Masnun Naher

A recent review by Solomon and Keaveney et al. reveals how catalyst structure controls the crucial transmetalation step in Pd- and Ni-catalysed cross-couplings, advancing the understanding of modern catalysis. #AusJChem #openaccess
@csiropublishing.bsky.social

www.publish.csiro.au/ch/pdf/CH25103

Complexes of binucleating ligands. III. Novel complexes of a macrocyclic binucleating ligand By reaction of 5-methylisophthalaldehyde with 1,3-diaminopropane in the presence of various metal salts the following complexes have been isolated: MCu2Cl2,6H2O, MCu2(ClO4)2,2H2O, MCu2(HSO4)2,H2O, MNi...

(3/3) This concept of organising metal centers in tailored molecular architectures ultimately evolved into the field we know today as MOFs, earning the 2025 Nobel Prize in Chemistry!

You can read the foundational paper here: www.publish.csiro.au/CH/CH9702225

#AusJChem #MOFs

(2/3) The paper describes macrocyclic tetrakis-Schiff base ligands that can hold two metal cations in organised cavities, creating approximately square-pyramidal environments for Cu, Ni, Co, Fe, Mn, and Zn.

(1/3) This 1970 paper showcases the early brilliance of Richard Robson's work on macrocyclic binucleating ligands - foundational research contributing to the revolution in coordination chemistry and materials design.

A concise one-pot synthesis of flavones by cyclisation of o-(alkynon-1-yl)phenols A concise one-pot process for producing flavones and 2-alkyl-4H-benzopyran-4-one from a variety of salicylic acylbenzotriazoles is described. The in situ generation of o-(alkynon-1-yl)phenols in the i...

Khalid Widyan presents a novel one-pot synthesis of flavones and 2-alkyl-4H-benzopyran-4-one. He utilizes the ionic liquid [BMIM][BF₄] to provides a favourable reaction medium which increases the selectivity and yield of the syntheses

#AudJChem

Details: www.publish.csiro.au/CH/CH25044

Congratulations to our very own Prof Richard Robson (University of Melbourne & Florey Institute), along with Susumu Kitagawa (Kyoto University) and Omar M Yaghi ( University of California), on receiving the 2025 Nobel Prize in Chemistry for pioneering MOFs, a landmark in materials science! 👏

A proud moment for Australian science!

We were honoured to celebrate Prof Robson’s remarkable achievements in our 2019 Special Collection, and are thrilled to see him now recognised with the 2025 Nobel Prize in Chemistry! #AustJChem

Which you can revisit here:
www.publish.csiro.au/CH/issue/9431

Chemical Nature of Spent Coffee Grounds and Husks Waste coffee husks and spent coffee grounds (SCGs) are produced in large qualities worldwide. Characterisation of these waste streams from Australian commercial outlets in terms of lipid, caffeine, an...

☕ Happy International Coffee Day! ☕
Cosy up with your morning brew and check out this paper by Patti and colleagues reporting the lipid, caffeine, and polyphenol content of waste coffee husks and spent coffee grounds (SCGs) from Australian commercial outlets.
#AusJChem
More: doi.org/10.1071/CH20189

A recent review by Li et al. on cobalt oxide (Co₃O₄)-based catalysts as cost-effective alternatives for the oxygen evolution reaction in acidic media, vital for proton exchange membrane water electrolysis and green hydrogen production. #AusJChem #openaccess

www.publish.csiro.au/ch/pdf/CH25104

Liver microsome stability of N-methylated cyclic hexapeptides is decreased by the presence of cis-amide bonds N-methylation of cyclic peptides is a widely used strategy to enhance membrane permeability; however, it can also influence metabolic stability. In celebration of Professor David Craik’s scientific ac...

