Canadian Critical Care Trials Group (CCCTG)

Tomorrow: In recognition of her pioneering research in critical care medicine, Dr Deborah Cook will be inducted into the Canadian Medical Hall of Fame. Congratulations to the 2025 Laureates!

Details: www.cdnmedhall.ca/news/six-out... @cmadocs.bsky.social

INdex @ccctg.bsky.social @criticalcarereviews.com

From JAMA Neurology: CT perfusion and CT angiography showed less than optimal accuracy for confirming death by neurologic criteria.

#CCR25 @criticalcarereviews.com

ja.ma/3TeogPR

Happening now! INdex Study Results at #CCR25. Catch the livestream: criticalcarereviews.com

Lauralyn McIntyre & Monica Taljaard summarise the FLUID trial presented yesterday at the Critical Care Reviews Meeting 2025 and simultaneously published in the @nejm.org
www.nejm.org/doi/full/10....

INdex Trial Results, coming up at Critical Care Reviews in Belfast! Watch at 10:20AM Eastern for those tuning in from Canada. Free livestream: criticalcarereviews.com #CCR25

PROMIZING Trial Results presented at #CCR25 in Belfast. Congrats to Dr Karen Bosma and the PROMIZING team. See the full trial results in @nejm.org

PROMIZING RCT@ccctg.bsky.social @criticalcarereviews.com #CCR25

#PROMIZINGtrial results are in - no difference in time to successful liberation from mechanical ventilation between proportional-assist ventilation and pressure support ventilation
#CCR25

A graph showing the cumulative probability of successful liberation from ventilation and of death before successful liberation.

In the PROMIZING trial, proportional-assist ventilation with load-adjustable gain factors did not differ significantly from pressure-support ventilation with respect to the time to liberation from mechanical ventilation. Full trial results: nej.md/4kC2a67

@criticalcarereviews.com #CCR25

FLUID trial results are coming thick and fast!

📰 Use of Ringer’s lactate, when compared with normal saline, did not modify survival or hospital readmission within 90 days in a hospital-wide intervention!

The FLUID Trial Results were just presented at #CCR25 in Belfast. Congrats to the FLUID team! See the full trial results in @nejm.org: www.nejm.org/doi/full/10....

Forest plots of the subgroup analyses

Presented at #CCR25:

In a cluster-randomized, crossover trial, hospital-wide use of lactated Ringer’s solution as compared with normal saline did not alter the incidence of death or hospital readmission within 90 days. Full trial results: nej.md/45SaEBs

@criticalcarereviews.com

Also the trial was fully data enabled allowing outcomes to be collected via routine data making the data collection super efficient 3/3

Neat features including use of routine healthcare data to estimate the likely ICC and cluster autocorrelation coefficient which gave accurate estimates for the sample size calcs 2/3

A Crossover Trial of Hospital-Wide Lactated Ringer’s Solution versus Normal Saline | NEJM Whether lactated Ringer’s solution is clinically superior to normal saline for routine intravenous administration of fluids is uncertain. In an open-label, two-period, two-sequence, cross-sectional...

Another super cluster crossover trial at #CCR25 - the FLUID trial (looking at Ringers lactate vs normal saline - at the system level). 1/3 See paper here … www.nejm.org/doi/full/10....

#CCR25

⏰ Coming up at 10:30 ET: Don't miss FLUID Trial Results, live from #CCR2025 in Belfast!
Catch Dr Lauralyn McIntyre's presentation on the livestream criticalcarereviews.com

Now we have Prof Niall Ferguson from Toronto providing an editorial ... and he begins with some 18th century philosophy!

#CCR25

#CCR25 … here we go! Three days of deep discussion of the top trials in critical care. If you are not in the room, do connect via livestream - see criticalcarereviews.com

🚨 12 Major Critical Care Trials 🚨

🌟 Global experts
🗣️ Live discussion

📺 Join the free livestream of #CCR25 – where critical care meets cutting-edge evidence 💡

🌍 Streaming the latest trials & analysis you don't want to miss 📊🧪

🔗 https://criticalcarereviews.com/meetings/ccr25

Thank you to all speakers at Spring Canadian Critical Care Translational Biology Group (CCCTBG) meeting in Magog, QC! 🇨🇦 Inspiring talks on microvascular monitoring in shock, immune responses in critical illness, preclinical models, endothelial protection in shock, and neuroprotection post-stroke 👏

Deadline extension: Apply by May 26! 👇

LifTING & Sepsis Canada Health Research Training Platform We are a fully-funded, two-year virtual training program dedicated to advancing health research in life-threatening illnesses and sepsis.

Are you passionate about health research? Our colleagues at the LifTING Health Research Training Program have opened applications for their 2025-2027 virtual cohort. Check out the ✨NEW✨ LifTING website for details:

liftingsepsiscanada-hrtp.ca/home

Opinion: Without integrating our health data, Canada risks being left behind By engaging in public-private partnerships, other countries are pulling ahead in having faster and better access to cutting-edge treatments

"In combining data with scientific excellence, Canada can emerge as the best jurisdiction globally for health care innovation."
www.theglobeandmail.com/opinion/arti...

🚨 Save the Date! 🚨

🌍 In 38 days, we celebrate the #PedsICU community worldwide!

📢 WFPICCS announces the World PICU Awareness Week 2025 focusing on the theme "Technology and Innovation in PICU"

Learn more here: wfpiccs.org/2025-world-p...

Stay tuned!

#WPAW25 #WFPICCS

The New England Journal of Medicine Antibiotic Treatment for 7 or 14 Days for Bloodstream Infection A Research Summary based on The BALANCE Investigators | 10.1056/NEJMoa2404991 | Published on November 20, 2024 Visual representations of the patients in the trial and the treatments they were assigned. Read the full Research Summary at NEJM.org.

In the BALANCE trial, patients with bacteremia were assigned to 7 or 14 days of appropriate antimicrobial therapy, and 7 days of therapy was found to be noninferior to 14 days. Full trial results and Research Summary: nej.md/3Z5bTJD

#MedSky #CriticalCare #IDSky

CCCTG congratulations to our Vice Chair for this much-deserved honour! 🎉

Impact Story: Tapping the research potential of community hospitals | News At large university hospitals across Canada, clinical trials are underway for everything from better disease detection, to improving existing treatments, to evaluating groundbreaking new therapies. Ho...

Impact Story: Tapping the research potential of community hospitals www.ccctg.ca/news-events/...

For more information about this ongoing work, please don't hesitate to get in touch!