George Burslem

A Potent Inhibitor of Caspase-8 Based on the IL-18 Tetrapeptide Sequence Reveals Shared Specificities between Inflammatory and Apoptotic Initiator Caspases Caspases are a family of cysteine proteases that act as molecular scissors to cleave substrates and regulate biological processes, such as programmed cell death and inflammation. Extensive efforts hav...

New paper online at ACS Bio & Med Chem Au with @taabaman.bsky.social! New peptide probes and inhibitors for caspase 8
pubs.acs.org/doi/10.1021/...

I’ve been many times and always leave feeling this way!

Juneteenth is a story of freedom hard-won & resilience hard-kept—honoring Black history & the ongoing fight for justice. At Penn Medicine, Research Trainee Affairs advances discovery rooted in respect, access & opportunity—values that shape our comprehensive education, training & outreach mission.

Truly grateful and honored to have had the opportunity to share my work at the Bioorganic GRC and represent the Burslem lab 💙

Congratulations to @briehp.bsky.social who gave an awesome Knowles award talk at the Bioorganic GRC! Very proud PI!

Molecular basis of influenza ribonucleoprotein complex assembly & processive RNA synthesis ft. Ruchao Peng, Xin Xu, Yikang Gong, Fenglin Li, Max Ferretti, Mingyang Zhou, Kristen Lynch, @gburslem.bsky.social, @MarmorsteinLab & @yiweichang.bsky.social (@BB_Upenn) www.science.org/doi/10.1126/...

Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis Influenza viruses replicate and transcribe their genome in the context of a conserved ribonucleoprotein (RNP) complex. By integrating cryo–electron microscopy single-particle analysis and cryo–electro...

Excited to share our new @science.org paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals.
www.science.org/doi/10.1126/...

Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis Influenza viruses replicate and transcribe their genome in the context of a conserved ribonucleoprotein (RNP) complex. By integrating cryo–electron microscopy single-particle analysis and cryo–electro...

Congratulations to Drs. Lynch, Burslem, Marmorstein, Yi-Wei, and the entire research team on the publication of your latest research article in the newest issue of Science magazine! | Science www.science.org/doi/10.1126/...

Intracellular protein editing & noncanonical residues in endogenous proteins ft. J. Beyer, K. Toy, M. Najar, N. Raniszewski, @gburslem.bsky.social (@BB_UPenn), @ysereb.bsky.social, @efeierman.bsky.social, @korblab & @ophirshalem.bsky.social (@penngenetics.bsky.social) www.science.org/doi/10.1126/...

Feel free to reach out anytime!

Oh no! Sorry! We want people to read it but not at the expense of getting home! We’ll make sure to write less interesting papers from now on 🤣

Powerful protein editors offer new ways of probing living cells Scientists deploy self-splicing protein subunits to insert strange new additions into target proteins.

News and Views in @nature.com too with comments from @miketilapia.bsky.social
www.nature.com/articles/d41...

Editing proteins inside a cell Pairs of split protein segments can modify a variety of target proteins in a living cell

Great collaboration with @ophirshalem.bsky.social and @korblab.bsky.social labs and thanks to Wenshe Liu for writing an excellent news and views www.science.org/doi/10.1126/...

Excited to see this out in @science.org today!! www.science.org/doi/10.1126/...

Trump Has Now Deported Multiple U.S. Citizen Children With Cancer Two families who had lived in the United States for years, including a child with cancer and a pregnant mother, were deported by ICE on Friday.

Honestly, if there is just one article that you are going to share far-and-wide today, it's this one:

'Trump Has Now Deported Multiple U.S. Citizen Children With Cancer'

The headline says it all, and everyone needs to know about this.

www.rollingstone.com/politics/pol...

Thrilled to see our work now in @cp-molcell.bsky.social! It was an incredible privilege to do my postdoc with @ophirshalem.bsky.social and work alongside the super talented Steph Sansbury and our amazing co-authors. Excited to keep building on this research in our new lab at @rwjms.bsky.social!

