Thx for reminding @gromesroland.bsky.social freezer was „only“ +39C that Monday, yet it turned everything (🐁🐇🐟) into an undefined goo …. I learned a lot about humans that day: most came holding their noses, laughing and taking fotos of Colin & me in full protection cleaning out the mess. Nice. Not.

02.09.2025 12:07 — 👍 1    🔁 0    💬 1    📌 0

@cosheidelberg.bsky.social today

03.07.2025 16:24 — 👍 0    🔁 0    💬 0    📌 0

Proud of Kaisa Pakari @kpakari.bsky.social to receive the 2025 Schmeil young researcher award for her #PhD thesis. She established 🐟 models to address disorders of #glycosylation #CDG by advancing #baseediting range for precise genome editing @wittbrodtlab.bsky.social @cos.uni-heidelberg.de

03.07.2025 16:04 — 👍 9    🔁 3    💬 1    📌 0

it certainly is!

25.06.2025 05:53 — 👍 1    🔁 0    💬 0    📌 0

GfE School 2025

Are you in Germany in September (25th-27th) and ready to present your science? no further hesitation and register for the 15th GfE School on "Lineages: Revealing how Cells make Embryos and Tissues" at Schloss Reisensburg: www.vbio.de/gfe-entwickl... all #devbio enthusiasts and interested welcome!

24.06.2025 23:45 — 👍 31    🔁 17    💬 1    📌 1

LAST CHANCE TO REGISTER!

Calling all medaka researchers and enthusiasts!

Don't miss your chance to connect with the growing medaka community, share ideas, and spark new collaborations! The Medaka PI/ERC Indigene Meeting 2025 is just around the corner!

REGISTER NOW → meetmedaka.com

27.05.2025 08:07 — 👍 7    🔁 4    💬 0    📌 1

study performed with @kpakari.bsky.social, #medaka and @wittbrodtlab.bsky.social at @cosheidelberg.bsky.social

26.05.2025 08:22 — 👍 1    🔁 0    💬 0    📌 0

Establishing an auxin-inducible GFP nanobody-based acute protein knockdown system to mimic hypomorphic mutations during early medaka embryogenesis Creating hypomorphic mutations are crucial to study gene function in vivo, especially when null mutations result in (embryonic) lethality. This is especially the case for enzymes involved in glycosyla...

new #preprint: mRNA delivered degron system w/ GFP-nanobody to efficiently reduce GFP-tagged proteins in an inducible manner in 🐟 Case study: reduction of PMM2 (basis for ER-based #glycosylation) causes hypoglycosylation reported from CDG-patients www.biorxiv.org/content/10.1... #CRISPR #RareDisease

26.05.2025 08:22 — 👍 5    🔁 1    💬 2    📌 2

Happy to share our new preprint on lens morphogenesis in ocular organoids. All thanks to Elin Stahl, Miguel Angel Delgado-Toscano, Ishwariya Saravanan, Anastasija Paneva and Jochen Wittbrodt @wittbrodtlab.bsky.social

www.biorxiv.org/content/10.1...

23.04.2025 21:19 — 👍 18    🔁 9    💬 0    📌 1

Discovery and characterisation of gene by environment and epistatic genetic effects in a vertebrate model Phenotypic variation arises from the interplay between genetic and environmental factors. However, disentangling these interactions for complex traits remains challenging in observational cohorts such...

New pre-print klaxon: "Discovery and characterisation of gene by environment and epistatic genetic effects in a vertebrate model" led by the excellent Bettina Welz + @saulpierotti.bsky.social from @wittbrodtlab.bsky.social, Felix Loosli, Kiyoshi Naruse and my own lab www.biorxiv.org/content/10.1...

28.04.2025 15:17 — 👍 46    🔁 19    💬 2    📌 5

Register quickly and swim by! #medaka #meeting #conference

07.04.2025 13:39 — 👍 2    🔁 0    💬 0    📌 0