Paul Glasziou

Ah Ha! The secret system experts use for creating #overdiagnosis ;-)

YouTube video by The Accelerator of Evidence Using the Evidence Review Accelerator (TERA)

Friday tip for fast reviews. Our "2weekSR" process uses automated tools (see tera-tools.com): ReviewWizard (protocol), SearchRefiner, PolyGlot (translate to multiple databases), Screenatron (&Mechatron for AI-assist), SpiderCite (forward&backward), ... video overview:
www.youtube.com/watch?v=ghW_...

#CochraneDaily Read reflections from Andy Oxman, Iain Chalmers and Paul Glasziou on the long and winding road of promoting informed health choices in this new James Lind Library article👇
www.jameslindlibrary.org/articles/pro...

@jameslindlibrary.bsky.social @cochrane.org @paulglasziou.bsky.social

Sadly yes - a variant of Brandolini’s Law “The amount of energy needed to refute bullshit is an order of magnitude bigger than that needed to produce it.” en.wikipedia.org/wiki/Brandol...

Paracetamol use during pregnancy not linked to autism, our study of 2.5 million children shows Our research provides strong evidence against the concerning claims made recently by US president Donald Trump.

Acetaminophen (aka Paracetamol/Tylenol) NOT linked to autism: Swedish study followed nearly 2.5 million children born between 1995 and 2019, tracking them for up to 26 years. Analyses included pairs of siblings with/without exposure theconversation.com/paracetamol-...

How to Communicate Medical Numbers This JAMA Insights provides evidence-based recommendations for communicating numerical information to patients.

How to Communicate Medical Numbers

The effectiveness of sharing numerical information depends on patients’ ability to understand and interpret these numbers. Understanding numbers may be difficult for patients with limited numeracy skills.

jamanetwork.com/journals/jam...

Prove It by Elizabeth Finkel A compelling journey through science's big breakthroughs, by an award-winning Australian science writer

Elizabeth Finkel is the author of a recent & very readable book on scientific method(s): www.blackincbooks.com.au/books/prove-it

Friday essay: Trump and Kennedy are destroying global science. Even Einstein questioned facts – but there’s a method to it Modern science emerged precisely to deal with the way everything can be manipulated – and scepticism over ‘facts’ goes all the way back to Socrates.

“Our health, our agriculture, our environmental safety, our ability to ameliorate and adapt to climate change, to regulate AI and to fight the next pandemic, all rely on the proper functioning of the scientific machine. We must not stand by and see it dismantled.” theconversation.com/friday-essay...

Electricity generation costs would be up to 50% higher if Australia stuck with coal and gas only Griffith University experts reveal the 30% increase in consumer power bills since 2021 would have been worse under fossil fuel-only scenario

Electricity generation costs would be up to 50% higher if #Australia stuck with #coal and #gas only.
www.theguardian.com/australia-ne...

Antiscience Is an Existential Threat The ideologically-motivated assault on science threatens us all.

"Antiscience Is an Existential Threat" | My op-ed with @peterhotezmdphd.bsky.social for #TimeMagazine on our new book, #ScienceUnderSiege: time.com/7317436/scie...

It doesn’t matter if you’re working class or a billionaire: climate change will hurt your grandchildren.

That’s why I cannot understand oil executives who sacrifice the planet’s health for their short-term profits

We must transform our energy system away from fossil fuels NOW.

Not ambitious enough; but good to see specific resource allocation: a C+ “The Albanese government has finally set a 2035 climate course – and it’s a mission Australia must accept” theconversation.com/the-albanese...

257. The Commission recommends that all Member States: (a) Employ all means reasonably available to them to prevent the commission of genocide in the Gaza Strip; (b) Cease the transfer of arms and other equipment or items, including jet fuel, to the State of Israel or third States where there is reason to suspect their use in military operations that have involved or could involve the commission of genocide; (c) Ensure individuals and corporations in their territories and within their jurisdiction are not involved in the commission of genocide, aiding and assisting the commission of genocide or incitement to commit genocide and investigate and prosecute those who may be implicated in these crimes under international law; (d) Facilitate the investigations and domestic proceedings and take action (including imposing sanctions) against the State of Israel and against individuals or corporations that are involved in or facilitating the commission of genocide or incitement to commit genocide; (e) Cooperate with the investigation of the Office of the Prosecutor of the International Criminal Court. 258. The Commission recommends that the Prosecutor of the International Criminal Court: (a) Examine, within its continuing investigation in the Situation in the State of Palestine, the crime of genocide for amendment to existing arrest warrants and addition to future application for arrest warrants; (b) Examine the involvement of officials mentioned in this report for inclusion as those most responsible for international crimes committed in the occupied Palestinian territory.