Pooled tagging and hydrophobic targeting of endogenous proteins for unbiased mapping of unfolded protein responses Sansbury and Serebrenik et al. use pooled gene tagging with in situ sequencing and high-throughput image analysis to generate a cell pool with endogenous HaloTag fusions. Hydrophobic targeting is then...

Check out our paper, now extensively revised and published in @cp-molcell.bsky.social! This has been a real tour de force led by Stephanie Sansbury and @ysereb.bsky.social and we are very excited about the findings and future potential of this approach
www.cell.com/molecular-ce...

Research Technician - Open Chemistry Primary Work Address: 19700 Helix Drive, Ashburn, VA, 20147 Current HHMI Employees, click here to apply via your Workday account. Summary: Open Chemistry is a collaborative research group whose missio...

We're looking for 1-2 enthusiastic early career chemists to join our Open Chemistry team at @hhmijanelia.bsky.social. Come help us create amazing dyes and share them with the world. Please share with the best recent/soon-to-be B.S. chemists you know! bit.ly/42w8C6N

Great news: NIH postbac program is recruiting again! If your grad school plans were affected by program cutbacks or admissions freezes this year I highly encourage you to apply, this could be a perfect opportunity. Please repost.

www.training.nih.gov/research-tra...

Excited to be co-chairing the Chemical tools to reveal new biology theme with @davidlabmsk.bsky.social!

I am sending so much love to my colleagues at NIH today. They are incredible people and scientists and don’t serve any of this. 💔

Reversible histone deacetylase activity catalyzes lysine acylation - Nature Chemical Biology Tsusaka et al. discover that histone deacetylases, which are well known to remove protein modifications, such as lysine acetylation and β-hydroxybutyrylation, can also reverse their chemical activity ...

My favorite science is the kind that makes you says, "Man, I wish I thought of that!" This is such a paper.

Mass action turns an eraser into a pen. HDACs are metabolite-dependent histone acyltransferases.

@dremilygoldberg.bsky.social @gburslem.bsky.social

www.nature.com/articles/s41...

Non-canonical acylation of lysine residues catalyzed by HDACs! Congratulations to @dremilygoldberg.bsky.social for such beautiful work and thanks for bringing us along for the ride!

Excited to report our latest research on new “molecular glues” that specifically lock the BRCC36 isopeptidase complex (BRISC) in an autoinhibited state and reduce interferon signalling. This first-of-its-kind approach could reshape how we target large deubiquitylase (DUB) complexes.

rdcu.be/edRwF

This will also help you find people outside your circle who are also fighting. Pick a cause you care about, find a group or event, and just show up. You'll realize you are not alone, not even close

I’ll be there.

There is a war on science happening.

I intend to fight back.

Acetylation: a new target for protein degradation in cancer Acetylation is an increasing area of focus for cancer research as it is closely related to a variety of cellular processes through modulation of histo…

New paper online today! Check out @cewc9.bsky.socials review on how acetylation mediated protein degradation impacts cancer! Thanks for the invite to contribute to the 10th anniversary special issue of Trends in Cancer! www.sciencedirect.com/science/arti...

Class I histone deacetylases catalyze lysine lactylation Metabolism and post-translational modifications (PTMs) are intrinsically linked and the number of identified metabolites that can covalently modify proteins continues to increase. This metabolism/PTM ...

Two new preprints online today!

One with @dremilygoldberg.bsky.social on lysine lactylation
www.biorxiv.org/content/10.1...

Another with @taabaman.bsky.social on new peptide tools to study caspases www.biorxiv.org/content/10.1...

Class I histone deacetylases catalyze lysine lactylation Metabolism and post-translational modifications (PTMs) are intrinsically linked and the number of identified metabolites that can covalently modify proteins continues to increase. This metabolism/PTM ...

I'm excited to share our new preprint @biorxivpreprint.bsky.social describing what we think is the dominant mechanism of lysine lactylation. HDACs operating in reverse!! Great collab with @gburslem.bsky.social and @mzspectrum.bsky.social
www.biorxiv.org/content/10.1...

We have a postdoc position available for a very cool collaborative project! Synthetic chemistry expertise is a must!
Unfortunately due to the funding source, this position is only available to US citizens or permanent residents.

chemistryjobs.acs.org/job/postdoct...