Nadine Hillock

Hardly any National Action Plans to address antimicrobial resistance include reducing antibiotic use as an explicit goal 🤯

Report shows only 3 countries had a significant reduction in sales after implementing their NAPs: Jordan, Sth Africa & Indonesia 👏👏
#AMR #NAP
doi.org/10.1017/ice....

‘Pharma companies make money on a new drug by selling a lot or charging a lot - but with antimicrobials neither is possible.’ - Andrew Bowskill #AAMRNet.
Delinking funding from use is the only way to stimulate investment in new antimicrobials #MTPConnect #AMR #antimicrobials @drewabow.bsky.social

Surveillance of antimicrobial use and resistance ‘in isolation is like counting raindrops in a thunderstorm’ - we need more investment in innovation and prevention of AMR. Dr Richard Alm
Speaking in Adelaide #MTPConnect #AAMRNet #AMR #PublicHealth #antimicrobials @carb-x.bsky.social

Incidence and prevalence of antimicrobial resistance in outpatients with cancer: a multicentre, retrospective, cohort study AMR proportions and IRRs for most key pathogens were up to three-times higher in isolates from outpatients with cancer than those without cancer, highlighting the need for enhanced surveillance, infec...

Study highlights higher risk of multidrug-resistant pathogens in cancer patients: analysis of US data compared cancer outpatient cohort with non-cancer patients.
eg. 2-3x higher incidence of carbopenem-resistant P.aeruginosa #AMR #AMS
www.thelancet.com/journals/lan...
‪@thelancetoncol.bsky.social‬

Spero Therapeutics and GSK Announce PIVOT-PO Phase 3 Study for Tebipenem HBr Stopped Early for Efficacy Following Review by Independent Data Monitoring Committee If approved, tebipenem HBr could be the first oral carbapenem antibiotic for US patients with complicated urinary tract infections (cUTIs) An estimated 2.9...

Tebipenem - a new oral carbapenem for complicated UTIs - efficacy data is good 😀

Marketing now the challenge - how to make it profitable for pharma but prevent overuse? 🤔

De-linked funding model needed!

#tebipenem #PIVOT-PO #antibiotic #de-linked #AMR #AMS

www.globenewswire.com/news-release...

Topical use of last-line antibiotics during surgery largely undocumented - potential focus for stewardship and improved governance. Australian surveillance data illustrates rifampicin use not uncommon.
doi.org/10.1017/ash....

To celebrate #IDPharmacistsDay look out for the videos from AdPha.au pharmacists showcasing their contributions to Innovations in Infectious Diseases @adphaau.bsky.social @nadinehillock.bsky.social @sonkoning.bsky.social @leggwamy.bsky.social @sidpharm.bsky.social

A global atlas and drivers of antimicrobial resistance in Salmonella during 1900-2023 - Nature Communications Salmonella is a major cause of foodborne disease worldwide. Authors created a Salmonella database and present a genetic atlas of antimicrobial resistance, identifying some socioeconomic and environmen...

Analysis of over 208K Salmonella genomes find that #AMR varies by region, source, and serovar, with increases linked to poultry and environment. Antibiotic use, agriculture, and climate drive AMR, offering insights into global spread and evolution.
#OneHealth

www.nature.com/articles/s41...

Incidence and prevalence of antimicrobial resistance in outpatients with cancer: a multicentre, retrospective, cohort study AMR proportions and IRRs for most key pathogens were up to three-times higher in isolates from outpatients with cancer than those without cancer, highlighting the need for enhanced surveillance, infec...

This large multi-center study shows cancer patients are infected with #AMR bacteria at 1.2 to 3 times higher rates due to frequent hospital visits and antibiotic use. This highlights the need for better antibiotic #stewardship and surveillance in these patients.

www.thelancet.com/journals/lan...

Antibiotics in the global river system arising from human consumption Abstract. The presence of antibiotics in surface waters poses risks to aquatic ecosystems and human health due to their toxicity and influence on antimicro

🧪 Antibiotics in our rivers: a global problem

A new study has found that 8,500 tonnes of antibiotics from human use end up in rivers every year. In 6 million km of rivers, levels are high enough to harm ecosystems or promote resistance.

🔗 doi.org/10.1093/pnas...

#SciComm #WaterQuality #AMR

Interesting webinar coming up on antimicrobial clinical trials conducted after marketing
#antimicrobial #AMR #ID
@steventong.bsky.social #PatrickHarris @gardp.bsky.social

register.gotowebinar.com/register/755...

Sprinkles and washes ... the true extent of topical rifampicin use during surgery is unclear due to lack of documentation - a huge opportunity for stewardship and better governance
bit.ly/42nFmQT
Thanks to my co-authors Matt Rawlins and @edraby.bsky.social

#AMS #off-label #rifampicin #AMR #NAUSP

Price of pretomanid to drop by 25% to increase accessibility for patients with TB. Great example of how global public-private partnerships can increase access to antimicrobials while maintaining economic viability for manufacturing #TB #publichealth #antimicrobials

www.stoptb.org/news/global-...

Safe and effective use of vancomycin Vancomycin is an important antimicrobial for the treatment of Gram-positive infections. To optimise efficacy and minimise toxicity, monitoring the area under the vancomycin concentration–time curve ov...

