Angela Gonçalves

Thank you to Klaudija Daugelaite, Ivana Winkler, the Odom and Rehnitz labs (at DKFZ and UKHD), it has been a pleasure working with you. Thank you to the DFG and ERC for funding.

Also, most oocyte aging studies use superovulated cells. Here we show that aging and superovulation lead to qualitatively similar transcriptomic changes, but that superovulation response is milder in old age. This highlights the necessity of including nat. ovulated cells in oocyte aging studies.

Using a mouse model, we characterize the transcriptional maturity of superovulated oocytes and granulosa cells after hormonal stimulation and identify markers in granulosa cells that are predictive of the oocyte early developmental potential.

Increased reproductive age and the development of assisted reproductive technologies (ART) are shaping modern human reproduction. Understanding how these new conditions impact oocyte quality is crucial to improve the efficiency of fertility treatments.

We are happy to announce that our article on the impact of #superovulation and #aging on mouse #oocyte and #granulosa cells is out in Nature Communications! www.nature.com/articles/s41...

Beyond the standard: Unconventional vertebrate models in biomedicine The use of a handful of model organisms has proven essential for scientific discovery and to unlock new therapeutics to combat human disease. As society looks to the future, the gateway to new scient…

Excited to be in the lineup for the next EMBO workshop on unconventional vertebrate models in biomedicine! #EMBOvertrebateModels meetings.embo.org/event/25-ver...

Thank you Elisa!

Thank you Sylvia!

Sworn in as Professor of @uniheidelberg.bsky.social on leave @dkfz.bsky.social, thank you to everyone who supported me!