New study shows that TGFฮฒ signaling is crucial for maintaining microglial resilience to myelin degeneration during aging.
This highlights a previously unresolved checkpoint of TGFฮฒ signaling with regional specificity and spatially restricted microgliaโoligodendrocyte interactions.
05.01.2026 20:40 โ ๐ 9 ๐ 4 ๐ฌ 1 ๐ 0
New stem cell approach could repair stroke-damaged brains
Explore the impact of stroke and the latest research on stem cell therapy aimed at improving recovery from ischemic strokes.
Check out the news article about our recent work on cell therapies for stroke by Drug Target Review:
www.drugtargetreview.com/news/187869/...
More info about the original study can be found here:
www.nature.com/articles/s41...
05.01.2026 00:57 โ ๐ 6 ๐ 1 ๐ฌ 0 ๐ 0
Electroacupuncture alleviates blood-brain barrier disruption and neuroinflammation via astrocytic MC4R in a mouse model of multiple sclerosis
04.01.2026 16:16 โ ๐ 3 ๐ 2 ๐ฌ 1 ๐ 0
Eleven clinical trials that will shape medicine in 2026
Happy to see a lot of cell-based therapies!
04.01.2026 16:14 โ ๐ 3 ๐ 2 ๐ฌ 1 ๐ 0
hiPSC-derived Neural Progenitor Cells support long-term (43 dpi) graft neuronal integration & functional recovery after photothrombotic Stroke๐ญ
๐57% neurites extend along cc into contralateral hemisphere
Graftsโถ๏ธ44% GABAergic Neurons
@rrust.bsky.social #NatComm 2025
www.nature.com/articles/s41...
01.01.2026 14:20 โ ๐ 7 ๐ 3 ๐ฌ 0 ๐ 0
CleLight: A scalable 3D histology pipeline for mappingneu...
Mesoscopic brain imaging, enabled by advances in tissue cleari...
CleLight: A scalable 3D histology pipeline for mappingneurodegenerative and psychiatric pathology in archivalhuman brains www.researchhub.com/paper/105900...
21.12.2025 03:18 โ ๐ 2 ๐ 0 ๐ฌ 0 ๐ 0
โTime is brainโ for cell therapies?๐ง
Our #AdvSci perspective๐
@rrust.bsky.social
@dominikusbrian.com
@lydenlab.bsky.social
#StemCellTherapy for #Stroke should be timed to a biomarker-defined โwindow of receptivityโ, not just the thrombolysis clock
advanced.onlinelibrary.wiley.com/doi/10.1002/...
18.11.2025 20:06 โ ๐ 26 ๐ 4 ๐ฌ 0 ๐ 1
New in @natureportfolio.nature.com on microglial regulation in Alzheimerโs disease. The study shows that microglia with low PU.1 expression and surface CD28 reduce amyloid pathology and inflammation. It highlights immune co-stimulatory pathways as potential targets in AD. Very interesting!
07.11.2025 22:13 โ ๐ 11 ๐ 3 ๐ฌ 2 ๐ 1
Great work ๐ mapping how brain endothelial cells communicate with astrocyte endfeet at the bloodโbrain barrier in @natureportfolio.nature.com
The study identifies ligandโreceptor pairs conserved in humans and altered in MS and Alzheimerโs.
Makes me also wonder how many could be druggable targets.
06.11.2025 18:50 โ ๐ 13 ๐ 5 ๐ฌ 1 ๐ 0
Interesting new work @natureportfolio.nature.com showing that a small molecule identified through in silico transcriptome matching (thiorphan) enhances corticospinal regeneration after spinal cord injury. Combined with neural stem cell grafts, it improved forelimb recovery and axonal growth.
04.11.2025 19:44 โ ๐ 3 ๐ 1 ๐ฌ 1 ๐ 0
Interesting new work modeling human cholinergic circuitry! Researchers generated nbM organoids from hPSCs and fused them with cortical organoids to form functional nbMโcortical assembloids. This provides a platform to study deficits seen in Down syndrome. @cp-cellstemcell.bsky.social
04.11.2025 17:14 โ ๐ 2 ๐ 2 ๐ฌ 1 ๐ 0
The brain neurovascular epigenome and its association with dementia @cp-neuron.bsky.social
Great study that maps cell-type-specific regulomes showing that small vessel disease heritability spans the neurovascular unit, incl astrocytes.
These findings link vascular risk and Alzheimerโs mechanisms.
04.11.2025 05:32 โ ๐ 3 ๐ 2 ๐ฌ 1 ๐ 0
Pluripotent Cells Expressing APOE4 Exhibit a Pronounced Pro-Apoptotic Phenotype Accompanied by Markers of Hyperinflammation and a Blunted NF-ฮบB Response
www.mdpi.com/1422-0067/26...
30.10.2025 19:35 โ ๐ 4 ๐ 2 ๐ฌ 0 ๐ 0
Important study shows that a new 3D method can efficiently produce dopamine neuron precursors from stem cells. The researchers also tracked how these cells grow and connect after transplantation, big step for Parkinsonโs disease treatment!
cell.com/cell-stem-ce...
30.10.2025 15:48 โ ๐ 8 ๐ 4 ๐ฌ 0 ๐ 1
Great study dissecting molecular hallmarks of neuronal resilience in Alzheimerโs disease highlighting natural protective mechanisms that could help preserve cognition.
x.com/rust_ruslan/...
30.10.2025 14:24 โ ๐ 4 ๐ 0 ๐ฌ 0 ๐ 0
Can stem cells help to regain brain function after stroke?
