Stuart O'Connor

Chronic stress drives depression by disrupting cellular housekeeping Boosting the recycling process known as autophagy — impaired in the brain during prolonged stress — has the potential to restore normal neuronal activity and treat depression.

Chronic stress, impaired autophagy, and depression (as opposed to acute stress)
www.nature.com/articles/d41...

Imamura and Kelz discuss the neuropharmacology of orexin/hypocretin signaling and its potential to meaningfully impact clinical care. Read the new editorial: ow.ly/f85p50VfCXT

Man survives with titanium heart for 100 days – a world first The device, to be tested in more people, could be used as a temporary measure for those waiting for a donor organ.

An Australian man in his forties has become the first person in the world to leave hospital with an artificial heart made of titanium

The device could be a temporary measure for those waiting for a donor organ

https://go.nature.com/3FCPcFn

Jet Ventilation

My latest #BJAEd podcast discussing Jet Ventilation with Dr Craig Lyons is available now:

Who’s likely to wake up from a coma? Brain waves provide a clue The presence of a pattern called a sleep spindle helps to predict which people will recover from an unresponsive state.

The presence of a pattern called a sleep spindle helps to predict which people will recover from an unresponsive state

https://go.nature.com/3Dt9WPn

‘Slime’ keeps the brain safe ― and could guard against ageing Slippery proteins in the brain’s blood vessels form a protective barrier that breaks down with age, studies in mice show.

Slippery proteins in the brain’s blood vessels form a protective barrier that breaks down with age

https://go.nature.com/4kjeHf2

Rare genetic disorder treated in womb for the first time The child, who is now almost three years old, shows no signs of the often fatal motor neuron disease.

A two-and-a-half-year-old girl shows no signs of a rare genetic disorder, after becoming the first person to be treated for the motor-neuron condition while in the womb.

https://go.nature.com/41a7Zzj