Remember this all the time!

Jawdropping.

You would expect this in a dictatorship, not the United States.

This country is unrecognizable.

Abstract The ongoing emergence of severe acute respiratory syndrome coronavirus (SARS-CoV-2) variants of concern that reduce the effectiveness of antibody therapeutics necessitates development of next-generation antibody modalities that are resilient to viral evolution. Here, we characterized amino-terminal domain (NTD) - and receptor binding domain (RBD)-specific monoclonal antibodies previously isolated from COVID-19 convalescent donors for their activity against emergent SARS-CoV-2 VOCs. Among these, NTD-specific antibody C1596 displayed the greatest breadth of binding to VOCs, with cryo-electron microscopy structural analysis revealing recognition of a distinct NTD epitope outside of the site i antigenic supersite. Given C1596's favorable binding profile, we designed a series of bispecific antibodies (bsAbs), termed CoV2-biRNs, that featured both NTD & RBD specificities. Two of the C1596-inclusive bsAbs, CoV2-biRN5 and CoV2-biRN7, retained potent in vitro neutralization activity against all Omicron variants tested, including XBB.1.5, BA.2.86, and JN.1, contrasting the diminished potency of parental antibodies delivered as monotherapies or as a cocktail. Furthermore, prophylactic delivery of CoV2-biRN5 reduced viral load within the lungs of K18-hACE2 mice after challenge with SARS-CoV-2 XBB.1.5. In conclusion, NTD-RBD bsAbs offer promising potential for the design of resilient, next-generation antibody therapeutics against SARS-CoV-2 VOCs.

Diagram showing NTD Antibody + RBD Antibody leading to a combination labeled CoV2-biRN

More realistic diagram rather than the previous geometric one, showing NTD and RBD before and after the new approach has attached itself.

Umm, this is big COVID vaccine news. Nobody tell RFK Jr.

Original thread at link below.

THIS IS HUGE! Researchers at Stanford University have developed a dual-antibody treatment that remains effective against ALL SARS-CoV-2 variants by targeting a less-mutable […]

[Original post on mstdn.ca]

This Good News That's Bad For Trump Starts The Week Off Right Onward.

This Good News That's Bad For Trump Starts The Week Off Right

Fascism is here.

The list of words Trump is banning from government is the most stunning document of our time. Click the image below to see how many words Trump and Musk have canceled as part of their new Reich.

🔗: www.nytimes.com/interactive/...

Color photos of Elon Musk and Bernie Sanders, accompanied by this text: If Bernie's Social Security bill was enacted in 2021, Musk would have paid $2.9 billion more in taxes, Social Security would've been solvent for 75 years, benefits would have increased by $2,400 and 93% of Americans would have paid Zero more in taxes. The one 'entitled' is Musk.

WE'RE ENTITLED?
If Bernie's Social Security bill was enacted in 2021, Musk would have paid $2.9 billion more in taxes, Social Security would've been solvent for 75 years, benefits would've increased by $2,400 & 93% of Americans would've paid Zero more in taxes. The only one 'entitled' is Musk.

Today in Indigenous erasure and the whitewashing of our place names, cultures, and languages:

The climate crisis has struck Alaska so severely that half the state doesn't even have enough snow for winter recreation. The Iditarod had to be moved hundreds of miles north. The animals suffer in these conditions too, starving to death and unable to reach browse under winter rain conditions.

"NO KINGS LIVE HERE"

Evil.

Political cartoon. Rep Al Green, D-Texas standing up and pointing his cane yelling "HE DOES NOT HAVE A MANDATE TO CUT MEDICAID!" In the lower corner are two people hiding behind round signs. One reads "Civility!" and the other says "Did he not get the sign memo?"

“Speak up, speak out, get in the way. Get in good trouble, necessary trouble, and help redeem the soul of America.” – John Lewis

The man who issues threats daily and then immediately backs down from them has done it again. You better watch it, because next time he might really mean it.

I hope it passes!!

I finally had to turn it off and watch Kendrick Lamar’s half time show again.

Dems still sitting and not making noise

no smoke bombs
no Haka
#Krasnov #SOTU #Revolution2025 #resistanceKitty

This

HEY GOP; JUST DO IT!!!

Two market meltdowns.
One common denominator.

🇺🇦 Slava Ukrane 🇺🇦

Roberta Flack, ’70s R&B Vocalist Known for ‘Killing Me Softly,’ Dies at 88 Roberta Flack, best known for her '70s hits 'Killing Me Softly' (later covered by the Fugees) and 'The First Time Ever I Saw Your Face,' has died.

💔

variety.com/2025/music/n...

Do this. Say this. 👇🏻

PLEASE: Watch what happened in Coeur d'Alene Idaho today. This is fascism. Unmarked cops. 1A violations. RESIST.