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gouthamnarla

@gouthamnarla.bsky.social

physician scientist, professor of medicine, drug hunter, biotech entrepreneur, father, husband, lover of food, wine, and golf

40 Followers  |  231 Following  |  2 Posts  |  Joined: 17.02.2025  |  1.4258

Latest posts by gouthamnarla.bsky.social on Bluesky

Abstract B051: Discovery of SW-3431, a first-in-class molecular glue activator with potent and selective anti-tumor activity in PPP2R1A mutant cancers AbstractUterine cancer is the only cancer type for which survival has fallen in the past four decades. This past year, uterine cancer deaths surpassed ovarian cancer for the first time: making uterine...

Abstract B051: Discovery of SW-3431, a first-in-class molecular glue activator with potent and selective anti-tumor activity in PPP2R1A mutant cancers url: aacrjournals.org/mct/article/...

23.10.2025 12:31 โ€” ๐Ÿ‘ 2    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Preview
Mutant PP2A Induces IGFBP2 Secretion to Promote Development of High-Grade Uterine Cancer Elevated IGFBP2 secretion by uterine cancer cells with heterozygous PPP2R1A mutations supports tumor progression and confers a vulnerability to IGFBP2/IGF1R inhibition as a therapeutic approach for th...

Our new paper describing how mutations to the PP2A gene PPP2R1A drive high-grade uterine cancers is out now in this issue of Cancer Research by @theaacr.bsky.social

aacrjournals.org/cancerres/ar...

05.02.2025 17:19 โ€” ๐Ÿ‘ 5    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Molecular Glue Boosts PP2A, Overcoming Resistance to RAS/MAPK Inhibitors in KRAS-Mutant Lung Cancer, Enhancing Survival Rates.

by Raines B, Tseng-Rogenski S (...) Narla G et 14 al. in J Clin Invest #MedSky

๐Ÿ‘‰ get more here

๐Ÿ“– read the article: https://www.jci.org/articles/view/193790

23.10.2025 04:34 โ€” ๐Ÿ‘ 4    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
JCI - A PP2A molecular glue overcomes ras/mapk inhibitor resistance in kras-mutant non-small cell lung cancer

Exciting new finding about the role of PP2A molecular glues in overcoming resistant to broad classes of MAPK inhibitors in KRAS driven cancers
JCI - A PP2A molecular glue overcomes ras/mapk inhibitor resistance in kras-mutant non-small cell lung cancer www.jci.org/articles/vie...

21.10.2025 14:00 โ€” ๐Ÿ‘ 7    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

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