CCMN

Thanks to @theiups.bsky.social 2025 meeting for a great Vascular Health and Function session where I was pleased to share exciting new data!

Dr Cecilia Skoug presenting the latest mouse behaviour data from the Trapp lab at @theiups.bsky.social. Great presence from @ccmnlondon.bsky.social at a fantastic meeting!

Another day, another excellent talk from a @ccmnlondon.bsky.social member. Dr. Anna Robert’s from @adriaenssenslab.bsky.social lab presented her work on GIP and vascular health here at @theiups.bsky.social 2025 meeting in Frankfurt.

More @ccmnlondon.bsky.social representation at #IUPS2025; Philippa Wittenberg, PhD student in Prof. Alex Gourine’s group presented her work on the baroreceptor mechanism.

Last conference for the year for me is IUPS 2025. Yesterday was the well-attended symposium ”GLP-1 Receptor Agonists - a Magic Bullet Beyond Diabetes and Obesity?” Chaired by Prof. Stefan Trapp @trapp-lab.bsky.social Maybe I’m
biased but a great symposium indeed! @ccmnlondon.bsky.social

Proud PI moment #1:

@phoebeclax.bsky.social doing a stellar job in her first ever conference poster session, presenting data generated during her @bsneuroendo.bsky.social funded undergraduate summer lab experience project.

#BSNBradford2025

Proud PI moment #2:

Superstar postdoc @laurenjonesucl.bsky.social absolutely smashing her first conference presentation of her fascinating data on #semaglutide mechanism of action.

#BSNBradford2025

Pleased to share a new paper that I'm proud to have contributed to 🌟 Grateful for the chance to work with such a talented team 🙌

Really enjoyed working on this - big thanks to everyone involved!

Fluorescent GLP1R/GIPR dual agonist probes reveal cell targets in the pancreas and brain - Nature Metabolism A series of fluorescent probes is designed that act as dual agonists on both GLP1 and GIP receptors, and are used to image receptor binding activities in tissues and animals.

Interested in brain access for Tirzepatide-based drugs? Have a look at the fluorescent Tirzepatide analogue developed by Johannes Broichhagen and David Hodson @daveyboyhod.bsky.social‬ out now in Nature Metabolism www.nature.com/articles/s42.... Proud to contribute to this great multi-lab effort.

📣 New paper out exploring brain access of Tirzepatide based fluorescent analogues! We are proud to have contributed to this multi-lab effort.

Unbelievably proud of @nataliefigueredob.bsky.social for winning the prestigious Bogue Fellowship 🌟 She'll be heading across the pond to train with the @zknight.bsky.social lab for 3 months. Exciting things to come for this bright young scientist 🧠. @uclnpp.bsky.social @ccmnlondon.bsky.social

Targeting GLP-1 in the brain could transform obesity care Explore the role of GLP-1 in regulating hunger and appetite, uncovering its complex mechanisms in the brain and gut.

Can targeting GLP-1 in the brain revolutionise obesity treatment? 🧠💉

Check out Professor Stefan Trapp’s take on how central GLP-1 pathways could transform the future of obesity care.

www.drugtargetreview.com/article/1606...

Redefining respiratory sinus arrhythmia as respiratory heart rate variability: an international Expert Recommendation for terminological clarity - Nature Reviews Cardiology The physiological phenomenon whereby heart rate varies in phase with breathing in vertebrates has been known as ‘respiratory sinus arrhythmia’. In this Expert Recommendation, the authors argue that th...

📣 New publication alert!

“Redefining respiratory sinus arrhythmia as respiratory heart rate variability: an international Expert Recommendation for terminological clarity” is now out!

Read the full article here:

www.nature.com/articles/s41...

GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice - Nature Metabolism This study, together with a companion manuscript, show that, in mice, weight loss as a result of GIP receptor antagonism requires, and potentiates, functional GLP-1 receptor signalling in the brain, e...

