Thomas Nichols

a man is standing in a kitchen with his hands on his chest and asking for help . Alt: Tom Cruise is standing in a kitchen with his hands on his chest and asking for help, saying "Help me, Help you"

A systematic meta-analysis is hard work—and curation is often the hardest part. Y'all know this better than anyone, and we want to make it easier.

What’s one specific piece of information you consistently had to find or extract from every paper?
Tell us about it: tally.so/r/QKVbQG

#neuroscience

PROVIDENT: Best practice for PROspectiVe Imaging Research DEsign and coNducT. From @nihr.bsky.social Statistics's Imaging Studies section; harnesses many years of experience (& horror stories) integrating imaging into clinical trials.

Biscombe et al. doi.org/10.1016/j.ra...
doi.org/10.1016/j.ra...

Statistical Machine Learning post doc positions, w/ Oxford BDI-Novartis Collaboration for AI in Medicine, working on building causal predictive models for MS using a massive clinical trials MRI dataset. Join us on this unique collaboration!
my.corehr.com/pls/uoxrecru...
my.corehr.com/pls/uoxrecru...

Delighted to see that @ohbmossig.bsky.social has confirmed dates for the 2026 @ohbmofficial.bsky.social brain hack!
ohbm.github.io/hackathon2026/ 11-13 June Thur-Sat, in the usual 3 days before the meeting, at the Campus Victoire, University of Bordeaux

Looking forward to it!

Wrong Tom Nichols

AI in Medicine 2026 The most comprehensive review conference in internal medicine. 73 lectures, 20.5 CME credits. Organized by McMaster University, the home of EBM.

AiMed2026 - 7-9 May in Kraków - a dual-track program to bring together clinical and technical experts at the intersection of AI and medicine. Co-chaired by my brilliant @oxpop.bsky.social colleague @bwpapiez.bsky.social

piebm.org/campaigns/ai...

Excited to share our manuscript about BrainEffeX, a tool for exploring fMRI effect sizes. Includes why we made it, how to use it + contribute, and how we made it.

@sneuroble.bsky.social @psychonetrics.bsky.social
@alexkfischbach.bsky.social
@nichols.bsky.social
@dscheinost.bsky.social & MINDS Lab

Ten Simple Rules for AI-Assisted Coding in Science While AI coding tools have demonstrated potential to accelerate software development, their use in scientific computing raises critical questions about code quality and scientific validity. In this pa...

Ten Simple Rules for AI-Assisted Coding in Science arxiv.org/abs/2510.22254 - our latest, led by @ericwbridgeford.bsky.social

Alcohol use and risk of dementia in diverse populations: evidence from cohort, case–control and Mendelian randomisation approaches Objectives To investigate the relationship between alcohol consumption and dementia. Design Prospective cohort and case–control analyses combined with linear and non-linear Mendelian randomisation. ...

Happy to be a part of Anya Topiwala's new work, using Mendelian Randomisation with @ukbiobank.bsky.social & Million Veteran Program, finding that even modest alcohol consumption increases risk of dementia. ebm.bmj.com/content/earl...

𝐂𝐚𝐥𝐥 𝐟𝐨𝐫 𝐏𝐚𝐩𝐞𝐫𝐬 – 𝐒𝐩𝐚𝐭𝐢𝐚𝐥 𝐒𝐭𝐚𝐭𝐢𝐬𝐭𝐢𝐜𝐬 𝐢𝐧 𝐈𝐦𝐚𝐠𝐢𝐧𝐠

Special issue of 𝘚𝘵𝘢𝘵𝘪𝘴𝘵𝘪𝘤𝘴 𝘢𝘯𝘥 𝘋𝘢𝘵𝘢 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘪𝘯 𝘐𝘮𝘢𝘨𝘪𝘯𝘨, supported by @amstatnews.bsky.social ASA Sections on Statistics and the Environment (ENVR) and Statistics in Epidemiology (SIE)

Submission details:
tinyurl.com/47enwhwz

AI-driven reclassification of multiple sclerosis progression - Nature Medicine Using large cohorts from published clinical trials involving more than 8,000 patients with multiple sclerosis, a probabilistic machine learning model reconstructs the transition probabilities from data-derived diseases statuses, showing patterns that suggest how progression to severe stages occur and potential inversion of the process.