Hot off the press!
Hill et al. show that cis-amide conformations, not N-methylation alone, drive metabolic instability in cyclic hexapeptides.
Balance conformation and stability needed when optimising scaffolds for drug development.
#AusJChem #openaccess

www.publish.csiro.au/CH/CH25080

A red-emission fluorescent probe for monitoring polarity changes during ER stress induced by DTT The endoplasmic reticulum (ER) is the most extensive organelle within eukaryotic cells and functions as a critical hub for cellular biosynthesis. It plays a pivotal role in protein biosynthesis and li...

Hui Wang et al. report the construction of a series of red-emission compounds, offering an effective method for monitoring endoplasmic reticulum (ER) polarity changes and providing a novel approach for investigating diseases associated with abnormal ER polarity.
More: www.publish.csiro.au/CH/CH25035

Electrophilic fragment screening using native mass spectrometry to identify covalent probes for surface cysteines Covalent chemical probes form a covalent bond with a target protein of interest to elicit an effect and methods to identify and characterise them are needed. We developed a native mass spectrometry (n...

Poulsen et al. used native mass spectrometry to screen covalent fragments and found novel binders for surface cysteines in carbonic anhydrase III. Selective hits at Cys187 open new paths for probes & covalent drug discovery!
#openaccess @csiropublishing.bsky.social
www.publish.csiro.au/CH/CH25081

Preparation of dibenzimidazolium fluorescence probe based on binaphthol and the detection of Al3+ A dibenzimidazolium salt based on binaphthol, 2,2′-bis[2′-(1-ethylbenzimidazole)ethoxy]-1,1′-binaphthol hexafluorophosphate (1) was synthesised. The recognition of compound (1) for Al3+ was studied by...

Liu and coworkers report the synthesis of a dibenzimidazolium salt based on binaphthol, which demonstrates a strong binding affinity for Al3+. The compound proved useful as as a fluorescence probe that effectively distinguishes Al3+ from other cations. #AusJChem
More: www.publish.csiro.au/CH/CH25034

Specific Recognition of Methanol Using a Symmetric Tetramethylcucurbit[6]uril-Based Porous Supramolecular Assembly Incorporating Adsorbed Dyes A symmetric tetramethylcucurbit[6]uril-based porous supramolecular assembly was prepared in an aqueous H2SO4 solution (5 M). The driving force for the formation of this assembly is mainly the outer su...

Fei Yang Tian & Co. present their synthesis of a tetramethylcucurbit[6]uril-based porous supramolecular assembly that exhibits the characteristics of fluorophores it adsorbs and, which, in the presence of rhodamine B or pyrene, can detect methanol.

Details: www.publish.csiro.au/CH/CH19586

Effective enhancement of CO2 capture performance of solid amine adsorbents prepared from diethylenetriamine-modified mesoporous silica: optimisation experiments and kinetic calculations In this study, four DETA-SiO2 solid amine adsorbents were prepared by an impregnation method using diethylenetriamine (DETA) as the amine source and four types of silica with different pore structures...

Huipeng Zhao & al. present their optimization of CO2 with diethylenetriamine impregnated silica absorbents. They investigated the type of silica used, the concentration amine as well as the temperature and pressure of the CO2.

#AusJChem

Details: www.publish.csiro.au/CH/CH25056

Kelso et al. studied Aussie e-cigarettes using GC–MS and found unlabelled nicotine and banned toxins like cinnamaldehyde. Most were mislabelled, revealing major gaps in vaping regulation despite new reforms. #AusJChem #openaccess
@csiropublishing.bsky.social

www.publish.csiro.au/ch/pdf/CH25027

An unusual triterpene fatty acid conjugate from Dodonaea caespitosa An unusual triterpene fatty acid conjugate was isolated from the leaf resin of Dodonaea caespitosa. Its structure was formulated through spectroscopic analysis of the acetylated natural product and it...

Payne and coworkers @curtinuniversity.bsky.social report an unusual triterpene fatty acid conjugate, isolated from the leaf resin of Dodonaea caespitosa. This discovery will help the understanding of the biology and ecology of this plant. #AusJChem ‪

Details: doi.org/10.1071/CH25050

The development of a bioassay expressing the human MRGPRX2 receptor for ex vivo drug discovery Successful discovery of potent and selective ligands for therapeutically relevant receptors is indispensable for future clinical applications to treat a wide array of diseases. The mas-related G prote...

