Christian Schlieker

Good stuff!

looking forward to hosting Aaron Gitler @yalembb.bsky.social @yaleschoolofmed.bsky.social next Monday!

O'zapft is!
Great times at our Octoberfest @yalembb.bsky.social yesterday with perfect weather and amazing home-brew!

2025 Winners - Lasker Foundation winners

Learn more about all the 2025 #LaskerAward winners—Dirk Görlich & Steven L. McKnight; Michael J. Welsh, Jesús (Tito) González, & Paul A. Negulescu; Lucy Shapiro 🧪
#Lasker2025
📖: laskerfoundation.org/winners/2025...
👀: laskerfoundation.org/the-2025-las...

FOMO no more: NOMO and Calmin extend #mechanobiology to the ER. Julie Heffler and Jan Lammerding @LammerdingLab.bsky.social discuss recent studies from the @schliekerlab.bsky.social (doi.org/10.1083/jcb....) & @hennelab.bsky.social (doi.org/10.1016/j.ce...), in Spotlight: rupress.org/jcb/article/...

Heffler and @LammerdingLab.bsky.social discuss recent studies from the @schliekerlab.bsky.social (doi.org/10.1083/jcb....) and @hennelab.bsky.social (doi.org/10.1016/j.ce...) that identify two proteins serving as crucial mechanical elements in the endoplasmic reticulum. rupress.org/jcb/article/...

Thank you indeed-great read and excellent discussion on our recent papers identifying molecular mechanisms that (I) connect cellular forces to organelles and (II) enable elaborate membrane systems to respond to mechanical challenge

Congrats!!

Congrats Kim et al!

Cell state-specific cytoplasmic density controls spindle architecture and scaling Nature Cell Biology - Kletter et al. show that cell state-specific cytoplasmic density controls spindle architecture and scaling in neural differentiation, suggesting that the physical properties...

✨Thanks to amazing students @tobiaskletter.bsky.social, postdocs @biswashere.bsky.social & collaborators @vasilyzaburdaev.bsky.social‬ & ALMF @embl.org ✨

👉Cytoplasmic material properties control spindle architecture and scaling 👉 out today @natcellbio.nature.com rdcu.be/eqPr8

our genome-wide CRISPR screen revealed strong ties between microcephaly-related genes and aberrant condensates revealing unexpected cellular pathology! Our chemical-genetic platform could accelerate the hunt for treatments for neurodegenerative and neurodevelopmental disorders!

🔬 Key findings:
-RNF26 and ZNF335 protect against harmful protein buildup.
-identification of compounds that have potential to counteract toxic condensates.
-Links to zinc biology, autophagy, and oxidative stress offer new therapeutic angles.

We’ve pioneered a disease-agnostic screening platform for aberrant biomolecular condensates—cellular structures linked to incurable neurological diseases. We screened genes and FDA-approved drugs that modulate disease-relevant nuclear condensates: www.biorxiv.org/cgi/content/...

we are beyond proud that our @yalembb.bsky.social @schliekerlab.bsky.social undergraduate researcher Sophia graduated as the sole @Yale Colleague '25 graduate with an exceptional distinction in the major! Congrats Sophia for this richly deserved honor!

Spatial proteomics of ER tubules reveals CLMN, an ER-actin tether at focal adhesions that promotes cell migration The endoplasmic reticulum (ER) is structurally and functionally diverse, yet how its functions are organized within morphological subdomains is incomp…

Important to celebrate trainee victories: excited to have Holly Merta's @hollymerta.bsky.social paper out!

We use TurboID sub-organelle proteomics to map the ER network.

We find calmin/CLMN, an ER-to-actin tether regulating focal adhesions & cell motility.

www.sciencedirect.com/science/arti...

Enjoying warmer weather around low tide

We are excited to announce a tenure-track or tenured faculty position in Computational Biophysics and Biochemistry, exploring the intricate molecular and cellular processes and the complex interactions of their macromolecular components. Join us in MB&B!

Apply now at apply.interfolio.com/162132

In a great collaboration with @hummerlab.bsky.social and the Kräusslich lab: HIV capsid doesn't break at the NPC; instead, it cracks open the NPC itself! Details in Cell: authors.elsevier.com/sd/article/S... @mpibp.bsky.social @uniheidelberg.bsky.social A thread below:

Mechanistic basis of temperature adaptation in microtubule dynamics across frog species Despite tubulin’s evolutionary conservation, microtubule dynamics are highly temperature sensitive. Troman et al. use natural tubulin variants from closely related Xenopus species to show that a decrease in tubulin’s apparent activation energy and weakening of lateral lattice contacts stabilize microtubules in cold-adapted frogs.

How did microtubules adapt to support life across 🐸 species at divergent thermal niches? 


Now online & OA @currentbiology.bsky.social

Thanks to Ella, Luca, @biswashere.bsky.social & Carolyn @mpiib-berlin.mpg.de @BirkbeckUoL
 🙌

Enjoy reading! 👉 www.cell.com/current-biol...