Eric Chevet

Trumpisation de l’Université et fichage politique Ce billet est consacré aux différentes facettes de l’offensive trumpiste du ministre en charge de l’Enseignement supérieur et de la recherche : nous dévoilons un questionnaire de fichage politique …

Le pdf du sondage + un décorticage par les chercheurs est disponible chez @rogueesr.bsky.social :

rogueesr.fr/trumpisation...

Trumpisation de l’Université et fichage politique Ce billet est consacré aux différentes facettes de l’offensive trumpiste du ministre en charge de l’Enseignement supérieur et de la recherche : nous dévoilons un questionnaire de fichage politique …

Aucune idée pour l'accès du questionnaire de base, mais il y en a une copie consultable dans l'article dédié de @rogueesr.bsky.social : rogueesr.fr/trumpisation...

Le pire n’est pas certain « Le pire n’est pas certain. Et s’il survient, il peut être combattu. Et une nouvelle fois repoussé. » Robert Birenbaum, Résistant, est décédé le 22 novembre 2025. Que la terre lui soit légère. Sém…

Billet du 30 Novembre. Le pire n’est pas certain.

> Politique des Sciences du 3 décembre sur l'IA, la recherche et l'enseignement
> This survey is closed. Thank you
> Les rouages de l’antisémitisme, du racisme, du sexisme et des haines sociales
> Décliner son identité

rogueesr.fr/le-pire-nest...

The epitranscriptome formed by the growing number of modifications occurring within mRNA transcripts.

We have been mapping mRNA modifications for over a decade.

=> Characterizing their functions -- especially on translation -- is a research frontier.

Just one week away until #CellBio2025!

Please plan to join us for a sUPeR speakER lineup at the #EndoplasmicReticulum Minisymposium!

Dec 10 at 9 AM

@ascbiology.bsky.social

a black and white photo of a woman wearing glasses speaking into a microphone ALT: a black and white photo of a woman wearing glasses speaking into a microphone

It's here! This week's summary of novel computational and analytical methods for #metabolomics and #lipidomics

biomed.news/bims-metlip/...

A collaboration with @biomednews.bsky.social

Useful insights from this nice, expert 'community comment' @natcomms.nature.com Biomolecular condensates aren’t just LLPS, or oil-and-water droplets. They span diverse material states and interactions. Nuanced, precise terms help capture this complex physics and move the field forward.
rdcu.be/eSnXW

This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social --https://biomed.news/bims-proteo/2025-11-30
Highlight: Defining the role of β-cell IRE1α/XBP1 and its gene regulatory network components in non-obese diabetic mice www.nature.com/articles/s41...

This is circulating on fb and was sent to me to post!

Ignorance on MAGA’s part plays right into and is the main reason the orange pile of 💩 is still around.

Anyone believing this garbage is more dumb than the 💩 🍊 plague himself!

Well said! We already have too many A-rated excellent ERC projects that can’t be funded. Same for MSCA!

imagine that this will go to a PI in a core funded institute with already constant income of funds..how likely is this going to be?!

« Vingt jours de prison et Nicolas Sarkozy en fait un livre. C’est comme si je sortais un essai féministe parce que j’ai vidé le lave-vaisselle » Dans sa chronique, Guillemette Faure met en lumière les transformations invisibles de notre époque. Cette semaine, l’essor des livres express, à l’instar de celui écrit par l’ancien président de la République sur son séjour à la Santé, qui paraîtra un mois seulement après sa libération.

« Vingt jours de prison et Nicolas Sarkozy en fait un livre. C’est comme si je sortais un essai féministe parce que j’ai vidé le lave-vaisselle »

ERC success rates are tanking and the move is... even bigger grants for fewer people? smh

Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis Wang et al. identify a new lytic cell death pathway, mitoxyperilysis, triggered by the synergy of innate immune activation and metabolic stress. This process is regulated by mTORC2 and involves persistent mitochondria-membrane contact, leading to localized oxidative damage and cell lysis, with implications for inflammatory diseases and cancer therapy.

Now online! Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis

Microscopy preprints – new tools and techniques in imaging - FocalPlane Microscopy preprints – new tools and techniques in imaging - News

📢Our latest #preprint list is now up on FocalPlane

This week we highlight the latest tools and techniques in microscopy. Drop us a note if we’ve missed a preprint that you’ve enjoyed reading.
focalplane.biologists.com/2025/11/28/m...

