Stuart O'Connor

Chronic stress drives depression by disrupting cellular housekeeping Boosting the recycling process known as autophagy — impaired in the brain during prolonged stress — has the potential to restore normal neuronal activity and treat depression.

Chronic stress, impaired autophagy, and depression (as opposed to acute stress)
www.nature.com/articles/d41...

10.04.2025 14:34 — 👍 171    🔁 37    💬 4    📌 4

Imamura and Kelz discuss the neuropharmacology of orexin/hypocretin signaling and its potential to meaningfully impact clinical care. Read the new editorial: ow.ly/f85p50VfCXT

13.03.2025 19:55 — 👍 1    🔁 1    💬 0    📌 0

Man survives with titanium heart for 100 days – a world first The device, to be tested in more people, could be used as a temporary measure for those waiting for a donor organ.

An Australian man in his forties has become the first person in the world to leave hospital with an artificial heart made of titanium

The device could be a temporary measure for those waiting for a donor organ

https://go.nature.com/3FCPcFn

13.03.2025 13:08 — 👍 81    🔁 14    💬 0    📌 2

Jet Ventilation

My latest #BJAEd podcast discussing Jet Ventilation with Dr Craig Lyons is available now:

12.03.2025 16:04 — 👍 1    🔁 0    💬 0    📌 0

Who’s likely to wake up from a coma? Brain waves provide a clue The presence of a pattern called a sleep spindle helps to predict which people will recover from an unresponsive state.

The presence of a pattern called a sleep spindle helps to predict which people will recover from an unresponsive state

https://go.nature.com/3Dt9WPn

10.03.2025 15:20 — 👍 49    🔁 7    💬 1    📌 0

‘Slime’ keeps the brain safe ― and could guard against ageing Slippery proteins in the brain’s blood vessels form a protective barrier that breaks down with age, studies in mice show.

Slippery proteins in the brain’s blood vessels form a protective barrier that breaks down with age

https://go.nature.com/4kjeHf2

27.02.2025 10:32 — 👍 82    🔁 18    💬 2    📌 2

Rare genetic disorder treated in womb for the first time The child, who is now almost three years old, shows no signs of the often fatal motor neuron disease.

A two-and-a-half-year-old girl shows no signs of a rare genetic disorder, after becoming the first person to be treated for the motor-neuron condition while in the womb.

https://go.nature.com/41a7Zzj

20.02.2025 11:17 — 👍 372    🔁 111    💬 5    📌 29