Colistin monotherapy versus colistin combination therapy in the treatment of patients with multidrug-resistant (MDR) and extensively drug-resistant (XDR) Acinetobacter baumannii infections: a meta-analysis
Matthew E Falagas, et al.
Journal of Hospital Infection, 2025.
DOI: 10.1016/j.jhin.2025.10.019
31.10.2025 07:19 โ ๐ 0 ๐ 0 ๐ฌ 0 ๐ 0
Development and Validation of the SOFA-2 Score
This article describes the data-driven development and validation of the final SOFA-2 score.
Development and Validation of the Sequential Organ Failure Assessment (SOFA)-2 Score.
Ranzani OT, Singer M, Salluh JIF, et al.
JAMA. Published online October 29, 2025. jamanetwork.com/journals/jam...
29.10.2025 15:55 โ ๐ 1 ๐ 1 ๐ฌ 0 ๐ 0
Neurological Manifestations of SARS-CoV-2
Jasmine Miftahof, et al.
Viruses 2025, 17(11), 1432
doi.org/10.3390/v171...
29.10.2025 07:06 โ ๐ 0 ๐ 0 ๐ฌ 0 ๐ 0
Antagonistic in vitro interaction between olorofim and voriconazole against Aspergillus fumigatus
AbstractBackground and objectives. The emergence of azole resistance among Aspergillus fumigatus isolates has driven the development of novel antifungal co
Antagonistic in vitro interaction between olorofim and voriconazole against Aspergillus fumigatus
Illan Laloum, Anne-Laure Bidaud, Elise Recalt, Patrick Schwarz, Marie-Elisabeth Bougnoux, Eric Dannaoui
Journal of Antimicrobial Chemotherapy, dkaf393, doi.org/10.1093/jac/...
27.10.2025 19:09 โ ๐ 0 ๐ 0 ๐ฌ 0 ๐ 0
26.10.2025 20:43 โ ๐ 0 ๐ 0 ๐ฌ 0 ๐ 0
European Respiratory Society Clinical Practice Guideline for the Management of Adult Bronchiectasis
BackgroundBronchiectasis is a common lung condition associated with wide range of infectious, immunological, autoimmune, allergic and genetic conditions. Exacerbations and daily symptoms have the largest impact on patients and healthcare systems, and they are the key focus of treatments. Current practice is heterogeneous globally, and bronchiectasis has historically been a neglected disease. Here, we present evidence-based international guidelines for the management of adults with bronchiectasis.MethodsA European Respiratory Society (ERS) Task Force, comprising global experts, a methodologist, and patient representatives, developed clinical practice guidelines in accordance with ERS methodology and the GRADE (Grading of Recommendations, Assessment, Development and Evaluations) approach. Systematic literature searches, data extraction, and meta-analysis were performed to generate evidence tables, and recommendations were formulated using the evidence-to-decision framework. A total of 8 PICO (Patient, Intervention, Comparator, Outcomes) questions and 3 narrative questions were developed.RecommendationsThe Task Force recommendations include strong recommendations in favour of airway clearance techniques for most patients with bronchiectasis and pulmonary rehabilitation for those with impaired exercise capacity. We issue a strong recommendation for the use of long-term macrolide treatment for patients at high risk of exacerbations and a strong recommendation in favour of long-term inhaled antibiotics in patients with chronic Pseudomonas aeruginosa infection at high risk of exacerbation. Conditional recommendations support the use of eradication treatment or mucoactive drugs in specific circumstances. We suggest not to routinely use long term oral, non-macrolide antibiotic treatment or inhaled corticosteroids. Additional guidance is also provided on testing for underlying causes, managing exacerbations, and managing the deteriorating patient.ConclusionThe ERS bronchiectasis guidelines provide an evidence-based framework for optimal management of adults with bronchiectasis and serve as a benchmark for evaluating the quality of care.Scope and objectivesThe European Respiratory Society (ERS) guidelines for the management of bronchiectasis in adults provide evidence-based recommendations for the care of people with clinically significant bronchiectasis, defined by the presence of permanent dilatation of the bronchi evident on chest CT scan, along with characteristic clinical symptoms. [1] These guidelines are intended for all healthcare professionals involved in the care of adults with bronchiectasis, as well as for policymakers, regulatory authorities, and pharmaceutical companies. Bronchiectasis is a complex and heterogeneous disease; therefore, no guideline can be entirely comprehensive or replace clinical judgement. All guideline recommendations must be interpreted within the specific clinical context in which they are applied. Separate ERS guidelines for the management of bronchiectasis in children exist [2]. Bronchiectasis due to cystic fibrosis (CF) has a distinct evidence base; therefore, guidance for the management of CF is provided elsewhere. [3] Some bronchiectasis-associated conditions also have distinct guidelines for investigation and management, such as primary ciliary dyskinesia (PCD) [4], allergic bronchopulmonary aspergillosis (ABPA) [5] and non-tuberculous mycobacterial (NTM) pulmonary disease [6]. While the present guidelines apply for these conditions, they should be interpreted in conjunction with the relevant syndrome-specific recommendations.
European Respiratory Society Clinical Practice Guideline for the Management of Adult Bronchiectasis.
Chalmers JD, Haworth CS, Flume P, et al.
Eur Respir J 2025
doi.org/10.1183/1399...
25.10.2025 15:57 โ ๐ 0 ๐ 0 ๐ฌ 0 ๐ 0
Long-Term Macrolides in Chronic Respiratory Diseases: Dusk or a New Dawn? A Narrative Review
Daniele Previtero, et al.
