Oleg Ko

This summary is exactly what you need to know about todays Nobel prize winners and their contributions to our understanding of the immune system

I am just catching up on Friday’s Marketplace…@kairyssdal.bsky.social is says that he’s been hosting the program for 20 years! That makes me a listener for the last 17. Started during the 2008 financial crisis, after just making a move to the US for grad school. Thank you Kai for all these years!

Some personal highlights from #CYTO2025:
* new unmixing algorithms for spectral flow from Dave Novo and Ozette
*systematic approach to autofluorescence analysis
* SOULCAP: initiative to standardize the cell type labeling in flow applications

Full house for the spectral flow cytometry session at #CYTO2025. Great news! This session is going to be recorded and available to view later!

This is true on so many levels! It takes time to pick the right reference controls, it definitely worth a few extra minutes to run them at a slower speed. #flowcytometry

Happy “Drive to Survive” Day to those who still celebrate. Just realized that it is the last Buxton season. #f1 #DTS

B cell immunometabolism in health and disease - Nature Immunology In this Review, Matarese and colleagues discuss how immunometabolism controls the physiology and pathophysiology of B cells.

Review @natimmunol.bsky.social
B cell immunometabolism in health and disease
www.nature.com/articles/s41...

FGF21 keeps the thymus young - Nature Aging Age-associated thymic involution causes a reduction in the de novo production of T cells, which results in limited self-protective immunity and an elevated risk of autoimmunity. Two studies have now i...

FGF21 keeps the thymus young @natureaging.bsky.social
Peptide hormone FGF21 acts on thymic epithelial cells to delay age-associated thymic involution and T cell imbalance
www.nature.com/articles/s43...
www.nature.com/articles/s43...
www.nature.com/articles/s43...
@annvgriffith.bsky.social

Sound a lot like USSR there KGB “watchers” were assigned to every department and plant/factory

Human naïve B cells recognize prepandemic influenza virus hemagglutinins Antibodies targeting the influenza hemagglutinin from potentially pandemic H5Nx viruses can be isolated from naïve individuals.

In #Science #Immunology this week: human naïve B cells can bind and neutralize #H5N1, potentially offering protection against #birdflu.

Spatial multi-omics has just gone to the next level!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
—Integration of 5 omic modalities w/ spatial resolution at 20 -50 μm
—"a new era for characterizing tissue & cellular heterogeneity that single-modality studies alone could not reveal"

Pretransplant targeting of TNFRSF25 and CD25 stimulates recipient Tregs in target tissues ameliorating GVHD post-HSCT https://www.biorxiv.org/content/10.1101/2025.01.16.633453v1

I am hiring for a postdoctoral fellow at UNC Chapel Hill in Child and Adolescent Anxiety and Mood Disorders Program (CHAAMP). The successful candidate will work on my NIH funded program of research on suicide risk among preteens. Please share. Deadline 1/31! unc.peopleadmin.com/postings/290...

Important resource! There is a tendency to treat children as miniature versions of adults.
🔦spotlight on childhood cancers:
🦠 immune responses to different types of cancer depending on age
🧬 relatively low TMB compared to adult cancers in TCGA
💉 guide the ise this data for precision medicine

An engineered immunogen activates diverse HIV broadly neutralizing antibody precursors and promotes acquisition of improbable mutations An immunogen engineered by computational and structure-based methods activated diverse B cell precursors and induced rare mutations in mouse models.

We are one step closer to the HIV vaccine. Great job, DHVI! #HIV #vaccines www.science.org/doi/10.1126/...

Restimulation by macrophages exhausts T cells Inhibiting T cell exhaustion is an attractive cancer immunotherapy strategy. In this issue of Immunity, Waibl Polania et al. examine the microenvironmental signals regulating terminal T cell exhaustio...

@ImmunityCP preview:
Restimulation by macrophages exhausts T cells
www.cell.com/immunity/ful...
on
www.cell.com/immunity/ful...

icCITE-seq (intracellular cellular indexing of transcriptomes and epitopes), a scalable method that simultaneously measures surface and intracellular protein levels alongside gene expression across thousands of cells
doi.org/10.1101/2025...

Got Senna’s McLaren MP4/4 Lego set for Christmas. Now I am watching Senna while building Senna’s racing car #F1 #Senna

This reminds me of my childhood when we’d have buckets of cabbage undergoing fermentation process all over our small kitchen

New in Science Magazine this week: two research articles and a Perspective describing synthetic biology gene circuitry for bespoke cellular function - in this case applied to T cells!

Research:
buff.ly/41pkAAb
buff.ly/41gMxu0

Perspective
buff.ly/3ZFUUy8

@science.org

Taking the STING out of radiotherapy: STING checkpoints mediate radiation resistance: https://www.jci.org/articles/view/186547

Michael C. Brown et al. comment on a pair of articles by Wen et al. (https://www.jci.org/articles/view/181612) and Zhang et al. (https://www.jci.org/articles/view/181044)

a close up of a woman 's face with a surprised look on her face . ALT: a close up of a woman 's face with a surprised look on her face .

#ASH24 Energy matters! Ketogenic Diet Enhances CAR T Cell Antitumor Function Via β-Hydroxybutyrate #CARTCell #TCell #tcellrx #immunotherapy @PennMedicine
ash.confex.com/ash/2024/web...

A good reminder that I should up my monthly contribution to this fine enterprise.

Even more reasons to migrate to BlueSky

A good reminder that fluorescent protein (FP) labels can affect the interaction of the tagged protein with other molecules depending on on the nature of FP and its position ( C- vs N- terminus)

Fluorescent Tags Are Basically Never Silent

Fluorescently labeled proteins are essential to research. But we should never forget how messed-up their behavior can be. An example from condensates:

Bluesky boom worries Chinese media | Semafor State outlets, which put considerable resources into amassing millions of followers on Elon Musk’s social media platform, have recently seen their growth plateau.

Ok, this did it. This told me that BlueSky is doing something right.

Hello everyone.

www.semafor.com/article/11/2...

My favorite resources from Twitter are slowly coming to BlueSky!

Who doesn’t like a good coffee + microbiome + biochem study?!

Just reposted one with verified F1 journos