Mathias Senge

Opportunity in chemical development at AstraZeneca (Dublin Ireland) closing: 27-Jan-2026 #SynChem #EUChemJobs #ChemJobs #chemsky 🧪
astrazeneca.eightfold.ai/careers/job/...

Metalation of Tetrakis(ethynylphenyl)porphyrin Films Grafted onto Glassy Carbon and Indium Tin Oxide Surfaces Thin films of a free-base porphyrin were grafted onto glassy carbon (gc) or indium tin oxide (ITO) electrodes by anodic deposition of 5,10,15,20-tetrakis(ethynylphenyl)porphyrin, H2TEPP. Metalation of...

Just out in #ACSElectrochem pubs.acs.org/doi/10.1021/... Starting the new year with some #porphyrin #electrochemistry 😉. Great collaboration @TCD_Chemistry @trinityresearch.bsky.social with #BillGeiger @uvmvermont.bsky.social #chemsky. 💶 @researchireland.ie

Bicyclo[1.1.1]pentane Ketones via Friedel–Crafts Acylation Bicyclo[1.1.1]pentane (BCP) is a rigid aliphatic hydrocarbon with a three-dimensional (3D), propeller-like shape and a molecular size that makes it a targeted bioisosteric replacement for phenylene an...

Just in time for under the Christmas tree🎄our paper on Friedel-Crafts acylation of bicyclo[1.1.1]pentane ketones out in @JOC_OL pubs.acs.org/doi/10.1021/.... Great work by Karolina and Freya; collaboration with #PavelMykhailiuk @EnamineLtd. Funded by @researchireland.ie @tum.de ‪@ias-tum.bsky.social

Controlling Rotational Motion of Nonplanar Porphyrin Atropisomers by Metal Coordination The unpredictable rotational barriers of nonplanar porphyrin atropisomers can be combated using metal coordination to form porphyrin superstructures, selectively capturing a single atropisomer from a...

new paper out in @helvchimacta.bsky.social
😊 Great work by #SophieAMaguire 👏
on how to control #atropisomerism in #porphyrins onlinelibrary.wiley.com/doi/10.1002/... collaboration @tcddublin.bsky.social @ias-tum.bsky.social
supported by @researchireland.ie @tum.de

I can't let the week pass without sharing that last week we had privileged to host the outstanding both @mathiassenge.bsky.social & @gracegdhan.bsky.social 🌟 Wonderful to welcome them to lovely Marburg and hear their science firsthand. #ProfLife - Thanks for visiting us at Marburg University

Porphyrin atropisomerism is an outstanding tool for the accessibility of shape specific molecules, yet over twenty years after the unusual rotational barriers of nonplanar porphyrins was observed, a quantitative relationship remains at large. There is a growing need to control this phenomenon in nonplanar porphyrin systems due to the mounting interest in these systems as enzyme-mimics and organocatalysts. Hence, in this work the influence of steric bulk on the stability of nonplanar 5,10,15,20-tetraaryl-2,3,7,8,12,13,17,18-octaethyl-porphyrin atropisomers was explored. The library of atropisomeric porphyrins synthesized herein emphasizes the delicate balance that must be achieved between steric bulk without inducing an undesired amount of macrocycle flexibility to obtain an atropisomer with a predictable rotational barrier. To overcome this challenge, a stabilization strategy was devised by exploiting metal coordination to the peripheral porphyrin functionalities, leading to an atroposelective superstructure formation.

new preprint out in @chemrxiv.org on how fixate #porphyrin #atropisomers via metal coordination chemrxiv.org/engage/chemr...
work at @ias-tum.bsky.social @tcddublin.bsky.social and supported by @tum.de @researchireland.ie stay tuned 😉

Quasicubanes versus Cubanes: Innovative Synthetic Organic Chemistry at University of Bath on FindAPhD.com PhD Project - Quasicubanes versus Cubanes: Innovative Synthetic Organic Chemistry at University of Bath, listed on FindAPhD.com

📢 TWO fully-funded 4-year PhD studentships (UK/home students only) available at University of Bath (Sept 2026 start), developing ambitious synthetic routes to novel caged molecules. Informal enquiries welcome (email scc98@bath.ac.uk), and for more info: www.findaphd.com/phds/project...