🧬🛡️How are new immune mechanisms created?

We show how Lamassu antiphage system, originated from a DNA-repair complex and evolved into a compact and modular immune machine, wt Dinshaw Patel lab in @pnas.org.
👏 @matthieu-haudiquet.bsky.social, Arpita Chakravarti & all authors!

doi.org/10.1073/pnas...

And the saga continues! Our collaborative work with outstanding Justin Korfhage & Thomas Melia’s lab in PNAS shows that ATG2A transfers triglycerides and does so bidirectionally! An exciting twist in our understanding of lipid transport.
Definitely worth a deep read:
www.pnas.org/doi/10.1073/...

New online: ATG2A–DGAT2 cooperation fuels lipid droplet growth

Anthony A. Hyman will become EMBL’s next Director General.

He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.

www.embl.org/news/people-...

Why, Nature, really?

Because we're always right! Every husband knows

Ferroptosis induced by inhibition of GPX4 suppressed tumor growth in 2D, but not in 3D or in vivo. Lipids are different

"Lipid Composition Alters Ferroptosis Sensitivity" aacrjournals.org/cancerres/ar...

Mannose trimming is the dominant signal for the release of misfolded glycoproteins from ER quality control N-glycosylation is essential for protein folding in the endoplasmic reticulum (ER). Glycan attachment facilitates the binding of newly synthesized pol…

#ER_literature Mannose trimming is the dominant signal for the release of misfolded glycoproteins from ER quality control www.sciencedirect.com/science/arti...

Mid-career Group Leader position in AI in genomics at Institut Pasteur, Paris - Research Institut Pasteur and the CNRS are launching a call for a mid-career group leader position in AI in genomics. We are looking for an experienced researcher (typically with > 8 years of research experien...

There a is a joint call between @pasteur.fr and @cnrsbiologie.bsky.social for a mid career group leader position in AI and genomics (or molecular biology). Don't hesistate to spread the word if you know anyone relevant.

research.pasteur.fr/en/call/mid-...

Defining the role of β-cell IRE1α/XBP1 pathway and its gene regulatory network components in non-obese diabetic mice - Nature Communications Modulating the unfolded protein response (UPR) can induce protective dedifferentiation of β-cells in non-obese diabetic mice. Here, the authors show that β-cell deletion of UPR transcription factor XB...

Here deletion of Xbp1 in β-cells (Xbp1β-/-) of non-obese diabetic mice before insulitis is protective against #diabetes
www.nature.com/articles/s41...

Exciting collaboration with @saezlab.bsky.social @ebi.embl.org Tamas Korcsmaros @imperialcollegeldn.bsky.social and @opentargets.org

Postdoctoral fellow - Petsalaki Group - NetworkCommons Your group The Petsalaki, Saez-Rodriguez (EMBL-EBI) and Korcsmáros (Imperial College) groups develop cutting-edge computational and AI approaches to unravel cellular signalling and gene regulation fro...

#Postdoc alert! We are looking for motivated individual with experience in computational systems biology to join our NetworkCommons initiative to benchmark and democratise network contextualisation methods across multiple applications. Deadline Dec 17th link here: tinyurl.com/yrrzxa94

#ER_literature

Defining the role of β-cell IRE1α/XBP1 pathway and its gene regulatory network components in non-obese diabetic mice - Nature Communications Modulating the unfolded protein response (UPR) can induce protective dedifferentiation of β-cells in non-obese diabetic mice. Here, the authors show that β-cell deletion of UPR transcription factor XB...

Our new paper is out now in Nature Communications! We uncovered the function of XBP1 in beta cells of a preclinical model of T1D and identified unique and shared gene regulatory networks driven by IRE1 and XBP1.

www.nature.com/articles/s41...

JCS @jcellsci.bsky.social - strong reputation, true non-profit, run by working scientists, free to publish, and they even plant a tree for every paper you publish.

I am begging people to *please* stop using these tools to make a point or make fun of them. We do not need to further refine them or kill the planet to make a point. We should stop using them to make them irrelevant.