Great comprehensive summary on the safe & effective use of vancomycin in the Australian Prescriber
australianprescriber.tg.org.au/articles/saf...
Congrats to the authors! @leggwamy.bsky.social @tonylai.bsky.social @feliciadevchand.bsky.social @amandagwee.bsky.social Indy Sandaradura
#vancomycin #AMS

Large study ties early-life antibiotic exposure to higher risk of asthma, allergies, other conditions

The authors of the observational study say the findings highlight the need for more judicious antibiotic prescribing in children under age 2.

www.cidrap.umn.edu/a...

More than 3 million child deaths in 2022 linked to antimicrobial resistance

Deaths due to antimicrobial resistance are increasing, especially in children in South East Asia and Africa.

New study estimates 3 million kids died in 2022 globally due to AMR @cidrap.bsky.social #AMR #publichealth #mortality #antibioticresistance

www.cidrap.umn.edu/antimicrobia...

Go where the money is? No go where the AMR is.
Asia remains the epicenter of antimicrobial resistance, yet is underrepresented in clinical trials.
David Paterson’s keynote at #ESCMIDGlobal 2025 @escmid.bsky.social
underscores the urgency the need for urgent action 🙌
#AMR #ESCMIDGlobal2025

The most anticipated RCT in ID
🔥SNAP RCT🔥The largest RCT 2 date in SA bactermia
N:1341
Cefazolin Vs ASPs ((flu)cloxacillin) for MSSA bacteremia
Cefazolin is non-inferior (90d mortality)& less AKI than ASPs
A practice-changer RCT that must change the guidelines
#ESCMIDGlobal #IDSky

@steventong.bsky.social presents the results of the PSSA domain of the SNAP 🫰 trial - the worlds largest trial of staph aureus bacteremia - at #ESCMID2025

fluclox resulted in higher mortality and more AKI compared to penicillin for PSSA

JAMA review of Staph aureus bacteraemia.
Empiric treatment should include MRSA cover in areas with rates >5% or in patients with risk MRSA risk factors
#SAB @jama.com @steventong.bsky.social

Here’s who topped the rankings in this year’s scorecard for sustainable chocolate – and which confectionery giant refused to participate The global Chocolate Scorecard evaluates traders and brands on efforts to address child labour, deforestation and other measures.

Guide to buying sustainable chocolate this Easter 🐰🐇
#GoodEgg versus #BadEgg
@theconversation.com

#antislavery #climatesmart #sustainability #genderequity

theconversation.com/heres-who-to...

Timely access to appropriate antimicrobials is essential for patient care, antimicrobial stewardship & minimising the risk of resistance - excellent summary of the issues here: amr.solutions/2025/04/07/y...

Thanks to @johnhrexmd.bsky.social for highlighting our paper

#AMR #AntibioticAccess #AMS 💊

🔔 NEW in the Medical Journal of Australia

Shortages of benzathine benzylpenicillin G in Australia highlight the need for new sovereign manufacturing capability

✍️ Rosemary Wyber, Glenn Pearson and Laurens Manning

OPEN ACCESS www.mja.com.au/journal/2025...

Fantastic (& FREE) presentation from Assoc Prof Hayley Blackburn on reducing medication waste in hospitals. Pharmacy can lead on this! Medicines are key contributors to the healthcare carbon footprint & cause water pollution

adpha.au/event/medsaw...

#RxforClimate #OneHealth #AdPhA #AMR #medwaste

Exceedingly high levels of tetracycline resistance in Neisseria gonorrhoeae in eight WHO Enhanced Gonococcal Antimicrobial Surveillance Programme countries in three WHO regions, 2021–2024—doxycycline ... AbstractObjectives. Doxycycline post-exposure prophylaxis (doxycycline-PEP) can reduce incident cases of syphilis, chlamydia and possibly gonorrhoea especi

#WHO study shows high gonococcal resistance to #tetracycline (92% isolates in 8 countries)

#DoxyPEP unlikely to reduce gonorrhoea. Adverse impact to consider: selection of MDR gonococcal strains, impact on other pathogens & commensals

doi.org/10.1093/jac/... #AMR #EGASP @bsacandjac.bsky.social

New report scoping data capture in residential aged care facilities aehrc.csiro.au/wp-content/u...

No mention of external care providers using different documentation systems for IV meds, a data gap highlighted by Maher et al: doi.org/10.1016/j.ja...

#medicines #agedcare #RACF @csiro.bsky.social

The access pathway for unregistered medicines in Australia is used extensively to access antimicrobials, including for life-threatening infections
Difficulty accessing appropriate antimicrobials is not only a problem affecting LMICs
doi.org/10.1093/jaca...
@nadinehillock.bsky.social

Do policies that allow access to unregistered antimicrobials address the unmet need? Australia as a case study of a high-income country with universal healthcare AbstractBackground. Ensuring timely and equitable access to effective and optimal antimicrobials is crucial for optimal patient care, to minimize the use o

On average, 15–16 patients/day require an antibacterial not registered for use in Australia

Highlights that new pathways are needed to register antibacterials for otherwise untreatable infections

doi.org/10.1093/jaca...
@jac-amr.bsky.social @drewabow.bsky.social @peripatetical.bsky.social #AMR

Monitoring progress on antimicrobial resistance in the WHO African Region - World Analysis in English on World about Health; published on 14 Feb 2025 by WHO

WHO report warns AMR is now a top killer in Africa, surpassing malaria, HIV, and TB, with 1.05M deaths in 2019. Poor drug access, substandard meds, and antibiotic overuse fuel the crisis. #AMR #GlobalHealth #OneHealth#AMR #GlobalHealth #OneHealth

reliefweb.int/report/world...