📣 Call for Applications 📣

Are you an international researcher eager to collaborate long-term with a TUM group? Our Fellowship programs offer multi-year opportunities to deepen scientific exchange and build lasting partnerships.

More information on individual programs below. Please share!

New researchers in the group @TCD_Chemistry 😀@esnireland.bsky.social #Erasmus students #SimonSackmaier @kit.edu 🇩🇪 and #MiaRescher @unimainz.bsky.social 🇩🇪 and further education student #ClodaghButtimer from @DIFEedu 🇮🇪 ⚗️🧪

Many congratulations to #FabioSantanni
our #MSCA @mariescurie-ire.bsky.social
fellow for the award "Premio Città di Firenze" 🏆for his PhD thesis: "Molecular Approaches for Quantum Technologies" with #RobertaSessoli @UNI_FIRENZE 😀🎉🥳

Oh, that is so great and well deserved :-). Congratulations Guillermo!!!! 👏🥳

(EPSRC CASE) Elevating Matched Molecular Pair Analysis with AI at The University of Manchester on FindAPhD.com PhD Project - (EPSRC CASE) Elevating Matched Molecular Pair Analysis with AI at The University of Manchester, listed on FindAPhD.com

🚀 Exciting PhD in Manchester!

Work with Andrew Leach, Lia Sotorrios & me, plus a placement at MedChemica Ltd. Combine computational chemistry, AI & drug design to explore how generative AI can accelerate new medicine discovery.

#CompChem #PhDStudentship

📩 www.findaphd.com/phds/project...

View of a research campus with grey concrete floor tiles and bright red fall foliage.

Fall foliage

This could be the view from your office if you come to visit!
The next call for Fellowship nominations is opening soon.

#VisitingProfessorships
#Sabbatical
#FallFoliage
#LeafPeeping
#NoFilter

Synthesis and Optical Properties of Unsymmetric Aromatically π-Extended BODIPY (@pubs.acs.org): pubs.acs.org/doi/full/10.... (@mathiassenge.bsky.social).

This Friday is #EuropeanResearchersNight ⚗️🧪Come visit us and other research groups @TCD_Chemistry
in @tcdTBSI @TCD_Chemistry @tcddublin.bsky.social . Everyone is welcome 📢! Great science and fun people 👨‍🔬👩‍🔬😀#porphyrins #chlorophyll #cubane #BODIPY #PDT #bicyclopentane @researchireland.ie

A series of unsymmetrically substituted BODIPY dyes featuring fused benzo- or naphtho-fragments on one pyrrolic unit were synthesized from the corresponding pyrrolic precursors. The synthetic route was optimized using a modular approach based on the condensation of formylpyrroles with alkylpyrroles, enabling the identification of precursor combinations that minimize byproduct formation and improve preparative yields. The resulting benzo- and naphtho-fused BODIPYs display intense fluorescence in the red region, with emission maxima spanning 590–680 nm and fluorescence quantum yields ranging from 0.27 to 0.84. Their two-photon absorption (2PA) properties were studied both experimentally and computationally. An increase in the two-photon absorption cross-section with an increase in the size of the π-conjugated system was observed, reaching 80 GM for the naphthoBODIPY derivative. These findings demonstrate the potential of π-extended BODIPY scaffolds as NIR-active fluorophores with enhanced nonlinear optical properties.

Out in @JOC_OL
#JOC: Synthesis and Optical Properties of Unsymmetric Aromatically π-Extended #BODIPY. Great collaboration with #MikhailFilatov @TUDubChemBPharm
@TCD_Chemistry
😀 pubs.acs.org/doi/full/10.... plus #sciart cover picture 🎨. Funded by @researchireland.ie

And for anyone who is interested in Theodor Förster's life and career before, during, and after National Socialism in Germany, we recently published this Viewpoint article in Angewandte Chemie - onlinelibrary.wiley.com/doi/10.1002/...

