Emilio Lecona

Congrats!

A comprehensive genetic catalog of human double-strand break repair The analysis of DNA sequence outcomes provides molecular insights into double-strand break (DSB) repair mechanisms. Using parallel in-pool profiling of Cas9-induced insertions and deletions (indels) w...

Kickstarting our Bluesky🦋 account with great news!
Our REPAIRome study finally out today in
@science.org
www.science.org/doi/10.1126/...

Es increíble

Looking for scientists working with long-read transcriptomics technologies to join a COST action proposal. Contact us!!! @nanoporetech.com @pacbio.bsky.social

Os cuento una situación habitual que he vivido hoy con mis hijas, pero que por algunos detalles me parece llamativa.
Íbamos en el bus camino al colegio, mis hijas (5 y 7) estaban jugando entre ellas.
En una parada ha subido una amiga de la pequeña, con su madre y su hermano gemelo.

YouTube video by Centro de Biología Molecular Severo Ochoa Cincuentenario del Centro Biología Molecular Severo Ochoa - Decoding life

🎥🔬 50 años descodificando la vida.
Descubre en este video cómo el CBM ha marcado la biomedicina en España y el mundo, formando talento y generando ciencia de impacto.
#CincuentenarioCBM #DecodingLife youtu.be/7bzJOIW5kyM

🎨🔬 ¡La ciencia también se puede contemplar!
Durante el Golden Jubilee Symposium del CBM inauguramos nuestra exposición de imágenes científicas, que muestra la belleza de la investigación. Desde microbiología, virología hasta metabolismo y estabilidad genómica #CincuentenarioCBM

Un placer y un privilegio participar en esta mesa redonda, rodeado de grandes científicos y celebrando los 50 años del @cbm-csic-uam.bsky.social

Scientists reflected on running DNA.

We have an open post-doc position in my group to study mRNA cleavage and polyadenylation using biochemical reconstitution and cryoEM.

Please get in touch if you are interested in joining this amazing team! 🔬🧬🤩
#RNA #cryoEM

Buenas, cuánta gente de aquí tiene una higuera?? Se está haciendo un estudio en la USC y piden nuestra ayuda. Las quieren de donde sea, Galicia, España y Europa. Yo le mandaré de la mía y posiblemente de algún vecino (si me dejan). Animaos vosotros también

in retrospect, it was a mistake to teach algebra and geometry but not "statistics for everyone" in high school

we are drowning in lies, partly because we never learned to swim

🔬✨ ¡La ciencia sale a la calle! Este 26 de septiembre, la Noche Europea de l@s Investigador@s te espera en Espacio Fundación Telefónica. Talleres, experimentos, yincana, talent show y música para todas las edades.
#NIGHTMADRID @csic.es
Más info: www.icmm.csic.es/es/noche-noc...

u know who are skeptics
scientists are skeptics

being anti-science is not being a skeptic

La más grande.

Cubist Cell — where biology meets Picasso.
A nucleus, mitochondria, and ER reimagined through fractured planes and bold geometry.
#CellBiology

I would see that as an upgrade.

Postdocs rejoice: the found life on Mars, which suggests a potential job market! 🧪

There would be an inordinate amount of unpleasantness and suffering avoided if 2025 folk could understand the difference between:

I like this!

and

Everyone HAS to love this!

I supervise an excellent postdoc who's looking for a postdoc or associate position in < 1 yr. Highly skilled in chem biol and biochem (peptide synthesis, native chem ligation, bacterial expression, purification, intein-based splicing, crystallography, interaction assays). Contact me if interested.

A dark screenshot of a tweet from a verified account. A small headshot appears at top left. White text on navy background reads: There is a reason you separate military and the police. One fights the enemies of the state, the other serves and protects the people. When the military becomes both, then the enemies of the state tend to become the people. Admiral William Adama. Timestamp 11:03 PM, 6 1 20, sent via Twitter for iPhone.

I think that’s their plan.

Image of Toronto

JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.

www.nature.com/naturecareer...

Please repost!

Un tipo llamado Fred Sanger - Gen-Ética Este verano hemos pasado unos días en Cambridge (Reino Unido), ciudad universitaria por excelencia y sede de prestigiosos e históricos centros de investigación. Estos centros convierten a Cambridge en...

Un tipo llamado Fred Sanger montoliu.naukas.com/2025/08/24/u...
Gracias 🙏🏼 @lluismontoliu.bsky.social por este excelente artículo sobre Sanger, un admirable y singular científico cuya vida nos enseña una vertiente imprescindible de la verdadera ciencia y cuánto nos hemos alejado de ella.

