic consequences of pre-clinical and clinical obesity
www.thelancet.com/journals/lan... open-access

We have very limited means of tracking inflammation in the body, like a one-off hs-CRP blood test.
Today @science.org
Continuous real-time monitoring of inflammation and protein biomarkers in the body with a shaking sensor
science.org/doi/10.1126/...