Craig A. Goodman

Phosphatidylserine Supplementation Improves Metabolic Liver Disease and Glycemic Control in the Presence of Suppressed Oxidative Glucose Metabolism Type 2 diabetes and obesity are commonly accompanied by metabolic dysfunction–associated steatotic liver disease (MASLD), increasing the risk of developing

Phosphatidylserine Supplementation Improves Metabolic Liver Disease and Glycemic Control in the Presence of Suppressed Oxidative Glucose Metabolism
diabetesjournals.org/diabetes/art...

Big Bones Mean Big Muscles: An MRI-Based Dataset of Muscle-Bone-Body Size Relationships Across 70 Human Muscles of the Upper Limb, Trunk, and Lower Limb | Journal of Applied Physiology | American Phys... Body sizes and shapes vary widely, even among healthy adults, resulting in diverse muscle sizes, strengths, and performance capacities. This study developed an AI (artificially intelligent) algorithm ...

Big Bones Mean Big Muscles: An MRI-Based Dataset of Muscle-Bone-Body Size Relationships Across 70 Human Muscles of the Upper Limb, Trunk, and Lower Limb
journals.physiology.org/doi/abs/10.1...

Dual role of Macrophages in skeletal muscle Atrophy: Mechanisms and therapeutic strategies Skeletal muscle atrophy represents a pathological condition characterized by impaired protein homeostasis that commonly occurs with aging, chronic inf…

Dual role of Macrophages in skeletal muscle Atrophy: Mechanisms and therapeutic strategies
www.sciencedirect.com/science/arti...

Precision rewriting of muscle genetics: therapeutic horizons of base and prime editing in skeletal muscle disorders - Gene Therapy Gene Therapy - Precision rewriting of muscle genetics: therapeutic horizons of base and prime editing in skeletal muscle disorders

Precision rewriting of muscle genetics: therapeutic horizons of base and prime editing in skeletal muscle disorders
www.nature.com/articles/s41...

Autophagy cargo profiles in skeletal muscle during starvation and exercise Autophagy is a cellular process to clear unwanted and dysfunctional cellular cargoes, which are sequestered in autophagosomes before their delivery to lysosomes for degradation. Autophagy cargo sel...

Autophagy cargo profiles in skeletal muscle during starvation and exercise
www.tandfonline.com/doi/full/10....

Age-related decline of chaperone-mediated autophagy in skeletal muscle leads to progressive myopathy - Nature Metabolism Chaperone-mediated autophagy declines with age in skeletal muscle of humans and mice, leading to muscle dysfunction characterized by impaired calcium homoeostasis and mitochondrial function.

Age-related decline of chaperone-mediated
autophagy in skeletal muscle leads to
progressive myopathy
www.nature.com/articles/s42...

The CTLH ubiquitin ligase substrates ZMYND19 and MKLN1 negatively regulate mTORC1 at the lysosomal membrane - Nature Communications Here they show that the E3 ubiquitin ligase CTLH supports mTORC1. Upon CTLH inactivation, ZMYND19 and MKLN19 accumulate, associate, and block mTORC1/RHEB association. CTLH and PI3K inhibition are synt...

The CTLH ubiquitin ligase substrates ZMYND19 and MKLN1 negatively regulate mTORC1 at the lysosomal membrane
www.nature.com/articles/s41...

Tension to Translation: External to Internal Processes in Muscle Hypertrophy | Physiology | American Physiological Society Skeletal muscle is a highly adaptable tissue that plays a central role in overall health. The dynamic balance between muscle protein synthesis and breakdown governs skeletal muscle mass maintenance. I...

Tension to Translation: External to Internal Processes in Muscle Hypertrophy
journals.physiology.org/doi/abs/10.1...

Precancer exercise capacity and metabolism during tumor development coordinate the skeletal muscle–tumor metabolic competition | PNAS Higher exercise capacity and regular exercise training improve cancer prognosis at all stages of disease. However, the metabolic adaptations to aer...

Precancer exercise capacity and metabolism during tumor development coordinate the skeletal muscle-tumor metabolic competition
www.pnas.org/doi/10.1073/...

Assaying the myosin super-relaxed state across muscle types, cells and proteins for understanding muscle biology and use in drug discovery - Nature Protocols The Mant-ATP assay is a simple and accessible means for rapid quantitative assessment of the ratio of super-relaxed myosin to disordered relaxed myosin. This protocol provides a standardized methodolo...

Assaying the myosin super-relaxed state across muscle types, cells and proteins for understanding muscle biology and use in drug discovery
www.nature.com/articles/s41...

Cathepsin L as a dual-target to mitigate muscle wasting while enhancing anti-tumor efficacy of anti-PD-L1 - Nature Communications Immune checkpoint inhibitors (ICIs) are associated with side effects such as muscle wasting. Here, the authors discover that targeting cathepsin L not only suppresses ICI-induced CD8 + T cell-mediated...

Cathepsin L as a dual-target to mitigate muscle wasting while enhancing anti-tumor efficacy of anti-PD-L1
www.nature.com/articles/s41...

Lactate as a metabolic–epigenetic signal linking high-intensity interval training (HIIT) to miRNA-Centered remodeling of the skeletal muscle methylome and transcriptome Lactate, a key exercise-derived metabolite and exerkine, is increasingly recognized as a metabolic–epigenetic signal, yet whether lactate and its tran…

Lactate as a metabolic-epigenetic signal linking high-intensity interval training (HIIT) to miRNA-Centered remodeling of the skeletal muscle methylome and transcriptome
www.sciencedirect.com/science/arti...