Tytgat et al. demonstrate a cost-effective bioassay to study the human MRGPRX2 receptor using frog oocytes. This technique enables the discovery of new allergy and immune disease treatments. #AusJChem #openaccess @csiropublishing.bsky.social

www.publish.csiro.au/CH/fulltext/...

Investigation of CO2 Adsorption on Triethylenetetramine Modified Adsorbents of TETA(n)/Zr-TSCD In the present study, a new type of material of Zr-TSCD was first synthesized and modified with different amounts of triethylenetetramine (TETA). The properties of the adsorbents were characterised wi...

Fan-Ming Yang & Co. Present a new type of Zr-TSCD (TSCD=Na3C6H5O72*H2O) material which, when functionalized with triethylenetetramine, displays enhanced CO2 adsorption, achieving stable selective adsorption rates as high as 175.1mg/g.

#AudJChem

Details: www.publish.csiro.au/CH/CH19541

Friedel–Crafts chemistry. Part 64. Facile syntheses of fused azepinoindoles by Jourdan–Ullmann and Friedel–Crafts approaches Facile and concise procedures for the construction of indole fused N-heterocyclic systems were described. A series of benzo-, pyrido-, thieno-, naphtho-fused azepinoindolones and indolo-azepinoquinoli...

El-Aal et al. reported efficient synthesis of indole-fused N-heterocycles via Jourdan–Ullmann and Friedel–Crafts approaches, yielding scaffolds with potential pharmacological value for medicinal chemistry applications. #AusJChem @csiropublishing.bsky.social

www.publish.csiro.au/CH/CH25003

Identification of the Cat Attractants Isodihydronepetalactone and Isoiridomyrmecin from Acalypha indica* Acalypha indica is a herb that grows throughout the tropical regions of the world. As well as being exploited for medicinal use, the roots of this plant are known to elicit a drug-like effect in cats. Recent research into feral cat control on Christmas Island has investigated whether a preparation of the roots of A. indica might be effective in traps to attract feral cats. However, the volatile nature of the attractants made it unviable for use in traps for more than a few days. In this study, we investigated the volatile components emitted by the plant roots and identified two iridoid compounds, (4R,4aR,7S,7aR)-isodihydronepetalactone and (4R,4aS,7S,7aR)-isoiridomyrmecin, which are known to affect behavioural activity in cats. Synthesis of standards confirmed the stereochemistry of both compounds emitted by the plant. Potential application of these compounds in feral cat control is discussed.

Happy international cat day!
This article by Gavin Flematti and coworkers identifies the cat attractants, Isodihydronepetalactone and Isoiridomyrmecin from the herb, acalypha indica. Potential application of these compounds in feral cat control is discussed. #AusJChem
Detail: doi.org/10.1071/CH15476

The value of telling it like it was. The best honours project ever? We use the example of textbook treatments of the ‘Rutherford nucleus’ to illustrate the need to avoid conflating important concepts, the ‘brick in the wall’ path to scientific understanding, the value...

Barnett et al. revisit the history of the “Rutherford nucleus” showing how scientific understanding evolves, highlighting the value of curiosity and telling science as it truly unfolded. #AusJChem #openaccess @csiropublishing.bsky.social
www.publish.csiro.au/CH/CH25070

Nicotinamide-Appended Fluorophores as Fluorescent Redox Sensors Fluorescent sensors have proved invaluable in elucidating the regulation and dysregulation of redox processes in biology, but understanding of the breadth of biological redox reactions requires develo...

Kathryn G. Leslie & al. explore the application of nicotinamide as a redox switch in conjunction with different amino fluorophores. They analyse four conjugates which are irreversibly sensitive to redox change, showing a shift in fluorescence.