One of my favourite things about torcs, is that the word comes from the Latin word torquere (tor-kwe-ray) meaning twist, bend or torture.

This is also where we get the word 'queer'.

So even in its origin, queer meant twisted and wrong, as well as something shiny and fabulous.

Dear Fly Community, In May 2025, the NIH terminated all grant funding to Harvard University, including the NHGRI grant that supported FlyBase. This grant also funded FlyBase teams at Indiana University (IU) and the University of Cambridge (UK), and as a result, their subawards were also canceled. The Cambridge team has secured support for one to two years through generous donations from the European fly community, emergency funding from the Wellcome Trust, and support from the University of Cambridge. At IU, funding has been secured for one year thanks to reserve funds from Thom Kaufman and a supplement from ORIP/NIH to the Bloomington Drosophila Stock Center (BDSC). Unfortunately, the situation at Harvard is far more critical. Harvard University had supported FlyBase staff since May but recently denied a request for extended bridge funding. As a result, all eight employees (four full-time and four part-time) were abruptly laid off, with termination dates ranging from August to mid-October depending on their positions. In addition, our curator at the University of New Mexico will leave her position at the end of August. This decision came as a shock, and we are urgently pursuing all possible funding options. To put the need into perspective: although FlyBase is free to use, it is not free to make. It takes large teams of people and millions of dollars a year to create FlyBase to support fly research (the last NHGRI grant supported us with more than 2 million USD per annum). To help sustain FlyBase operations, we have been reaching out to you to ask for your support. We have set up a donation site in Cambridge, UK, to which European labs have and can continue to contribute, and a new donation site at IU to which labs in the US and the rest of the world can contribute. We urge researchers to work with their grant administrators to contribute to FlyBase via these sites if at all possible, as more of the money will go to FlyBase. However, we appreciate that some fu…

https://wiki.flybase.org/wiki/FlyBase:Contribute_to_FlyBase Our immediate goals are: 1. To maintain core curation activities and keep the FlyBase website online 2. To complete integration with the Alliance of Genome Resources (The Alliance). Integration with the Alliance is essential for FlyBase’s long-term sustainability. For nearly a decade, NHGRI/NIH has supported the unification of Model Organism Databases (MODs) into the Alliance, which we aim to achieve by 2028. Therefore, securing bridge funding to sustain FlyBase over the next three years is crucial for successful integration and the long-term access to FlyBase data. At present, our remaining funds will allow us to keep the FlyBase website online for approximately one more year. Beyond that, its future is uncertain unless new funding is secured. We will, of course, continue pursuing additional grant opportunities as they arise. Given the uncertainty of future NIH or alternative funding sources, we are relying on the Fly community for support. Your contributions will directly help us retain the staff needed to complete this transition and to secure ongoing fly data curation into the Alliance beyond 2028. We at FlyBase are incredibly grateful for the outpouring of support from the community during this challenging time. Your encouragement has strengthened our resolve and underscores how vital this resource remains to Drosophila research worldwide. Sincerely, The FlyBase Team

The community of Drosophila researchers is amazing, mutually supportive and collaborative. Right now a key resource for our community, @flybase.bsky.social , is threatened by the cancellation of its NIH grant and is seeking community help in raising short term funds 1/n 🧪 please share

A pesar de que la comunidad negra de Texas es la que está produciendo un aumento considerable de población en ese estado, la Asamblea de Representantes en Austin ha aprobado cambiar la configuración de los distritos electorales para intentar que en las elecciones 2026 ganen solo candidatos blancos.👇

It is not always safe to repair DNA Damage. Sometimes, cells "just bypass it".

During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication.

Read our review and find out why and how: doi.org/10.1016/j.ti...

USP1/UAF1 targets polyubiquitinated PCNA with an exo-cleavage mechanism that can temporarily enrich for monoubiquitinated PCNA - Nature Communications DNA damage tolerance is regulated by ubiquitination of PCNA. Here, the authors present kinetic and structural studies showing that USP1/UAF1 prefers trimming K63- and K48-ubiquitin chains down over cl...

New cool research alert!

Tita Sixma #RepliFate lab uncovered the preferred exo-cleavage mechanism by which USP1/UAF1 can cleave ubiquitin chains on polyubiquitinated PCNA and temporarily enrich for monoubiquitinated PCNA.

Read the full study: doi.org/10.1038/s414...

¡Enhorabuena!

PhD student to study the mechanisms and therapeutic potential of genomic instability

Aspiring PhD students, this is your chance to join us at the NKI to work on genomic instability and telomeres!: www.werkenbijavl.nl/vacatures/ph...