All made possible by an innovative Factor Analysis + Hidden Markov Model. See paper & supp for details

Ganjgahi et al. ‘AI-Driven Reclassification of Multiple Sclerosis Progression’. Nature Medicine, Nature Publishing Group, 20 August 2025, 1–11. doi.org/10.1038/s415....

Well known diagnostic labels (RRMS, SPMS, PPMS) do not explain these states, showing their limitations. This is an important contribution to developing more fully data-driven perspectives on MS disease heterogeneity.

This is a key output of the Oxford Big Data Institute-Novartis Collaboration for AI in Medicine. The paper represents a huge, collaborative effort, with replication done on data from another pharma company (Roche) and another large dataset (MS PATHS).

www.bdi.ox.ac.uk/research/oxf...

Epic work led by Habib Ganjgahi is out in Nature Medicine... data-driven clustering of MS finds 3 distinct states, early/mild, active, advanced, w/ transition to the advanced state only occuring through the active state... replicated twice!

doi.org/10.1038/s415...

This is a gem… really enjoyed reading about stats theory legend Gauss trudging across the countryside surveying.

Really nice study, and extends some of the ideas developed in this paper pubmed.ncbi.nlm.nih.gov/32673043/

For me, this work is a classic @ohbmofficial.bsky.social story: In 2023 I wasn't working with @bttyeo.bsky.social but I overheard him at his poster pointing to some accuracy curves saying "I don't why they have this particular shape". That kicked off the collab that led to these results.

1/11 Excited to share our @Naturestudy led by @leonooi.bsky.social @csabaorban.bsky.social @shaoshiz.bsky.social

AI performance is known to scale with logarithm of sample size (Kaplan 2020), but in many domains, sample size can be # participants or # measurements...

doi.org/10.1038/s415...

Wasn't aware of tinyplot... an overlay package to make base R graphics easier to use. While I use ggplot2 for some tasks there are many situations where I prefer base R plotting, and this tool will be super helpful in those seetings.

Artificial intelligence for electronic health records For our next talk, in Machine Learning, we will be hearing from Dr Shishir Rao, Senior Research Scientist, Deep Medicine research group, NDWRH, University of Oxford. We’re delighted to host Shishir in...

Looking forward to presenting our team's research on AI for EHR at The Big Data Institute at Oxford on July 10th at 2 pm! Thanks to Sumeeta and Prof @nichols.bsky.social for organising.

Link: talks.ox.ac.uk/talks/id/590...

Excited to share our latest preprint: "Neurosynth Compose: A Web-Based Platform for Flexible and Reproducible Neuroimaging Meta-Analysis"

Here, we cover the why, what, and how of the next generation Neurosynth ecosystem for reproducible neuroimaging meta-analysis.

osf.io/preprints/os...

Almost recovered from #OHBM2025... has anyone else found the E-posters nearly imposible to find. They are here, discoverable through the app and the browser-link-out button

ww6.aievolution.com/hbm2501/inde...

Public service announcement: Don’t forget to upload your #OHBM2025 poster PDF, at ww6.aievolution.com/hbm2501/

The beta release of SPM-Python is out now! Amazing work by Johan Medrano @johmedr.bsky.social , Yael Balbastre, Yulia Bezsudnova @ybezs.bsky.social and other members of their team. A new era for SPM! #OHBM2025

Interested in practical tips for assessing collinearity and why common fixes might not help? Come to the #OHBM2025 oral session Friday at 11:30AM (P2)! I’ll share simulation results and @demidenko.bsky.social will present real data. Also, check out my poster Thursday (1051)!

Is anyone else at #OHBM2024 educational courses maddened by the lack of time per-course schedule? In the app, the individual talks are listed *alphabetically* by talk title, all with the same start time. Same thing for symposia...

FYI, this link comes from Poster Presenter's page
humanbrainmapping.org/i4a/pages/in...

Useful #OHBM2024 deep link - Table listing all posters with stand-by times & categories

gmpartners365-my.sharepoint.com/:x:/g/person...

FYI, linked from Poster Presenters page
humanbrainmapping.org/i4a/pages/in...

Preserve the Open Science Room at the Organization for Human Brain Mapping Annual Meeting Can you spare a minute to help this campaign?

At #OHBM2025 the Open Science Room has been squeezed and next year is at risk of being dramatically reduced/cut. If you like the OSR please consider signing/sharing this petition! chng.it/yjs4Bnyf9s
@ohbmofficial.bsky.social @ohbmossig.bsky.social