Brain and Sleep Research Laboratory

Mitochondrial origins of the pressure to sleep - Nature Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.

Mitochondrial origins of the pressure to sleep
www.nature.com/articles/s41...

Neuroendocrine circuit for sleep-dependent growth hormone release The increase in growth hormone release during sleep is driven by sleep-wake-dependent activity of stimulatory GHRH neurons and inhibitory SST neurons in the hypothalamus. The released growth hormone e...

Neuroendocrine circuit for sleep-dependent growth hormone release: Cell www.cell.com/cell/fulltex...

A time window for memory consolidation during NREM sleep revealed by cAMP oscillation Sleep is crucial for memory formation. Deng et al. find that cAMP levels in mice oscillate with a 1-min cycle during slow-wave sleep, and hippocampal activity at the peak of these oscillations is nece...

A time window for memory consolidation during NREM sleep revealed by cAMP oscillation: Neuron www.cell.com/neuron/fullt...

Increased CSF drainage by non-invasive manipulation of cervical lymphatics - Nature The outflow pathway of cerebrospinal fluid into lymph nodes in the neck and how non-invasive mechanical stimulation can enhance drainage and restore impaired outflow in aged mice are explored.

Increased CSF drainage by non-invasive manipulation of cervical lymphatics
www.nature.com/articles/s41...

The great brain clearance and dementia debate An established theory for how good sleep reduces a person’s risk of neurodegenerative disease has been called into question. The ensuing argument could have enormous consequences for the treatment of ...

The great brain clearance and dementia debate
www.nature.com/articles/d41...

Global coordination of brain activity by the breathing cycle - Nature Reviews Neuroscience Synchrony between neuronal activity and the respiratory cycle has been observed in numerous brain regions and across many species. Tort et al. discuss the mechanisms by which brain activity is modulat...

Global coordination of brain activity by the breathing cycle

www.nature.com/articles/s41...

Parallel processing of past and future memories through reactivation and synaptic plasticity mechanisms during sleep - Nature Communications Neural mechanisms underlying memory acquisition and encoding are not fully understood. Here authors show that during sleep, besides the replay of past memory, coactivity of a new set of cells arises (...

Parallel processing of past and future memories through reactivation and synaptic plasticity mechanisms during sleep

www.nature.com/articles/s41...

ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep | PNAS Metabolism plays a key role in the maintenance of sleep/wake states. Brain lactate fluctuations are a biomarker of sleep/wake transitions, where in...

ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep
www.pnas.org/doi/10.1073/...

Reversible reduction in brain myelin content upon marathon running - Nature Metabolism Using magnetic resonance imaging on marathon runners, Ramos-Cabrer, Cabrera-Zubizarreta et al. report that the signal detected as a surrogate of myelin content is significantly reduced after exercise,...

Reversible reduction in brain myelin content upon marathon running
www.nature.com/articles/s42...

Enhanced memory despite severe sleep loss in Drosophila insomniac mutants Sleep is known to support memory. In this study, the authors identify an instance where memory hyperfunction may actually provoke sleep deficits. They find that the short-sleep Drosophila mutants, ins...

Enhanced memory despite severe sleep loss in Drosophila insomniac mutants

journals.plos.org/plosbiology/...

Sleep pressure accumulates in a voltage-gated lipid peroxidation memory - Nature Sleep-inducing neurons in Drosophila rely on Hyperkinetic, the β-subunit of the KV1 channel Shaker, to monitor sleep need by translating lipid peroxidation events into changes in the oxidation state o...

Sleep pressure accumulates in a voltage-gated lipid peroxidation memory
www.nature.com/articles/s41...

Consciousness or pseudo-consciousness? A clash of two paradigms - Nature Neuroscience Integrated information theory (IIT) starts from consciousness, which is subjective, and accounts for its presence and quality in objective, testable terms. Attempts to label as ‘pseudoscientific’ a th...

Consciousness or pseudo-consciousness? A clash of two paradigms

www.nature.com/articles/s41...

Pupil size reveals arousal level fluctuations in human sleep - Nature Communications Arousal levels regulate sleep, but accurate noninvasive measures are lacking. Here, a novel method is introduced to track pupil-indexed arousal levels during human sleep, revealing pupil size changes ...

Pupil size reveals arousal level fluctuations in human sleep
www.nature.com/articles/s41...

A deep learning–enabled smart garment for accurate and versatile monitoring of sleep conditions in daily life | PNAS In wearable smart systems, continuous monitoring and accurate classification of different sleep-related conditions are critical for enhancing sleep...

A deep learning–enabled smart garment for accurate and versatile monitoring of sleep conditions in daily life
www.pnas.org/doi/10.1073/...

ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep | PNAS Metabolism plays a key role in the maintenance of sleep/wake states. Brain lactate fluctuations are a biomarker of sleep/wake transitions, where in...

Our latest in PNAS! 🎉

ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep

Take home message?

KATP channels are metabolic sensors under circadian control that gate glycolytic flux, arousal, & sleep/wake transitions.

www.pnas.org/doi/10.1073/...

Amygdalo-cortical dialogue underlies memory enhancement by emotional association How does emotion prioritize associated memory? Saito et al. show that emotional association enhances perceptual memory retention and amygdalo-cortical coordination during learning and early-NREM sleep...

Amygdalo-cortical dialogue underlies memory enhancement by emotional association: Neuron www.cell.com/neuron/fullt...

Rocking during sleep reduces motor deficits and beta-amyloid levels in an Alzheimer’s mouse model Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline, beta-amyloid plaques, and tau tangles. Growing evidence suggests a strong link between sleep disturbances a...

Rocking during sleep reduces motor deficits and beta-amyloid levels in an Alzheimer’s mouse model: iScience www.cell.com/iscience/ful...

Mechanosensation of the heart and gut elicits hypometabolism and vigilance in mice - Nature Metabolism Scott, Tan et al. characterize the neural circuits that link mechanic stimuli in the heart and gut with whole-body energy homeostasis and vigilance.

Mechanosensation of the heart and gut elicits hypometabolism and vigilance in mice
www.nature.com/articles/s42...

Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep As the brain transitions from wakefulness to sleep, processing of external information diminishes while restorative processes, such as glymphatic remo…

Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep

www.sciencedirect.com/science/arti...

Individualized temporal patterns drive human sleep spindle timing

www.pnas.org/doi/10.1073/...

Memory control deficits in the sleep-deprived human brain | PNAS Sleep disturbances are associated with intrusive memories, but the neurocognitive mechanisms underpinning this relationship are poorly understood. ...

Memory control deficits in the sleep-deprived human brain

www.pnas.org/doi/10.1073/...

Sleep microstructure organizes memory replay - Nature The temporal microstructure of the brain can multiplex distinct cognitive processes during sleep to support continuous learning.

Sleep microstructure organizes memory replay

www.nature.com/articles/s41...

Pioneering journal eLife faces major test after loss of impact factor The open-access title’s bold publishing model has bought long-bubbling conflicts to the fore.

Pioneering journal eLife faces major test after loss of impact factor

www.nature.com/articles/d41...

The unbearable slowness of being: Why do we live at 10 bits/s? Zheng and Meister write about the paradoxical slowness of human behavior. Although our senses gather data at 109 bits/s, our overall information throughput is only 10 bits/s. This stark contrast touches on many fundamental aspects of brain function.

The unbearable slowness of being: Why do we live at 10 bits/s

www.cell.com/neuron/abstr...

Breathing orchestrates synchronization of sleep oscillations in the human hippocampus

www.pnas.org/doi/10.1073/...

Interested in studying #sleep closed-loop acoustic stimulation applications in #epilepsy? We have 1 #postdoc position for you! Deadline Jan 10th. Starting in Feb2025.

@UniCamerino

Pls share! #JobAlert #ResearchCareers #PostdocJobs

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Membrane potential states gate synaptic consolidation in human neocortical tissue - Nature Communications Whether and how slow wave activity (SWA) and the underlying membrane potential UP and DOWN states initiate mechanisms that augment memory functions in humans are not fully understood. Here authors use...

Membrane potential states gate synaptic consolidation in human neocortical tissue

www.nature.com/articles/s41...

Microglia as hunters or gatherers of brain synapses - Nature Neuroscience How microglia sculpt brain circuits is not clear. Here, the authors propose that their contribution to synapse removal may occur by severing synapses (culling) or collecting synapses shed off by neuro...

Microglia as hunters or gatherers of brain synapses

www.nature.com/articles/s41...

Macrophage-mediated myelin recycling fuels brain cancer malignancy Recycling of cholesterol-rich myelin debris by macrophages leads to the emergence of lipid-laden macrophages (LLMs) in glioblastoma. LLMs support glioblastoma malignancy through transfer of myelin-derived lipids to tumor cells, fueling cancer cell proliferation and recurrence.

Macrophage-mediated myelin recycling fuels brain cancer malignancy

www.cell.com/cell/fulltex...

The Infraslow Fluctuation of Sigma Power During Sleep: Links to Markers of Arousal and Memory Reactivation Across Development Sleep is both a state of disconnection from the environment and a critical period for restoration. But how does sleep balance responsiveness with the protection of key functions? The infraslow fluctua...

The Infraslow Fluctuation of Sigma Power During Sleep: Links to Markers of Arousal and Memory Reactivation Across Development
www.biorxiv.org/content/10.1...