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Conni Ciavarella

@conniciavarella.bsky.social

Research fellow in mathematical modelling of infectious diseases, Montpellier University

93 Followers  |  81 Following  |  5 Posts  |  Joined: 14.01.2025  |  1.3923

Latest posts by conniciavarella.bsky.social on Bluesky

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Postdoctoral positions in epidemic mathematical/statistical modelling - Research Job description We are recruiting postdocs to contribute to research projects in the Mathematical Modelling of Infectious Diseases Unit, at Institut Pasteur in Paris. The candidates will be expected t...

New postdoc positions with a number of exciting epidemic modelling projects opening in our Unit at @pasteur.fr in beautiful Paris. Deadline for applications: 26th June.
research.pasteur.fr/en/job/postd...

05.06.2025 05:22 β€” πŸ‘ 55    πŸ” 66    πŸ’¬ 0    πŸ“Œ 3

In conclusion:

- From a patient perspective, high-dose PQ and TQ is warranted
- From a community perspective, low-dose and high-dose drug regimens will cause similar reductions in P. vivax transmission

Ensuring high drug safety, adherence and coverage is key to maximising PQ and TQ impact.

27.01.2025 10:06 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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We quantified the community-level impact of routinely treating symptomatic P. vivax cases with PQ or TQ using an existing agent-based model.

- All regimens can achieve a similar impact
- Drug adherence and eligibility criteria hamper impact
- Impact decreases with increasing transmission intensity

27.01.2025 10:06 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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We estimated the patient-level efficacy of PQ and TQ by calibrating a novel mathematical model to clinical trial data.

- Effective treatment can eliminate almost all P. vivax hypnozoites
- PQ and TQ regimens have differing efficacies

27.01.2025 10:06 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Unlike the more common P. falciparum, P. vivax forms dormant liver stage parasites (hypnozoites) that can reactivate weeks to months after primary infection to cause recurrent infections.

The efficacy of liver-stage drugs PQ and TQ cannot be estimated directly because hypnozoites are undetectable.

27.01.2025 10:06 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
Preview
Quantifying Plasmodium vivax radical cure efficacy: a modelling study integrating clinical trial data and transmission dynamics Substantial reductions in prevalence as measured by PCR were predicted with primaquine and tafenoquine regimens if these could be implemented with high coverage and adherence. The benefits of preventi...

New paper out in The Lancet Infectious Diseases!

This paper answers questions around the efficacy of primaquine (PQ) and tafenoquine (TQ) against P. vivax malaria.

www.thelancet.com/journals/lan...

27.01.2025 10:06 β€” πŸ‘ 10    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0

Postdoc (Montpellier, France)
Mathematical modelling of Plasmodium vivax malaria
with @conniciavarella.bsky.social
at @umontpellier.bsky.social
More details: http://iddjobs.org/jobs/2236

24.01.2025 20:36 β€” πŸ‘ 7    πŸ” 3    πŸ’¬ 0    πŸ“Œ 1

Postdoc (Montpellier, France)
Mathematical/statistical modelling of respiratory virus transmission
with @conniciavarella.bsky.social; @mtsofonea.bsky.social
at @umontpellier.bsky.social
More details: http://iddjobs.org/jobs/2237

24.01.2025 20:38 β€” πŸ‘ 8    πŸ” 5    πŸ’¬ 0    πŸ“Œ 0

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