Antibiotics 2025, 14(11), 1061;
doi.org/10.3390/anti...
23.10.2025 14:54 โ ๐ 0 ๐ 0 ๐ฌ 0 ๐ 0
Redirecting
Efficacy and Safety of Novel ฮฒ-Lactam/ฮฒ-Lactamase Inhibitor Combinations for the Treatment of Complicated Urinary Tract Infections or Acute Pyelonephritis: A Systematic review and Meta-Analysis
Sirui Tang, et al.
Journal of Global Antimicrobial Resistance, 2025
doi.org/10.1016/j.jg...
22.10.2025 16:28 โ ๐ 0 ๐ 0 ๐ฌ 0 ๐ 0
Resistance of Acinetobacter baumannii Complex Clinical Isolates to SulbactamโDurlobactam: A Systematic Review of Data from In Vitro Studies
Matthew E. Falagas, Laura T. Romanos, Dimitrios Ragias and Charalampos Filippou
Pathogens 2025, 14(10), 1062; doi.org/10.3390/path...
20.10.2025 17:58 โ ๐ 0 ๐ 0 ๐ฌ 0 ๐ 0
Antibiotic Cards โ ALLIANCE FOR THE PRUDENT USE OF ANTIBIOTICS
"Antibiotic cards" provide a summary of the main characteristics of selected antibiotics. These antibiotic cards have been primarily designed to assist the prescribers in the selection of the most app...
๐ง ๐ Free Antibiotic Summary Cards from ISAC & APUA!
Quick reference for:
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Designed by experts.
๐ apua.org/antibiotic-c...
More coming soon!
#AntibioticStewardship #APUA #ISAC #MedX
@souhakanj.bsky.social @heiman-wertheim.bsky.social
16.10.2025 10:45 โ ๐ 2 ๐ 2 ๐ฌ 0 ๐ 0
Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!! formatmypaper.com
15.10.2025 06:33 โ ๐ 444 ๐ 141 ๐ฌ 16 ๐ 39
Group Leader - DataHealth Lab
Global Health | Epidemiology | RCTs
Critical Care, Infections, Climate Change
#DecolonizeGH ๐ง๐ท
At IR Sant Pau, Barcelona / USP, Sรฃo Paulo
https://datahealthlab.org
Virus origins/diversity/evolution; mobilome; Archaea.
Head of the Archaeal Virology Unit at Institut Pasteur:
https://research.pasteur.fr/en/team/archaeal-virology/
Posting from the poison garden about toxic flora, fauna, and fungi.
https://thepoisongarden.com
Infectious Disease doc and clinical researcher; runner, biker, liberal, gardener, hiker, and canoer. Professor @U of MN; Minneapolis VA ID. All posts my own. #BLM #abolishbillionaires
Nature Medicine is a research journal devoted to publishing the latest advances in translational and clinical research for scientists and physicians.
www.nature.com/nm
Exploring the wonders of microbiology with reviews and commentaries from across the field. Brought to you by your curious editors! ๐ฌโจ
https://nature.com/nrmicro/
Scripps Research is one of the world's largest, private, non-profit biomedical research organizations. We are Science Changing Life.
Associate professor ๐ฉ๐ปโ๐ซ , ID translational research, pharmacist educator, MDR GNR enthusiast ๐งซ, UTI, MN.
โก๏ธSlow runner ๐๐ปโโ๏ธ, Swiftie ๐๐ชฉ.
#BLM #SauceForMason #PharmGradWishlist #IDSky #PharmSky #UTISky #MedSky
Professor of Medicine, McMaster University
Executive Director of the Firestone Institute for Respiratory Health
Board of Directors Lung Health Foundation
#macrophages #aging #respiratoryinfections #vaccinations #immunity #inflammation #scicomm
Sarah Cannon Research Institute (SCRI) is one of the worldโs leading oncology research organizations conducting community-based clinical trials. Focused on advancing therapies for patients over the last three decades, SCRI is a leader in drug development.
The European Association for the Study of Obesity represents 40 European nations dedicated to understanding and addressing obesity to improve public health.
Prof (CS @Stanford), Co-Director @StanfordHAI, Cofounder/CEO @theworldlabs, CoFounder @ai4allorg #AI #computervision #robotics #AI-healthcare
Meet new people
Microbiology Society: A world in which the science of #microbiology provides maximum benefit to society | microbiologysociety.org
lnk.bio/microbiosoc
Relaying microbiology news, articles and comments relevant to aspects on bacteria, fungi, viruses and other microbes / microorganisms. Microbes are ๐ช
Making games to teach & learn antibiotics, microbiology, and (soon) infectious disease epidemiology! Also sharing any good ID memes and infographics I find in the process...
https://labbeaglegames.com/
Scientific Advisor at Broad Institute of MIT & Harvard ๐งฌ Co-author of VIRAL: The Search for the Origin of Covid-19 ๐ A dangerous young investigator ๐ต๐ปโโ
Infectious Diseases physician, clinical researcher - clinical trials, SAB, PJI, sepsis, viral hep. CI of SNAP and ROADMAP trials. Runner, Novocastrian, Dad (and thus Dad jokes ++), Chocoholic
#IDSky #SNAPtrial
Cellular microbiologist, #UTI host/pathogen interactions, lab head at University College London, novelist, broadcaster, writer, pundit, sci comm, musician, gardener, Editor of LabLit.com, all things geek-chic. M7HZT on ham radio. More at jennyrohn.com
