Mathias Senge

Synthesis and Optical Properties of Unsymmetric Aromatically π-Extended BODIPY (@pubs.acs.org): pubs.acs.org/doi/full/10.... (@mathiassenge.bsky.social).

This Friday is #EuropeanResearchersNight ⚗️🧪Come visit us and other research groups @TCD_Chemistry
in @tcdTBSI @TCD_Chemistry @tcddublin.bsky.social . Everyone is welcome 📢! Great science and fun people 👨‍🔬👩‍🔬😀#porphyrins #chlorophyll #cubane #BODIPY #PDT #bicyclopentane @researchireland.ie

A series of unsymmetrically substituted BODIPY dyes featuring fused benzo- or naphtho-fragments on one pyrrolic unit were synthesized from the corresponding pyrrolic precursors. The synthetic route was optimized using a modular approach based on the condensation of formylpyrroles with alkylpyrroles, enabling the identification of precursor combinations that minimize byproduct formation and improve preparative yields. The resulting benzo- and naphtho-fused BODIPYs display intense fluorescence in the red region, with emission maxima spanning 590–680 nm and fluorescence quantum yields ranging from 0.27 to 0.84. Their two-photon absorption (2PA) properties were studied both experimentally and computationally. An increase in the two-photon absorption cross-section with an increase in the size of the π-conjugated system was observed, reaching 80 GM for the naphthoBODIPY derivative. These findings demonstrate the potential of π-extended BODIPY scaffolds as NIR-active fluorophores with enhanced nonlinear optical properties.

Out in @JOC_OL
#JOC: Synthesis and Optical Properties of Unsymmetric Aromatically π-Extended #BODIPY. Great collaboration with #MikhailFilatov @TUDubChemBPharm
@TCD_Chemistry
😀 pubs.acs.org/doi/full/10.... plus #sciart cover picture 🎨. Funded by @researchireland.ie

And for anyone who is interested in Theodor Förster's life and career before, during, and after National Socialism in Germany, we recently published this Viewpoint article in Angewandte Chemie - onlinelibrary.wiley.com/doi/10.1002/...

New semester @tcddublin.bsky.social means the next generation of scientists starting out in research. Here are Kimberley, Susan, and Anna-Sophia 🇮🇪🇮🇪🇩🇪 from @TCD_Chemistry joining us for their #capstone research project ⚗️Lot's of #porphyrin, #cubane, and #bicyclopentane molecules to come😃

Just before the start of term @tcddublin.bsky.social Karolina, Liam and Sophie escaped to Berlin 🇩🇪 to attend the #TPDG #tetrapyrrole discussion group meeting @humboldtuni.bsky.social 😀 As always a great small meeting!

Die Bewerbungsphase für das GDCh-Mentoringprogramm CheMento ist gestartet! Suchst du Orientierung für deinen Karriereweg in der Chemiebranche? 🔬 Oder möchtest du als Mentor:in dein Wissen und deine Erfahrungen weitergeben? 🤝 Dann ist CheMento die ideale Gelegenheit für dich:
www.gdch.de/mentoring

Six ERC Starting Grants for researchers at TUM Six further researchers at TUM are to receive the prestigious ERC Starting Grants for their projects.

Congratulations to six of our #researchers, including Lukas Heinrich, who receive prestigious ERC #StartingGrants worth up to 1.5 million euros each for projects in #informatics, #medicine, #LifeSciences & #NaturalSciences: go.tum.de/682017 👏

#ERCStG @erc.europa.eu

📷A.Eckert

The last #WednesdayCoffeeTalk of this summer semester: Florian Egli @tum.de on "The challenge of creating value for all in the global transition towards sustainability".

Part of the IAS Seminar Series of European Universities on Sustainability! DM us for more info.

www.ias.tum.de/ias/news-eve...

It's summer time 🌤️and that always means research interns: here are Joe, Syed, and Susan 😀. All are locals from our School @tcddublin.bsky.social, Syed is a @rsc.org
#RISE student and Susan has a @rsc.org
#UGResearchBursary 😀

Bicyclo[1.1.1]pentane is a rigid aliphatic hydrocarbon with a three-dimensional (3D), propeller-like shape and a molecular size which makes it a targeted bioisosteric replacement for phenylene and acetylene groups in medicinal chemistry. For the pharmaceutical application of BCP, simple, efficient, and cost-effective synthetic tools are required to enable the exploration of BCP’s potential as a bioisostere across a broad chemical space. The synthesis of BCP mono- and diketones remains a challenging task, limited by both substrate scope and expensive photocatalysts. Here we present a protocol for Friedel-Crafts acylation of (hetero)aromatic hydrocarbons with BCP acyl chlorides; in particular, the first method to access diaromatic BCP 1,3-diketones. Reaction optimization, substrate scope, and reactivity of the products are discussed. 35 mono- and diketones are reported accompanied by 7 examples of post-synthetic modifications. The synthesis of a BCP analogue of fenofibrate is reported.

