Simran Gupta

Very excited for this next (and last) stage of my training! We’re moving to New York!

Antagonistic interaction between posaconazole and olorofim in a murine model of invasive pulmonary aspergillosis AbstractBackground. Olorofim is a new antifungal agent with a novel mechanism of action with in vitro activity against Aspergillus fumigatus and other clin

Antagonistic interaction between posaconazole & olorofim in a murine model of invasive pulmonary aspergillosis

Posaconazole ⬇️ the effect of olorofim in vivo. Combination of olorofim+azole likely efficacious in wt infections, may be suboptimal in azole R infections

academic.oup.com/jac/article/...

Ah yes, the famously medium-spectrum doxycycline.

It only covers
Staphylococci
Pneumococci
Beta haemolytic Streptococci
Actinomyces
Mycoplasma
Chlamydophila
Legionella
H.influenzae
Moraxella catarrhalis
ESBL E.coli UTI
Pseudomonas UTI(maybe!)
Burkholderia pseudomallei
Vibrio
H.pylori

1/2

TLDR; We propose an optimized ASE 2.0 definition:
- allow POA infection diagnosis codes to anchor infection
- include pts discharged alive on QAD 3
- include hypotension w/out pressors (>/= 2 readings in 6h)
- include NIV or HFNC (>/= 2 days)
- minor changes in Plt, Cr, and Tbili thresholds

Good perspective from @simrangmd.bsky.social et al re use of PCT in ICU.

Particularly pertinent that as data and practice keep pointing towards shorter antibiotic course therapy, the window for diagnostic stewardship will narrow, limiting PCT benefit.
#IDSky #ClinMicro #AMR

Check out our viewpoint!

This is by far the most common vaccine I strongly recommend in ID adult clinical practice. As ID doctors, we see some truly severe cases of zoster, with post-zoster sequelae that may last months or even rarely be permanent. #IDSky doi.org/10.1093/cid/...

Procalcitonin-guided care cut antibiotic use by 1 day in sepsis patients but had no mortality impact. CRP showed no benefit. Adherence was low; future focus on early biomarker use is needed. 📉💊

#idsky

Herpes Zoster Vaccination and Dementia Occurrence

Herpes zoster vaccination eligibility reduced the probability of new dementia diagnoses, suggesting its potential preventive effect.

https://ja.ma/4lagSB6

🍾Last evening, the MGH & BWH ID faculty celebrated graduates of the MGB ID & MGH Transplant ID Fellowships, along with their families. It was a heartwarming celebration of stories, accolades, laughter, and tears. Special thanks go to our featured speakers Dr. Eric Rubin & Dr. Gabriel Motoa Cardona.🤩

Last few weeks with this BWH crew! @mgb-id-fellows.bsky.social

Social Media Savvy, It's More Than Just the #Hashtags: How the Use of Social Media in Transplant Infectious Diseases Can Impact the Field and Patients

‼️Our new paper on social media in #TxID is officially out in @thetxidjournal.bsky.social

We summarize findings from our #TxIDChat @txidfellows.bsky.social

We discuss recs for trainees, career advancement, & future directions in this changing landscape. Check it out!

dx.doi.org/10.1111/tid....

Trump Pauses Disbursements to Program Supplying H.I.V. Treatment Worldwide Pepfar, which is estimated to have delivered lifesaving treatment as many as 25 million people in 54 countries, faces a funding delay of as long as 180 days.

This will kill so many people living with HIV who depend on PEPFAR programs to stay on their HIV treatment driving further HIV drug resistance.

www.nytimes.com/2025/01/24/u...

ICE was in my hospital today…

i am so beyond angry—this is unacceptable

stay away from our patients and let us do our jobs

CDC's Morbidity and Mortality Weekly Report (MMWR) has provided real-time data and analysis about disease outbreaks and emerging health threats without a break every week since 1960.

Until today.

Trump's Gag Order Halts CDC Publication MMWR did not publish as usual at 1 p.m. today

Trump's Gag Order Halts CDC Publication www.medpagetoday.com/infectiousdi... For the first time in its more than 60-year history, the CDC's Morbidity and Mortality Weekly Report (MMWR) did not go out as scheduled.

Scientific advancements aside, this is economically irresponsible

Every $1 spent by NIH generates $2.46

For example, in 2023, $47B in NIH spending generated ~$93B

Halting NIH spending will LOSE the US a lot of money (and talent)

For those asking how unusual it is for NIH review panels to be cancelled: I do not recall study sections ever being cancelled during my 30-year career except for during the “sequestration” period around 2012-2013 when there was, I think, a government shutdown.

Oh. My.

Outcomes of Coccidioides Seropositive Solid Organ... : Transplantation by enzyme immunoassay (EIA-IgM-only), although this result may be falsely positive. Methods. We conducted a retrospective study at a large-volume transplant center in an endemic coccidioidomycosis ...

Excited to share our research on duration of antifungal ppx for Cocci in SOT!

TLDR; For patients repeatedly pos for EIA-IgM-only w no seroconversion, compatible clinical illness, or rads findings, discontinuing antifungal ppx may be reasonable after 1st posttxp yr

journals.lww.com/transplantjo...

Time to Staphylococcus aureus Blood Culture Positivity as a risk marker of Infective Endocarditis: A Retrospective Cohort Study Short time to blood culture positivity (TTP) was an independent risk factor of infective endocarditis in this large (N=1703) Staphylococcus aureus bacterem

🆕💫Retrospective Cohort Study
Time to Staphylococcus aureus Blood Culture Positivity as a risk marker of IE
Short TTP was associated wit IE
NPV >95% suggests that TTP>13h can be used to risk stratify pts with SAB #idsky #EMIMCC
academic.oup.com/cid/article/...
academic.oup.com/cid/advance-...

Yersinia enterocolitica Pneumonia in a Heart Transplant Recipient Click on the article title to read more.

Did you know that Yersinia can cause pneumonia? It sure can. Check out this interesting report by @carlosportales.bsky.social @agstewart.bsky.social onlinelibrary.wiley.com/doi/10.1111/...

Social Media Savvy, It's More Than Just the #Hashtags: How the Use of Social Media in Transplant Infectious Diseases Can Impact the Field and Patients

🔥Out now! Our latest from @txidfellows.bsky.social on the use of social media in #TxID. doi.org/10.1111/tid.... @courtharrismd.bsky.social @rebeccakumar.bsky.social @germhuntermd.bsky.social @paulsaxmd.bsky.social @transplantid.bsky.social

Published on This Day in 1981. Pneumocystis carinii Pneumonia and Mucosal Candidiasis in Previously Healthy Homosexual Men — Evidence of a New Acquired Cellular Immunodeficiency An illustration showing the reproductive cycle of human immunodeficiency virus type 1 (HIV-1) and sites of action of the major classes of antiretroviral medications. The NEJM identity sits at the bottom.

On this day in 1981, a landmark paper in NEJM described four patients with evidence of immunodeficiency associated with PJP pneumonia, disseminated CMV, and Kaposi sarcoma. The disease would come to be known as HIV/AIDS. Revisit the paper: nej.md/41iekKD

#MedSky #IDSky

🤩 WE ARE SUPER EXCITED to announce our 2025-2027 class of ID Fellows! 🥂

We are thrilled to have matched with such a talented group!

7-year performance of a clinical mNGS test for diagnosis of CNS infections

Sensitivity 63.1%
Specificity 99.6%
Accuracy 92.9%

4 potential use cases:
➡️unculturable, difficult-to-diagnose organisms
➡️broadly dx viral infections
➡️rare, unexpected infections
➡️outbreaks

doi.org/10.1038/s415...

#IDSky