Michele Wölk

FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.

Excited to share my postdoc work @olzmannlab.bsky.social! We found lipid droplets, the cell’s lipid storage depots, are subject to oxidative damage and are protected by FSP1. Loss of FSP1 triggers droplet peroxidation and cell death, revealing a new layer of lipid quality control!

shorturl.at/B5XYD

FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.

Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...

Riboflavin metabolism shapes FSP1-driven ferroptosis resistance Membrane protection against oxidative insults is achieved by the concerted action of glutathione peroxidase 4 (GPX4) and endogenous lipophilic antioxidants such as ubiquinone and vitamin E. Deficienci...

🚨Preprint alert 🚨

We identify riboflavin (vitamin B₂) as a key modulator of ferroptosis sensitivity via stabilizing FSP1 & recycling lipid-soluble antioxidants.

www.biorxiv.org/content/10.1....

pls check @olzmannlab.bsky.social

www.biorxiv.org/content/10.1...

#ferroptosis #FSP1 #antioxidants

Screening of Protein Carbonylation Sites in Human Serum by Ion Mobility Mass Spectrometry Excessive oxidative stress, associated with various diseases, can induce protein carbonylation-nonenzymatic modifications involving aldehyde or keto group formation. These modifications are structural...

Happy to finally share my last contribution of my PhD work on protein carbonylation. These diverse and low abundant non-enzymatic PTMs have strong implications in protein structure. Here we show how we managed to consistently detect them in serum of 68 individuals.

pubs.acs.org/doi/10.1021/...

Sex-specific lipidomic signatures in aortic valve disease reflect differential fibro-calcific progression - Nature Communications Fibro-calcific aortic valve disease is closely interlinked with dyslipidemia. Here, the authors used quantitative lipidomics to profile the metabolic trajectories in human aortic valves, and found tha...

Happy to share our latest #Lipidomics results: Together with Patricia Prabutzki & @fedorovalab.bsky.social we looked at lipidome remodeling along development of fibro-calcific aortic valve disease. Turns out, it is quite different in male & female patients!
tinyurl.com/2bpujp8p

Please repost: Deadline extended until May 1st - join us for discussing cutting-edge cardiometabolic basic and translational research!

Outstanding speaker lineup, highly interactive program, ca. 35 short talks selected from abstracts, and the most beautiful venue at Lake Starnberg: eas-elc.org

Recommendations for robust and reproducible research on ferroptosis Nature Reviews Molecular Cell Biology - Ferroptosis is a non-apoptotic type of cell death that is induced by uncontrolled iron-dependent phospholipid peroxidation and has important roles in...

Important walkthrough for newcomers in the field
rdcu.be/eg58p

We will be hosting the first @mzmine.bsky.social Community Meeting at @iocbprague.bsky.social. Please register if you wish to learn about the latest developments in mzmine. More info: docs.google.com/document/d/1...

Job alert 🧪 ‼️ Hi #teammassspec: In our #RTG2467 @unihalle.bsky.social we have a job opening for a PhD student in my group! 🎉 If you want to do cool stuff in cross-linking mass spectrometry of the tumor suppressor p53, please take a look:
personal.verwaltung.uni-halle.de/jobs/wissmi/
Please RT!

Exciting times indeed! With so many new tools entering the field, we can hope to find the answers to many questions in lipid cell biology! Was happy to contribute to this viewpoint.

It’s incredibly hard to study lipids in biological membranes on the nanoscale. You need near-perfect information on both membrane ultrastructure and lipid density, which usually isn’t attainable. Lipid-CLEM brought to you by @mathilda95.bsky.social changes that.
www.biorxiv.org/content/10.1...

Ferroptosis triggers mitochondrial fragmentation via Drp1 activation Cell Death & Disease - Ferroptosis triggers mitochondrial fragmentation via Drp1 activation

Ever wondered how #mitochondria fragmentation comes about during #ferroptosis ? Read our new paper on Drp1-mediated promotion of ferroptotic #celldeath. Great @cecad.bsky.social collaboration with Ana Garcia Saez!

rdcu.be/d7L66

I am excited to report the preprint of my postdoc work in the @olzmannlab.bsky.social! We have discovered the first lipid droplet quality control pathway with broad implications for lipid physiology and diseases associated with LD accumulation and oxidative stress! #lipidtime

shorturl.at/2HqFd

FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis https://www.biorxiv.org/content/10.1101/2025.01.06.631537v1