Andy Bell

A molecular map of the human spinal dorsal and ventral horn defines arrangement of neuronal types and glial sex differences The spinal cord is the gateway for sensory information from the body as it ascends to the brain, as well as a major motor output center of the nervous system. It is also a key location for sensory-mot...

Thrilled to share our latest preprint using single nuq sequencing and Xenium to define neuron organisation and sex differences in glia within human spinal cord. Truly a collaborative effort, with a big shoutout to Katherin Gabriel and @tedpricethepainguy.bsky.social

www.biorxiv.org/content/10.1...

01.11.2025 10:46 — 👍 32    🔁 11    💬 3    📌 0

Characterisation of cold-selective lamina I spinal projection neurons Skin cooling is detected by primary afferents that express the Trpm8 channel, but how this information is conveyed to the brain remains poorly understood. We have previously identified a population of...

www.biorxiv.org/content/10.1...

04.10.2025 08:38 — 👍 3    🔁 0    💬 0    📌 0

Labelled axons of calb1+ spinal projection neurons innervate multiple brain targets associated with cold sensation and thermoregulation. Darkfield images of different brain areas including the postal parabrachial and periaqueductal grey are shown with axons of ascending cells in yellow.

New preprint from the spinal cord group at Glasgow. Anatomical and functional characterisation of spinal circuits for cold, from sensory neurons to the brain…..https://www.biorxiv.org/content/10.1101/2025.10.03.680240v1

04.10.2025 08:34 — 👍 23    🔁 8    💬 2    📌 0

Research Associate RESEARCH ASSOCIATECOLLEGE OF MVLSSCHOOL OF PSYCHOLOGY & NEUROSCIENCE GRADE 7 We are looking for an enthusiastic Research Associate to employ RNA sequencing and spatial transcriptomics in combin...

Are you interested in omics approaches to pain and projection neurons? Why not join us? We’ve got a post-doc position available. Happy to discuss further with anyone who is interested. www.jobs.gla.ac.uk/job/research...
#neuroskyence #neurosci #PainResearch

02.07.2025 15:19 — 👍 6    🔁 7    💬 0    📌 1

Check out my postdoc work at Ariel Levine’s lab, hot and fresh, describing how you build a dorsal horn!

www.biorxiv.org/content/10.1...

17.03.2025 16:16 — 👍 43    🔁 14    💬 1    📌 2

Here’s a great opportunity for someone…..

17.01.2025 09:57 — 👍 0    🔁 0    💬 0    📌 0

Cells of the mouse dorsal root ganglion. Cold sensing sensory neurons are small cells and are stained with HCR in situ hybridisation probes against TRPM8 mRNA

It's #fluorescencefriday so here are some lovely TRMP8-expressing cold-sensing sensory neurons in a mouse DRG. DAPI nuclei in green and TRPM8 mRNA in magenta.

10.01.2025 16:10 — 👍 15    🔁 1    💬 0    📌 0

1/ 🧠 Excited to share our new preprint:

Convergent state-control of endogenous opioid analgesia

We uncover how cognitive + contextual factors—like injury, fear, and placebo—modulate pain through dynamic opioid signaling in the periaqueductal gray (PAG)

biorxiv.org/content/10.1...

04.01.2025 17:24 — 👍 55    🔁 23    💬 4    📌 5

Hi Ted. Great idea. Could you add me please?

21.11.2024 19:40 — 👍 1    🔁 0    💬 0    📌 0

Anatomical characterisation of somatostatin-expressing neurons belonging to the anterolateral system Anterolateral system (ALS) spinal projection neurons are essential for pain perception. However, these cells are heterogeneous, and there has been extensive debate about the roles of ALS populations i...

Seems like a good idea to move over to here! What better way to start than our new preprint.... Anatomy of a fascinating molecularly defined subset of spinal projection neurons......
www.biorxiv.org/content/10.1...

21.11.2024 14:27 — 👍 27    🔁 6    💬 2    📌 1