#AusJChem

Details: www.publish.csiro.au/CH/CH19398

Rational design and selection of next-generation cyclotide drugs using the knotted cyclic peptide scaffold MCoTI-II Naturally occurring cyclic peptides have emerged as intriguing and relevant scaffolds for next-generation drug design. Especially peptides from the highly constrained cyclotide family provide an excep...

Hiroaki Suga and colleagues highlight tactics to engineer MCoTI-II, a cyclic cystine-knot peptide natural product, into next-generation therapeutics and diagnostics. These include rational design, loop grafting and genetically encoded discovery platforms. #AusJChem

www.publish.csiro.au/CH/CH25086

Nanomaterials at Interfaces between Immiscible Electrolyte Solutions The liquid–liquid interface between two immiscible electrolyte solutions (ITIES) offers a unique platform for the formation of nanomaterials, which exhibit redox electrocatalytic activities and enhanc...

Ji Zhao & Co. review the methods of nanoparticle formation at the interface between two immiscible electrolyte solutions (ITIES). The applications of these nanoparticles in electrocatalysis and electroanalysis are also explored.

#AusJChem

Details: www.publish.csiro.au/CH/CH19532

The cooperative effect of CPC micelles and RuIII on the rate enhancement of L-tyrosine oxidation by N-bromosuccinimide The impact of cetylpyridinium chloride (CPC) micelles on RuIII-catalysed oxidation kinetics of L-Tyrosine (L-Tyr) by N-bromosuccinimide (NBS) has been investigated in aqueous medium. The reaction’s pr...

Srivastava et al. investigate the impact of cetylpyridinium chloride (CPC) micelles on Ru(III)-catalysed oxidation kinetics of L-Tyrosine by N-bromosuccinimide in aqueous medium, elucidating the apparent catalytic influence of CPC micellar environments. #AusJChem

www.publish.csiro.au/CH/CH25030

Simultaneous conformity and non-conformity to Hammett’s linear free energy relationship (LFER): a rarity Linear free energy relationships (LFERs) are an important topic in physical-organic chemistry. When one browses the literature, one encounters innumerable instances wherein the series in question conf...

Skelton and colleagues report simultaneous conformity and non-conformity of Hammett’s linear free energy relationships in the same system, para-substituted phenyl pentazoles. This rarity and a plausible reason are discussed. #AusJChem @csiropublishing.bsky.social

www.publish.csiro.au/CH/CH24110

Air and Moisture Tolerant Synthesis of a Chelated bis(NHC) Methylpalladium(ii) Complex Relevant to Alkyl Migration Processes in Catalysis An air- and moisture-tolerant alternate synthetic pathway to the preparation of a cationic chelated bis(NHC) methylpalladium(ii) complex, [{(MesIm)2CH2}Pd(Me)(NCMe)][PF6], is described. The pathway in...

In this paper Michael G. Gardiner & Co. present a novel air and moisture tolerant synthesis for a cationic chelated bis(NHC) methyl Pd(II) complex. This method circumvents a previously reported unstable intermediate leading to a higher yield.

#AusJChem

Details: www.publish.csiro.au/CH/CH20194

A Facile Microwave and SnCl2 Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones An elegantly simple, facile, and robust approach to a scaffold of biological importance, 2,3-dihydroquinazolin-4(1H)-ones, is reported. A catalytic 1 % SnCl2/microwave-mediated approach afforded acces...

Nicholas S. O’Brien and Adam McCluskey present a facile catalytic microwave modulated method for 2,3-dihydroquinazolin-4(1H)-ones synthesis. The paper also investigates analogues of this scaffold, synthesising 41 species with 17-99% yields.

#AusJChem

Details: www.publish.csiro.au/CH/CH20101

Editor-in-Chief of the Australian Journal of Chemistry, George Koutsantonis, attended #OZOM15 and #OZRE25. His engagement with the community and insightful discussion about the journal’s direction and opportunities for authors was highly appreciated. #AusjChem @csiropublishing.bsky.social