Check out our new #preprint 📢😀"Bicyclo[1.1.1]pentane Ketones via Friedel-Crafts Acylation" #BCP #isostere @chemrxiv.bsky.social
chemrxiv.org/engage/chemr... great work by Freya and Karolina and coop with #PavelMykhailiuk #EnamineLtd
🇺🇦 supported by @researchireland.ie @ias-tum.bsky.social

While rest of us had group meeting in the rain🌧️ @tbsi-tcd.bsky.social @tcddublin.bsky.social in Dublin: Karolina, Sophie, and Liam are off into the sun 🌞in Salerno at the #SupraChemDays25 meeting showing off cool chemistry ⚗️on #porphyrins, #organocatalysis, #atropisomers, #bicyclopentane 😀

Congratulations to Marike et al. 👍👏

Happy birthday IAS 🎉🎈
A truly unique, supportive and stimulating institute. Best place I ever had the honor to be affiliated with!
And many thanks for the support and kind hospitality over the last few years!

Third speaker from the 2nd session on Day2 is delivered by Prof. Mathias O. Senge from @tcddublin @TCD_Chemistry #ECMolS2025

TUM to receive funding for seven Clusters of Excellence In future, seven Clusters of Excellence at TUM and its cooperation partners will be funded.

Our university receives funding by the
@dfg.de for four renewed and three newly approved #ClustersofExcellence!👏Research areas include #energy, #quantumtech, #health, and #societaltransformation. Congrats to all researchers involved! go.tum.de/844846 🎉

@wissenschaftsrat.de
📷 @prolehre.bsky.social

Many thanks 😀

Collaborative study with #TKoczorowski @pums-poznan.bsky.social 🇵🇱 #MAFilatov @TUDubChemBPharm
+our group @tcddublin.bsky.social 🇮🇪 on the spectroelectrochemistry of meso-aryl BODIPY out in #JMolStruct sciencedirect.com/science/arti... 😀#DyeSicPhoto @researchireland.bsky.social @tbsi-tcd.bsky.social

and at the same time Sophie, Liam, Freya and Karolina were busy at the @rsc.org #OrganicChemistryIreland meeting in Belfast 😀. #porphyrins #atropisomers #bicyclopentane #flowchemistry ⚗️ ... @researchireland.ie

Congratulations, nice 😀👏

Meeting old and new friends at the Bürgenstock conference #SCS_BC25 🇨🇭 @aklymchenko.bsky.social #DanielGryko @mathiassenge.bsky.social ShoubhikDas 😀. Great meeting and great science 🧪⚗️@swisschemistry.bsky.social

Scientists reel as turmoil roils National Science Foundation The National Science Foundation, a major government funder of basic science research, is being shaken up with over 1,000 grants already terminated and the White House looking to halve its budget

The National Science Foundation, a major government funder of basic science research, is being shaken up with over 1,000 grants already terminated and the White House looking to halve its budget.

Scientists reel as turmoil roils National Science Foundation The National Science Foundation, a major government funder of basic science research, is being shaken up with over 1,000 grants already terminated and the White House looking to halve its budget

www.npr.org/2025/05/02/n...

😁

Happy to welcome #JeanneIffrig who joins our group @tcddublin.bsky.social sky.social @tbsi-tcd.bsky.social
as an @euerasmusplus.bsky.social visiting researcher from @univ-amu.fr 🇫🇷 She is working on new types of #crownether containing sp3-rich rigid hydrocarbon units⚗️

This study demonstrates a visible-light-induced topochemical #cycloaddition of a bimane derivative. 
➡️ https://www.beilstein-journals.org/bjoc/articles/21/37?B=y 
#bimanes #cycloaddition #cyclobutanes. #fluorescence #BJOC 💎🔓
@mathiassenge.bsky.social

Nice group outing seeing the #bogskin exhibition 🖼️🎨@rha-arts.bsky.social and visiting with our artist friend #SiobhanMcDonal www.siobhanmcdonald.com
😀Great to see that #ArtScience is alive and flourishing!

Very happy to welcome #ChiaraBaldi from #RobertaSessoli's group U Firenze 🇮🇹 as a visiting #PhD student in @tcddublin.bsky.social😀. Chiara will work with us on the synthesis of paramagnetic #porphyrins for optical and #chirality-induced #spin polarization ⚗️@researchireland.bsky.social

Exploring cage bicyclic hydrocarbons as bioisosteres for novel fragrances
www.chemistryviews.org/exploring-ne...

Many thanks Jose!