Sakamoto Lab

New PTM (lactylation) linked with #TFEB stability and increased autophagy and lysosomal activity @jcb.org

mTORC1 senses glutamine and other amino acids through GCN2 | The EMBO Journal imageimageDuring starvation, individual amino acid levels are thought to be relayed via distinct metabolic sensors, but how mTORC1 senses glutamine remains unclear. This study finds that GCN2 kinase a...

The protein kinase, GCN2 identified as the key amino acid sensor for mTORC1. @embopress.org @embojournal.org

Commentary by Researcher @itsmedipsikha.bsky.social on the emerging role of glycogen metabolism in regulating energy homeostasis in adipose tissue is out now on @natrevendo.nature.com @cbmr.science

www.nature.com/articles/s41...

Unraveling Skeletal Muscle Insulin Resistance: Molecular Mechanisms and the Restorative Role of Exercise | Circulation Research Skeletal muscle is essential for movement and maintaining energy homeostasis and is the primary tissue for insulin-stimulated glucose uptake. Skeletal muscle is composed of various cell types that hel...

Unraveling Skeletal Muscle Insulin Resistance: Molecular Mechanisms and the Restorative Role of Exercise
www.ahajournals.org/doi/10.1161/...

Targeting cardiometabolic risk in type 1 diabetes through incretin physiology People living with type 1 diabetes have significantly increased cardiovascular risk compared with the general population. Traditional risk factors include hypertension, dyslipidaemia, and obesity. How...

Among the ways for next generation GLP-1 medicines to differentiate: Efficacy, safety and outcome trials in type 1 #Diabetes www.cell.com/trends/endoc...

Sustained Weight Loss With Combined LEAP2 and Semaglutide Treatment in Mice The recent identification of liver-expressed antimicrobial peptide 2 (LEAP2) as an endogenous antagonist and inverse agonist of the growth hormone secretag

Studies in mice reveal that LEAP2 analogs have the potential to enhance the efficacy of glucagon-like peptide 1 receptor agonism and support durable #weightloss diabetesjournals.org/diabetes/art...

Altered Relaxation and Mitochondria‐Endoplasmic Reticulum Contacts Precede Major (Mal)Adaptations in Aging Skeletal Muscle and Are Prevented by Exercise Slowed relaxation and altered MERCs embody early stages of aging in muscle, and are prevented by regular exercise.

Altered Relaxation and Mitochondria-Endoplasmic Reticulum Contacts Precede Major (Mal)Adaptations in Aging Skeletal Muscle and Are Prevented by Exercise
onlinelibrary.wiley.com/doi/10.1111/...

Protagonist Enters Obesity Fray With Triple-G Pill, Eyeing 2026 Clinical Start With PN-477, Protagonist is directly going up against Eli Lilly, which is advancing retatrutide, also a triple-G agonist, in a Phase II trial.

Innovation in the #weightloss space continues with an emerging Triple G oral peptide #obesity to enter into clinical development for obesity in 2026. www.biospace.com/drug-develop...

Last week we said goodbye to Florentina, who started as a postdoc with us in early 2020. We are truly privileged for her tenacity, hardwork & diligence that helped shape our group @cbmr.science & thank her for
guiding our junior colleagues. We wish her the best for her bright future!
.

Happy to have contributed to this very interesting work ked/driven by Raid Nisr, Alison McNeilly and Graham Rena (University of Dundee). doi.org/10.1111/apha...

🔎 𝐃𝐞𝐜𝐢𝐩𝐡𝐞𝐫𝐢𝐧𝐠 𝐭𝐡𝐞 𝐆𝐈𝐏 𝐩𝐚𝐫𝐚𝐝𝐨𝐱

Why does activating the GIP receptor contribute to weight-loss, given the evidence that blocking the receptor ought to be more effective?

Prof. Jens Juul Holst outlines the evidence in Diabetes 👇

diabetesjournals.org/diabetes/art...

#GIP #GLP1 #biotech #obesity

The Use of Salt-Inducible Kinases (SIKs) Inhibitors as an Emerging Treatment for Inflammatory, Allergic, Autoimmune, Cancer, and Metabolic Diseases - PubMed The invention in this patent application relates to pyrazolo-[1,5-<i>a</i>]-pyridine derivatives represented herein as formula I and formula II. These compounds are highly active SIK inhibitors and ma...

