Matthew Conroy

August's #LipidoftheMonth is also #LipidoftheMoth. It's identification took a whole lot of work, and even more moths! lipidmaps.org/updates/lipi...

Abuse of a commonly available drug can deplete June's #LipidoftheMonth, leading to very severe consequences.
www.lipidmaps.org/updates/lipi...

In which I am regrettably restrained in the fish pun department

Can't identify
a lipid by weighing it.
Misannotation

O cholesterol
how you clog the arteries
way to waxy death

What makes a lipid?
No two scientists agree
Fatty free-for-all

If an IBS patient has significantly altered levels of 20-HETE-d6 (yes, deuterium!) then perhaps your paper is a higher impact than you think. Alternatively....

Penguin attempts flight. Fails

April's #LipidoftheMonth is abundant on Earth, but has just been detected on Mars. www.lipidmaps.org/updates/lipi...

It's been a busy weekend! After taking part in the world record on Friday, we were off to help clean the Afon Lwyd in Croesyceiliog on Saturday, then to St Mellons today. Over 50 bags of rubbish, plus the usual trolleys, tyres etc each day.
More pics on Flickr at www.flickr.com/photos/cardi...

I keep being told AI is the way forward. Not for knowing the day of the week it isn't

We've events coming up this Friday and Saturday. Cardiff Bay and Cosmeston Lakes.

More details on the CRG website: cardiffriversgroup.org.uk/events/

Group of litter pickers standing behind a pile of litter including red bags , car tyres and metal.

Yesterday, we tackled Roath Brook, Sainsbury's car park, and Colchester Avenue:
23 volunteers
68 bags of rubbish
62 tyres
8 trolleys
1 skull*
a large number of other items

Thanks @cardiffcouncil.bsky.social who collected everything.
cardiffriversgroup.org.uk/roath-brook-...
*polystyrene, not real!

There's a growing interest in March's #LipidoftheMonth, how vital a molecule is it?
lipidmaps.org/updates/lipi...

Clearing fly-tipping. A montage of a pool full of bags of litter, three people in wellies clearing it, and the empty pool

Yesterday morning, our fantastic volunteers cleared around 100 bags of litter from around Fisherman's Quay on the banks of the river Ely.

cardiffriversgroup.org.uk/fishermans-q...

This Sunday we're going to tackle some fly-tipping on the banks of the River Ely, and also some habitat management in nearby Grangemoor Park. All are welcome to come and make a DIFFerence!

cardiffriversgroup.org.uk/event/fisher...

UPLC–QTOF-MS-Based Plasma Lipidomic Profiling Reveals Biomarkers for Inflammatory Bowel Disease Diagnosis Identification of new biomarkers may help in the early diagnosis of inflammatory bowel disease (IBD). In this study, ultrahigh-performance liquid chromatography equipped with quadrupole time-of-flight mass spectrometry (UPLC–QTOF-MS) was used to analyze the untargeted lipidomics and compare plasma lipid profiles between IBD patients and control subjects. The principal component analysis and partial least-squares-discriminant analysis were carried out to distinguish IBD patients from control subjects. Using univariate and multivariate analysis, 55 significantly different metabolites from five lipid classes, fatty acyls (n = 19), glycerophospholipids (n = 5), prenol lipids (n = 10), sphingolipids (n = 2), and sterol lipids (n = 19) were identified. Forty-four of the 55 metabolites were analyzed by receiver operating characteristic (ROC) curve and area under curve (AUC) of >0.80. After validation in an independent cohort, IBD patients were differentiated from the control subjects by significantly altered plasma level of palmitic acid, 7alpha, 25-dihydroxycholesterol, 20-hydroxyeicosatetraenoic (HETE)-d6, (+/−)5,6-epoxy-eicosatrienoic acid (EpETrE), docosahexaenoic acid (DHA), 9-heptadecylenic acid, lactucaxanthin, α-carotene, traumatic acid, and neoquassin with both sensitivity and specificity above 80%. Pathway analysis suggested that IBD dysregulation was related to the biosynthesis of primary bile acid, the metabolism of arachidonic acid, the metabolism of sphingolipid, fatty acid elongation, and glycerophospholipid metabolism. Our results suggest that the lipidomic profiling of patients plasma could be a potential method for IBD diagnosis.

This paper discovered levels of 20-HETE)-d6 - a deuterium labelled molecule - were altered in IBD patients. Do authors not think, nor reviewers read??

#NonsenseinLipidomics

doi.org/10.1021/acs.jproteome.9b00440

January's #LipidoftheMonth is a very common molecule with a festive connection. lipidmaps.org/updates/lipi...

Over the holiday, the number of molecules in @lipidmaps.bsky.social database LMSD has gone over 49k

One of my many jobs for the new year is to go through this one!

Productive morning with @cardiffrivers.bsky.social managing habitat in Grangemoor Park

#deadhedge #Sunday #nature #volunteers #cardiff

Could be pyoverdin, produced by various pseudomonas sp

December's #LipidoftheMonth is one with a seasonal feel.

www.lipidmaps.org/updates/lipi...

@mcmandiana.bsky.social The bridge over a drainage ditch into the Rhymney between Draethan and the Iron Bridge at ///bonfires.wacky.rural is in a dangerous state. Is this a Caerphilly CBC issue?

Anders Celsius would be 323 today (or 613 in F)

Earlier this week we partnered with recruits from South Wales Fire & Rescue Service, @keepwalestidy.bsky.social & Cardiff Harbour Authority to clean up an area of Cardiff Bay where litter collects. 126 bags and 2 skips of loose litter were removed. More pics at www.flickr.com/photos/cardi...

Cardiff Rivers Group Volunteers partnered with recruits from South Wales Fire & Rescue Service, Keep Wales Tidy and Cardiff Harbour Authority to clean up an area of Cardiff Bay where litter collects f... TikTok video by Cardiff Rivers Group

Morning well spent with @cardiffrivers.bsky.social
www.tiktok.com/@cardiffrive...

Over the water in Cardiff too