Our new study in NatureComms @natureportfolio.nature.com shows that they can and dissect the key mechanisms driving recovery.
t.co/KRfAHfkNIH
21.09.2025 15:48 โ ๐ 26 ๐ 7 ๐ฌ 0 ๐ 0
Delayed Transplantation (7 vs 1 dpi) of #NeuralStemCell Improves Initial Graft Survival after #Stroke
โซgraft axon extension along #CorpusCallosum to contralateral hemisphere
@ctackenberg.bsky.social @rrust.bsky.social #AdvSci 2025
advanced.onlinelibrary.wiley.com/doi/10.1002/...
08.06.2025 11:47 โ ๐ 6 ๐ 3 ๐ฌ 0 ๐ 0
"Authentic" #hiPSC-derived #Pericyte ๐
Sharing highly similar proteome/phosphoproteome to primary๐ค๐ง cortical pericyte
Contractile
โซ #BloodBrainBarrier & Neuroprotective (Pdgfrb F7/F7๐ญ)
Clear Aฮฒ Tau (๐ง slices 5xFAD๐ญ APOE4 P3001S๐ญ)
@rrust.bsky.social bioRxiv 2025
www.biorxiv.org/content/10.1...
02.05.2025 19:30 โ ๐ 6 ๐ 2 ๐ฌ 0 ๐ 0
#hiPSC derived #Pericyte
๐>80% Home to & >50% Arborize on Capillaries in live๐ง slice of PdgfrbF7/F7๐ญ
in situ PDGFBB-PDGFRฮฒ PLA assay๐
๐โซAmyloidฮฒ clearance on 10-m/o 5xFAD ๐ญ๐ง slice
Are these phagocytic pericytes still vessel-bound?๐
@rrust.bsky.social bioRxiv 2025
www.biorxiv.org/content/10.1...
25.04.2025 11:32 โ ๐ 7 ๐ 1 ๐ฌ 0 ๐ 0
Custom CRISPRโCas9 PAM variants via scalable engineering and machine learning - Nature
Nature - Custom CRISPRโCas9 PAM variants via scalable engineering and machine learning
In @nature.com we describe the use of scalable #proteinengineering & #machinelearning to predict millions of bespoke CRISPR enzymes, offering safer & more efficient genome editing tools ๐งฌ๐ฅ๏ธ @rachelsilverstein9.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social
www.nature.com/articles/s41...
22.04.2025 20:56 โ ๐ 51 ๐ 21 ๐ฌ 3 ๐ 5
All things teammassspec/realtimechem. Survives on only the fanciest coffee and beer.
Laser capture microdissection | spatial proteomics | protein modification | atherosclerosis | inflammation and oxidation
Interested in how & what the brain computes. Professor in Neuroscience & Statistics UC Berkeley
scientist at UC Berkeley inventing advanced genomic technologies
lover of molecules, user of computers
https://scholar.google.com/citations?user=63ZRebIAAAAJ&hl=en
Postdoc in the School of Data Science, University of Virginia.
I mainly work on computational social science, science of science and network science.
Neuro postdoc at UCC ๐ฎ๐ช PhD at MPI-NAT, ๐ฉ๐ช | Alzheimer's x glia x sex differences x gut microbiome ๐ฌ๐ง | (he/they) ๐ณ๏ธโ๐
Postdoc at Baylor College of Medicine. Interested in glial biology, memory, neural repair. ๐จ๐ฆ
Professor and clinician, Physiology & Neuroscience, Neurology, Keck School of Medicine of USC #stroke #ischemia #thrombolytics
Papers is an award-winning reference manager that improves how you discover, annotate, collaborate and cite research.
Sign up for a 30-day free trial: linktr.ee/get_papers
Assistant Professor studying hypertension & dementia
BRAINS fellow โ22
she/her #LatiNeuro ๐จ๐ท
Post-doc at NKI-AVL - van Rheenen group - Two photon enthusiast- Vascular biologist-
Neuroscientist at the Federal University of Rio de Janeiro ๐ง๐ท
Interested in neuroimmunology, glial cells, and neurological disorders.
Focused on cancer and rare diseases. Project: 101059842 - CTGCT - HORIZON-WIDERA-2022. Co-funded by the European Union, the UK Research and Innovation (UKRI) and European Regional Development Fund EU under Sloveniaโs Cohesion Policy Programme 2021-2027.
Neurobiology of hypothalamus๐ง , Associate Professor
@mcgillu, mom to ๐ฆ๐ป๐ฆ๐ผ๐ถ, microscopy geek๐ฌ, and amateur baker๐ง and musician๐น
masha-prager-khoutorsky.lab.mcgill.ca
Science from the Zeiger Lab at UCLA. Neural circuits, stroke, movement disorders. zeigerlab.com
Web3 Early Projects and Airdrops
"Google Labs: Pioneering the Future of Innovation ๐ | Explore cutting-edge AI experiments, next-gen tools, and emerging technologies. Join us in shaping tomorrow's digital experience. ๐
https://labs.google
#GoogleLabs #Innovation"
Investigative reporter @sciencemagazine. Before: investigations for @statnews @sacbee_news @latimes. cpiller@charlespiller.com - Signal: cpiller.01 - Author of the book "Doctored: Fraud, Arrogance, and Tragedy in the Quest to Cure Alzheimer's"
SFโก๏ธSDโก๏ธTPAโก๏ธPDX (He/Him ๐ณ๏ธโ๐) Cancer Biologist/Rare Tropical Plant Enthusiast/Associate Prof studying all things Fuc, Fuk, & Futs. Champion for community support and advocacy. Ally. Views are my own.