Today, the UN officially designated Israel’s assault on Gaza as a genocide.

As a party to the Genocide Convention, the U.S. has a legal obligation to obey our own laws, stop weapons sales to Israel, and demand a permanent ceasefire.

End the genocide. Ceasefire now.

A new review of multicancer early detection tests (MCED). Without any controlled studies in people without symptoms (and at increased risk), they are "not ready for popular use." @annalsofim.bsky.social
www.acpjournals.org/doi/10.7326/...
www.acpjournals.org/doi/epdf/10....

Is this Australia’s climate wake-up call? Official report reveals a hotter, harder future if we don’t act now The sobering assessment is a national call to action. The sooner Australia mitigates and adapts, the safer we will be.

Is this Australia’s climate wake-up call? Official report reveals a hotter, harder future if we don’t act now @theconversation.com theconversation.com/is-this-aust...

Very helpful Substack article for making some sense of the diverse MAGA “factions” and their overlap & conflicting ideologies, especially Christian Nationalist cf atheist Tech Bros - thanks @asharangappa.bsky.social

Fascinating article. One amusing error -> “when researchers asked state-of-the-art models for the birthday of Adam Kalai, one of the paper’s authors, DeepSeek-V3 confidently provided three different incorrect dates across separate attempts: “03-07”, “15-06”, and “01-01”...”

v1.108 is rolling out today 🚚

Now live, at long last: Bookmarks, aka Saved Posts. For all those posts you'll definitely plan to come back to!

Update the app and give it a try. The button is right down there 👇

Trial-based economic evaluations of non-drug interventions in the Royal Australian College of General Practitioners (RACGP) Handbook of Non-Drug Interventions in primary care: a systemic review - PubM... Most of the HANDI NDIs that were included within this systematic review are cost-effective compared with a variety of alternatives including usual care or waiting list controls. HANDI NDIs warrant use...

Trial-based economic evaluations of non-drug interventions in the Royal Australian College of General Practitioners (RACGP) Handbook of Non-Drug Interventions: a systemic review: "of 150 NDIs, 40% were cheaper and more effective, and 70% considered cost effective." pubmed.ncbi.nlm.nih.gov/40889888/

Percent change in GHG emissions (CO2eq) per year since 1990, G7/EU.

🫣🇨🇦

If the administration releases the data for the causes-of-autism study that is supposed to be reported this month, then it could be useful to have a crowdsourced many analyst/multiverse investigation ready to go that leans-in on pre-commitment to analysis plans.

Interested? Alternatives?

YouTube video by Elle Cordova For our scientists

“For our scientists” - wonderful song by @ellecordova.bsky.social that sums up what’s happening to science in the USA youtube.com/shorts/AYm9w...

New research demonstrating a shift in online climate misinformation

Rather than denying climate science, this 'new denial' comprises "attacks that seek to undermine and cast doubt on proposed climate solutions and those who support them."

resolve.cambridge.org/core/journal...

Germany Already Met Its 2028 Goal for Reducing Coal-Fired Power Germany has already met its 2028 goal for reducing coal-fired power generation, so won’t need to order the shutdown of any plants for a second year running, the country’s regulator said.

Here's a ray of sunshine in a very dark world

Germany has already exceeded its goal of shutting down 8 GW of coal plants - 3 years earlier than expected

Amazing what a little sun and wind can do 😎

www.bloomberg.com/news/article...

The Impact of Definitions of Disease on Overdiagnosis This Viewpoint discusses the global challenge of defining diseases and the need to balance broader access to medical treatment with avoidance of harmful medicaliziation and inefficient resource use.

Viewpoint: The definition of disease is vital for clinical and public health, but broad criteria risk overdiagnosis and overtreatment ja.ma/4nbWSzg

Sometimes I wish there really was a Hell … so that Turnip & his malignant fossil-fuel buddies received their well-deserved karma. But in reality, we have to provide that hell (and support to climate activists/policy-makers).