In conclusion:
- From a patient perspective, high-dose PQ and TQ is warranted
- From a community perspective, low-dose and high-dose drug regimens will cause similar reductions in P. vivax transmission
Ensuring high drug safety, adherence and coverage is key to maximising PQ and TQ impact.
27.01.2025 10:06 β π 2 π 0 π¬ 0 π 0
We quantified the community-level impact of routinely treating symptomatic P. vivax cases with PQ or TQ using an existing agent-based model.
- All regimens can achieve a similar impact
- Drug adherence and eligibility criteria hamper impact
- Impact decreases with increasing transmission intensity
27.01.2025 10:06 β π 3 π 0 π¬ 1 π 0
We estimated the patient-level efficacy of PQ and TQ by calibrating a novel mathematical model to clinical trial data.
- Effective treatment can eliminate almost all P. vivax hypnozoites
- PQ and TQ regimens have differing efficacies
27.01.2025 10:06 β π 0 π 0 π¬ 1 π 0
Unlike the more common P. falciparum, P. vivax forms dormant liver stage parasites (hypnozoites) that can reactivate weeks to months after primary infection to cause recurrent infections.
The efficacy of liver-stage drugs PQ and TQ cannot be estimated directly because hypnozoites are undetectable.
27.01.2025 10:06 β π 0 π 0 π¬ 1 π 0
Postdoc (Montpellier, France)
Mathematical modelling of Plasmodium vivax malaria
with @conniciavarella.bsky.social
at @umontpellier.bsky.social
More details: http://iddjobs.org/jobs/2236
24.01.2025 20:36 β π 7 π 3 π¬ 0 π 1
Postdoc (Montpellier, France)
Mathematical/statistical modelling of respiratory virus transmission
with @conniciavarella.bsky.social; @mtsofonea.bsky.social
at @umontpellier.bsky.social
More details: http://iddjobs.org/jobs/2237
24.01.2025 20:38 β π 8 π 5 π¬ 0 π 0
PhD Candidate (Lab : https://www.evmodelers.org/) | Infectious Disease Modelling | L'Γ©cole doctorale Pierre Louis de SantΓ© Publique | Sorbonne Centre for Artificial Intelligence (SCAI)
Combining #deeplearning with mathematical models of infectious diseas
Assistant Professor UCLouvain.
Infectious diseases modelling, social contacts, network epidemiology.
Reporter for Nature news, covering the Asia-Pacific region, including infectious diseases, biological and environmental sciences, and community stories (smritidotmallapatyatnaturedotcom) Find me on Signal at sfm.100
Physicist. Full Professor at University of Zaragoza & GoThAM Lab @gotham-lab.bsky.social.
Research on Dynamical Systems and Complex Systems applied to Evolution, Epidemics, Social Behaviors, Sync & much more
Website: http://complex.unizar.es/~jesus/
Epidemiology PhD candidate, interested in disease dynamics and novel surveillance systems
Assistant prof at UGA in Epi/Bios, disease modeler, and data scientist. Posts are my own opinions
Professor at Memorial University. Biology Dept, and Mathematics & Statistics Dept. Theoretical Ecology, Evolution and Epidemiology.
DVM PhD | Disease ecologist | Postdoctoral fellow at Notre Dame | she/her
Professor of Mathematical Sciences, working mainly on epidemiology although partial to a bit of non-commutative algebra, social science and basic biology.
https://personalpages.manchester.ac.uk/staff/thomas.house/about.html
Professor, evolution of drug resistance, modeling, population genetics, coding, SF State University, mom, Dutch
Infectious disease modeller at Institut Pasteur
PhD in Environmental Health Sciences πΏ Infectious Disease Eco-Epidemiology πΏOne Health πΏ Environmental Justice
McKenzie Research Fellow at the University of Melbourne. Mathematical modelling of infectious disease dynamics.
Infectious disease physician, post-doc at Institut Pasteur Paris, IDEA Unit. Research on the epidemiology and immunology of vector borne infections, mainly malaria and arboviruses
Professor, UW Biology / Santa Fe Institute
I study how information flows in biology, science, and society.
Book: *Calling Bullshit*, http://tinyurl.com/fdcuvd7b
LLM course: https://thebullshitmachines.com
Corvids: https://tinyurl.com/mr2n5ymk
he/him
Postdoc in @aleksdelab.bsky.social at @pasteur.fr
European Research Council, set up by the EU, funds top researchers of any nationality, helping them pursue great ideas at the frontiers of knowledge. #HorizonEU
2nd year PhD Student at Institut Pasteur in the G5 - Michael White - Infectious Disease, Analytics & Epidemiology
Development of serological assay for surveillance of arboviruses using Luminex Technology
Assoc Prof at Imperial College London and at LSHTM
Respiratory viruses, bayesian inference, evidence synthesis, vaccines, outbreak analysis, photographer, urban gardener.