New semester @tcddublin.bsky.social means the next generation of scientists starting out in research. Here are Kimberley, Susan, and Anna-Sophia 🇮🇪🇮🇪🇩🇪 from @TCD_Chemistry joining us for their #capstone research project ⚗️Lot's of #porphyrin, #cubane, and #bicyclopentane molecules to come😃

Just before the start of term @tcddublin.bsky.social Karolina, Liam and Sophie escaped to Berlin 🇩🇪 to attend the #TPDG #tetrapyrrole discussion group meeting @humboldtuni.bsky.social 😀 As always a great small meeting!

Die Bewerbungsphase für das GDCh-Mentoringprogramm CheMento ist gestartet! Suchst du Orientierung für deinen Karriereweg in der Chemiebranche? 🔬 Oder möchtest du als Mentor:in dein Wissen und deine Erfahrungen weitergeben? 🤝 Dann ist CheMento die ideale Gelegenheit für dich:
www.gdch.de/mentoring

Six ERC Starting Grants for researchers at TUM Six further researchers at TUM are to receive the prestigious ERC Starting Grants for their projects.

Congratulations to six of our #researchers, including Lukas Heinrich, who receive prestigious ERC #StartingGrants worth up to 1.5 million euros each for projects in #informatics, #medicine, #LifeSciences & #NaturalSciences: go.tum.de/682017 👏

#ERCStG @erc.europa.eu

📷A.Eckert

The last #WednesdayCoffeeTalk of this summer semester: Florian Egli @tum.de on "The challenge of creating value for all in the global transition towards sustainability".

Part of the IAS Seminar Series of European Universities on Sustainability! DM us for more info.

www.ias.tum.de/ias/news-eve...

It's summer time 🌤️and that always means research interns: here are Joe, Syed, and Susan 😀. All are locals from our School @tcddublin.bsky.social, Syed is a @rsc.org
#RISE student and Susan has a @rsc.org
#UGResearchBursary 😀

Bicyclo[1.1.1]pentane is a rigid aliphatic hydrocarbon with a three-dimensional (3D), propeller-like shape and a molecular size which makes it a targeted bioisosteric replacement for phenylene and acetylene groups in medicinal chemistry. For the pharmaceutical application of BCP, simple, efficient, and cost-effective synthetic tools are required to enable the exploration of BCP’s potential as a bioisostere across a broad chemical space. The synthesis of BCP mono- and diketones remains a challenging task, limited by both substrate scope and expensive photocatalysts. Here we present a protocol for Friedel-Crafts acylation of (hetero)aromatic hydrocarbons with BCP acyl chlorides; in particular, the first method to access diaromatic BCP 1,3-diketones. Reaction optimization, substrate scope, and reactivity of the products are discussed. 35 mono- and diketones are reported accompanied by 7 examples of post-synthetic modifications. The synthesis of a BCP analogue of fenofibrate is reported.

Check out our new #preprint 📢😀"Bicyclo[1.1.1]pentane Ketones via Friedel-Crafts Acylation" #BCP #isostere @chemrxiv.bsky.social
chemrxiv.org/engage/chemr... great work by Freya and Karolina and coop with #PavelMykhailiuk #EnamineLtd
🇺🇦 supported by @researchireland.ie @ias-tum.bsky.social

While rest of us had group meeting in the rain🌧️ @tbsi-tcd.bsky.social @tcddublin.bsky.social in Dublin: Karolina, Sophie, and Liam are off into the sun 🌞in Salerno at the #SupraChemDays25 meeting showing off cool chemistry ⚗️on #porphyrins, #organocatalysis, #atropisomers, #bicyclopentane 😀

Congratulations to Marike et al. 👍👏

Happy birthday IAS 🎉🎈
A truly unique, supportive and stimulating institute. Best place I ever had the honor to be affiliated with!
And many thanks for the support and kind hospitality over the last few years!

Third speaker from the 2nd session on Day2 is delivered by Prof. Mathias O. Senge from @tcddublin @TCD_Chemistry #ECMolS2025

TUM to receive funding for seven Clusters of Excellence In future, seven Clusters of Excellence at TUM and its cooperation partners will be funded.

Our university receives funding by the
@dfg.de for four renewed and three newly approved #ClustersofExcellence!👏Research areas include #energy, #quantumtech, #health, and #societaltransformation. Congrats to all researchers involved! go.tum.de/844846 🎉

@wissenschaftsrat.de
📷 @prolehre.bsky.social

Many thanks 😀