It's a big week for GIPR pharmacology! Two great studies out in @natmetabolism.nature.com from Gutgesell et al (www.nature.com/articles/s42...) and Liu et al (www.nature.com/articles/s42...) revealing divergent neural mechanisms engaged by GIPR agonism vs antagonism. Commentary here: rdcu.be/ejPSA

UCL – University College London UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

We are recruiting! If you are interested in working as a post-doctoral Research Fellow in the heart of London contributing to MRC-funded research into GLP-1 action within the brain, please look at this link and apply if interested: www.ucl.ac.uk/work-at-ucl/...

UCL – University College London UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

www.ucl.ac.uk/work-at-ucl/...

📣Join the Trapp lab as a Postdoctoral Research Fellow!

The Trapp lab is seeking for a highly motivated Research Fellow to explore the role of GLP-1 action within the brain. If you are interested we encourage you to apply!

📍 Location: UCL, London
📆 Application deadline: March 19th

Harnessing hormones for health: Taking GLP-1 from research to reality Learn about the groundbreaking science research behind the GLP-1 revolution - join us on 6 March

@uclnpp.bsky.social @ucl.ac.uk @rsc.org @ucllifesciences.bsky.social @bsneuroendo.bsky.social @ssibsociety.bsky.social

www.chemistryworld.com/webinars/har...

📣 Professor Stefan Trapp will be giving a talk as part of the webinar titled Harnessing Hormones for Health: Taking GLP-1 from Research to Reality hosted by @chemistryworld.com

Join to learn all about the groundbreaking science behind obesity drugs on March 6th at 3:00pm.

Non-invasive vagus nerve stimulation and exercise capacity in healthy volunteers: a randomized trial AbstractBackground and Aims. Vagal parasympathetic dysfunction is strongly associated with impaired exercise tolerance, indicating that coordinated autonom

doi.org/10.1093/eurh...

📣 New study from @AcklandLab and CCMN in #EHJ! This randomized, double-blind, sham-controlled, crossover trial in healthy volunteers shows that vagal stimulation increases peak O₂ consumption and power output during exercise and has a strong anti-inflammatory effect.

On the regulation of arterial blood pressure by an intracranial baroreceptor mechanism Abstract figure legend This experimental animal (rat) study describes the regulation of systemic arterial blood pressure by an intracranial baroreceptor mechanism sensitive to changes in brain perfus...

📣 A new paper from the Gourine lab led by Pippa Wittenberg, came out this week! Check it out to learn about the existence of an intracranial baroreceptor mechanism that regulates cerebral blood flow.

physoc.onlinelibrary.wiley.com/doi/10.1113/...

📣 @wanqingjiang.bsky.social from the @trapp-lab.bsky.social successfully defended her PhD thesis. Congratulations 🎓 !!

GLP-1 and the Neurobiology of Eating Control: Recent Advances Abstract. Obesity is now considered a chronic relapsing progressive disease, associated with increased all-cause mortality that scales with body weight, af

📣 @laurenjonesucl.bsky.social and @drdanbrierley.bsky.social published a new review on the role of GLP-1 in eating and obesity treatment!

academic.oup.com/endo/article...

CCMN is off to an amazing start this year. Here are some highlights you don’t want to miss ✨

Zack night in a lecture hall

Group of people at pub table

Group of people in bowling alley

Fantastic departmental seminar by @zknight.bsky.social, followed by craft beer and bowling for xmas party with the @ccmnlondon.bsky.social crew.

Definitely a Good Science Day.

📣 We are excited to launch this year’s CCMN Lecture Series with Dr. @zknight.bsky.social! Join us to learn about his latest work on:
In vivo imaging of brainstem neurons in response to nutrient intake.

🗓️ Wednesday, Dec 4, 2024
🕐 13:00
📍 H O Schild Lecture Theatre, Medical Sciences Building

The Trapp Lab has moved to BlueSky. No better way to start this than with a new paper.
We are excited to alert you to the latest study on the involvement of brain GLP-1 in stress responses led by our @CCMN_London and Trapp Lab
alumni @MKBHolt

Read the details at doi.org/10.1016/j.mo....