Proteomics-based evaluation of AAV dystrophin gene therapy outcomes in mdx skeletal muscle
insight.jci.org/articles/vie...

Exercise enhances antioxidant protein levels in oxidative skeletal muscle via IL-1β | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology | American Physiological Society Nrf2 activation by sequestosome1/p62 (p62) (Ser351) phosphorylation is a pivotal signal for the exercise-mediated augmentation of antioxidant protein expression in muscle. However, the molecular mecha...

Exercise enhances antioxidant protein levels in oxidative skeletal muscle via IL-1β
journals.physiology.org/doi/abs/10.1...

Dystrophic Skeletal Muscle Phenotypes Can Be Horizontally Transferred via Fecal Microbiome Transplantations We sought to determine a causal role for the microbiota in promoting dystrophic muscle characteristics by performing intra/inter-genotype fecal microbiota transplantations (FMT) between wildtype (C57....

Dystrophic Skeletal Muscle Phenotypes Can Be Horizontally Transferred via Fecal Microbiome Transplantations
faseb.onlinelibrary.wiley.com/doi/10.1096/...

Enhancer regulator MLL4 controls skeletal muscle metabolic efficiency by limiting AMPK-mediated fuel catabolism
www.nature.com/articles/s41...

Age-Related Anabolic Resistance: Nutritional and Exercise Strategies, and Potential Relevance to Life-Long Exercisers
www.mdpi.com/2072-6643/17...

Codon-optimized human Smad7 gene therapy enhances skeletal muscle mass and function in a murine model of Duchenne muscular dystrophy - Gene Therapy Gene Therapy - Codon-optimized human Smad7 gene therapy enhances skeletal muscle mass and function in a murine model of Duchenne muscular dystrophy

Codon-optimized human Smad7 gene therapy enhances skeletal muscle mass and function in a murine model of Duchenne muscular dystrophy
www.nature.com/articles/s41...

Fiber Type and Stimulus Determine Progression of Skeletal Muscle Atrophy Background Skeletal muscle atrophy is prevalent worldwide and is a major detractor from length and quality of life. It is often diagnosed and treated as a single disorder, but the causal stimuli and p...

Fiber Type and Stimulus Determine Progression of Skeletal Muscle Atrophy
www.biorxiv.org/content/10.1...

Myostatin Exhibits an Evolutionarily Conserved Circadian Pattern in Skeletal Muscles Introduction Myostatin (MSTN), a transforming growth factor-beta (TGF-β) superfamily member, is an evolutionarily conserved negative regulator of skeletal muscle mass. Loss of MSTN commonly promotes.....

Myostatin Exhibits an Evolutionarily Conserved Circadian Pattern in Skeletal Muscles
onlinelibrary.wiley.com/doi/10.1002/...

Effect of Neuromuscular Electrical Stimulation for Older Critically Ill Patients in the ICU: A Randomized Controlled Trial
journals.lww.com/ccejournal/f...

Exercise suppresses DEAF1 to normalize mTORC1 activity and reverse muscle aging
www.pnas.org/doi/10.1073/...

Displaced myonuclei are attributable to both resident myonuclear migration and stem cell fusion during mechanical loading in adult skeletal muscle
www.biorxiv.org/content/10.1...

The Age-Dependent Resident Myonuclear Multi-Omic Response to a Skeletal Muscle Hypertrophic Stimulus
www.biorxiv.org/content/10.1...

Proteomic profiling of extracellular fluids to identify secreted proteins from muscle and fat tissues Communication between tissues or different cells within a tissue is often a result of secreted molecules such as metabolites, lipids, nucleic acids, o…

Proteomic profiling of extracellular fluids to identify secreted proteins from muscle and fat tissues
www.sciencedirect.com/science/chap...

MicroCT enables simultaneous longitudinal tracking of murine pancreatic cancer progression and cachexia
aacrjournals.org/cancerrescom...

Ubiquitin Specific Peptidase 51 Exacerbates Skeletal Muscle Injury by Enhancing APAF1‐Mediated Apoptosis and Pyroptosis In the Skeletal Muscle Injury (SMI) microenvironment, Ubiquitin Specific Peptidase 51 (USP51) expression is significantly upregulated, functional studies uncovered that USP51 interacts with and deubi...

Ubiquitin Specific Peptidase 51 Exacerbates Skeletal Muscle Injury by Enhancing APAF1-Mediated Apoptosis and Pyroptosis
faseb.onlinelibrary.wiley.com/doi/10.1096/...

Profiling muscle mass, function and molecular signalling in females aged 18–80 years and their associations with sex hormones Abstract figure legend This study mapped the trajectory of muscle ageing at the whole-body, whole-muscle and cellular level in 96 healthy females aged between 18 and 80 years old, whilst controlling ...

Profiling muscle mass, function and molecular signalling in females aged 18-80 years and their associations with sex hormones
physoc.onlinelibrary.wiley.com/doi/10.1113/...

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TGFβ-Smad3 signaling restores cell-autonomous Srsf1-mediated splicing of fibronectin in aged skeletal muscle stem cells
www.nature.com/articles/s41...