Canadian Critical Care Trials Group (CCCTG)

We're inspired by the extraordinary dedication of the CCCTG's immediate Past Chair, Rob Fowler. Heartfelt congratulations to Rob! 👏

50-cent drug could save hospitals thousands of dollars The drug is predicted to have the potential to save some $4,950 per patient on average, according to a new study.

NEW! Health economic evaluation of the REVISE trial: 50-Cent Drug Could Save Hospitals Thousands of Dollars www.newsweek.com/50-cent-drug...

📅 Tuesday at #CCCF! Late-breaking study - CANCOV: Canadian Multi-Centre Cohort Study of 3-Year Outcomes after COVID Critical Illness. Program details: criticalcarecanada.com/program-final/ #CCCF2025

Using antibiotics early on in intensive care prevents infection A Sunnybrook-led study – the world’s largest and longest clinical trial in critical care – has shown a significant reduction in hospital-acquired infection in critically-ill patients on mechanical…

Read the story from @sunnybrookhsc.bsky.social Research Institute: research.sunnybrook.ca/2025/10/usin...

The world’s largest and longest clinical trial in critical care, SuDDICU found a significant reduction in hospital-acquired infection in critically ill patients on mechanical ventilation, when given antibiotics preventatively before a new infection can develop.

Selective Decontamination of the Digestive Tract during Ventilation in the ICU | NEJM Whether selective decontamination of the digestive tract (SDD) reduces mortality among patients undergoing mechanical ventilation and whether it adversely affects microbial ecology in the intensive...

New in @NEJM: CCCTG and @anzics.bsky.social have published the SuDDICU study www.nejm.org/doi/full/10....

European Society of Intensive Care Medicine Original Article | Oct 29, 2025 | NEJM.org Selective Decontamination of the Digestive Tract during Ventilation in the ICU Figure 2. Subgroup Analysis of In-Hospital Death at 90 Days.

In the SuDDICU trial of patients undergoing mechanical ventilation in the intensive care unit, selective decontamination of the digestive tract did not result in a lower incidence of in-hospital death than standard care alone. Full trial results: nej.md/4nhyeN8

#LIVES2025 | @esicm.bsky.social

Core elements of consent documentation for clinical research in Canada: guidance for policy Background: Consent forms have become too long and often do little to help people understand the risk elements of their participation in research, instead focusing on risk reduction for research insti...

Consent documentation for clinical research guideline:
A core set of elements for participant consent documents to be used in clinical research across Canada.
➡️ www.cmaj.ca/lookup/doi/10.1503/cmaj.250500

Core elements of consent documentation for clinical research in Canada: guidance for policy Background: Consent forms have become too long and often do little to help people understand the risk elements of their participation in research, instead focusing on risk reduction for research insti...

📣 The CCCTG and CIHR’s Ethics Office created a guideline for a simplified template for informed consent - published TODAY in ‪@cmaj.ca‬

See the full guideline: www.cmaj.ca/lookup/doi/1...

Tomorrow: In recognition of her pioneering research in critical care medicine, Dr Deborah Cook will be inducted into the Canadian Medical Hall of Fame. Congratulations to the 2025 Laureates!

Details: www.cdnmedhall.ca/news/six-out... @cmadocs.bsky.social

INdex @ccctg.bsky.social @criticalcarereviews.com

From JAMA Neurology: CT perfusion and CT angiography showed less than optimal accuracy for confirming death by neurologic criteria.

#CCR25 @criticalcarereviews.com

ja.ma/3TeogPR

Happening now! INdex Study Results at #CCR25. Catch the livestream: criticalcarereviews.com

Lauralyn McIntyre & Monica Taljaard summarise the FLUID trial presented yesterday at the Critical Care Reviews Meeting 2025 and simultaneously published in the @nejm.org
www.nejm.org/doi/full/10....

INdex Trial Results, coming up at Critical Care Reviews in Belfast! Watch at 10:20AM Eastern for those tuning in from Canada. Free livestream: criticalcarereviews.com #CCR25

PROMIZING Trial Results presented at #CCR25 in Belfast. Congrats to Dr Karen Bosma and the PROMIZING team. See the full trial results in @nejm.org

PROMIZING RCT@ccctg.bsky.social @criticalcarereviews.com #CCR25

#PROMIZINGtrial results are in - no difference in time to successful liberation from mechanical ventilation between proportional-assist ventilation and pressure support ventilation
#CCR25

A graph showing the cumulative probability of successful liberation from ventilation and of death before successful liberation.

In the PROMIZING trial, proportional-assist ventilation with load-adjustable gain factors did not differ significantly from pressure-support ventilation with respect to the time to liberation from mechanical ventilation. Full trial results: nej.md/4kC2a67

@criticalcarereviews.com #CCR25

FLUID trial results are coming thick and fast!

📰 Use of Ringer’s lactate, when compared with normal saline, did not modify survival or hospital readmission within 90 days in a hospital-wide intervention!

The FLUID Trial Results were just presented at #CCR25 in Belfast. Congrats to the FLUID team! See the full trial results in @nejm.org: www.nejm.org/doi/full/10....

Forest plots of the subgroup analyses

Presented at #CCR25:

In a cluster-randomized, crossover trial, hospital-wide use of lactated Ringer’s solution as compared with normal saline did not alter the incidence of death or hospital readmission within 90 days. Full trial results: nej.md/45SaEBs

@criticalcarereviews.com

Also the trial was fully data enabled allowing outcomes to be collected via routine data making the data collection super efficient 3/3

Neat features including use of routine healthcare data to estimate the likely ICC and cluster autocorrelation coefficient which gave accurate estimates for the sample size calcs 2/3

A Crossover Trial of Hospital-Wide Lactated Ringer’s Solution versus Normal Saline | NEJM Whether lactated Ringer’s solution is clinically superior to normal saline for routine intravenous administration of fluids is uncertain. In an open-label, two-period, two-sequence, cross-sectional...

Another super cluster crossover trial at #CCR25 - the FLUID trial (looking at Ringers lactate vs normal saline - at the system level). 1/3 See paper here … www.nejm.org/doi/full/10....

#CCR25

⏰ Coming up at 10:30 ET: Don't miss FLUID Trial Results, live from #CCR2025 in Belfast!
Catch Dr Lauralyn McIntyre's presentation on the livestream criticalcarereviews.com

Now we have Prof Niall Ferguson from Toronto providing an editorial ... and he begins with some 18th century philosophy!

#CCR25

#CCR25 … here we go! Three days of deep discussion of the top trials in critical care. If you are not in the room, do connect via livestream - see criticalcarereviews.com

🚨 12 Major Critical Care Trials 🚨

🌟 Global experts
🗣️ Live discussion

📺 Join the free livestream of #CCR25 – where critical care meets cutting-edge evidence 💡

🌍 Streaming the latest trials & analysis you don't want to miss 📊🧪

🔗 https://criticalcarereviews.com/meetings/ccr25