Great reads if you're interested in learning more about Salt-Inducible Kinases #SIKs in metabolism.

pubmed.ncbi.nlm.nih.gov/40529046/
The Use of SIK Inhibitors as an Emerging Treatment...

pubmed.ncbi.nlm.nih.gov/40384110/
Salt-inducible Kinase Regulation of Adipose Tissue Metabolism

miR-30a is a critical regulator of adipose tissue fibrosis that predicts metabolically healthy #obesity in people and mice @jclinical-invest.bsky.social www.jci.org/articles/vie...

Sticky membranes of dead red blood cells obstruct small vessels Damage to the vascular lining leads to interactions with red blood cells that hint at how to treat dangerous complications of heart attack, stroke and COVID-19.

Damage to the vascular lining leads to interactions with red blood cells that hint at how to treat dangerous complications of heart attack, stroke and COVID-19

https://go.nature.com/4jyBzpe

Congratulations to all @labsakamoto.bsky.social group members for being the worthy winners of the K.I.S.S campaign! 🏆 👏 💪 Special mention to our lab manager, Marianne, for her persistence to make sure everyone gets their risk assessments done. Thanks @cbmr.science for this important initiative.

Unravelling cysteine-deficiency-associated rapid weight loss - Nature Conditional cysteine restriction in mice causes substantial weight loss, exceeding that seen with essential amino acid restriction, by activating the integrated stress and oxidative stress responses, and by unexpectedly depleting coenzyme A, leading to metabolic inefficiency.

Nature research paper: Unravelling cysteine-deficiency-associated rapid weight loss

https://go.nature.com/4mpetns

Skeletal muscle mitochondrial health in type 1 diabetes: the role of exercise capacity and lifestyle factors - Diabetologia Aims/hypothesis Previous studies reporting lower skeletal muscle mitochondrial function in type 1 diabetes did not account for cardiorespiratory fitness, a key confounder when assessing mitochondrial ...

Habitual exercise, optimal glucose management and a healthy BMI maintain mitochondrial health in individuals with type 1 #diabetes
@diabetologiajnl.bsky.social link.springer.com/article/10.1...

Cryptic infection of a giant virus in a unicellular green alga Latency is a common strategy in a wide range of viral lineages, but its prevalence in giant viruses remains unknown. In this work, we describe a 617–kilo–base pairs integrated giant viral element in t...

A giant virus in the genome of Chlamydomonas - this week in @science.org
#plantscience

Cryptic infection of a giant virus in a unicellular green alga | Science www.science.org/doi/10.1126/...

Revolutionary!!

Congratulations, Conchita on a very well deserved & well earned degree 🍾 We look forward to celebrating more of your achievements & are glad that you will stay with us a little longer. Congratulations to our group leader @keisakamoto.bsky.social for his mentorship & guidance over the years 🙏

Special day for our group @cbmr.science as we celebrate the successful defense of our (first) freshly minted PhD, Dr. Conchita Bringas 🥳 Her thesis was based on characterizing novel #AMPK inhibitors. Special thanks to the great committee @rbdamgaard.bsky.social ,Dave Carling & Lykke Sylow.

Congratulations, Conchita on a very well deserved and well earned PhD 👏 We are happy that you will continue to be with us for some more time. We look forward to celebrating more of your achievements! 🥳
Congratulations also to @keisakamoto.bsky.social for his mentorship & guidance 🍾

The do’s and don’ts of scientific image editing Acceptable image-editing practices are partly a matter of common sense. But researchers say journals and funders could help scientists by standardizing policies.

Acceptable image-editing practices are partly a matter of common sense. But researchers say journals and funders could help scientists by standardizing policies.

https://go.nature.com/437FWT6

GDF15 links adipose tissue lipolysis with anxiety - Nature Metabolism Anxiety-like behaviour in mice, as a result of psychological stress, is shown to be mediated by GDF15 release in response to adipose tissue lipolysis.

New from the Steinberg lab #GDF15 drives anxiety like behaviors in mice and is linked to adipose tissue lipolysis.

3D Mitochondrial Structure in Aging Human Skeletal Muscle: Insights Into MFN‐2‐Mediated Changes Changes in mitochondrial structure and dynamics during aging provide a mechanism for the development of age-related sarcopenia, a condition characterized by muscle mass loss. Through the creation of ....

3D Mitochondrial Structure in Aging Human Skeletal Muscle: Insights Into MFN-2-Mediated Changes
onlinelibrary.wiley.com/doi/10.1111/...

Mechanomedicine for Addressing Skeletal Muscle Insulin Resistance Abstract. Skeletal muscle insulin resistance (IR) is a critical deficiency in IR pathophysiology that significantly affects overall metabolic health. Skele

Mechanomedicine for Addressing Skeletal Muscle Insulin Resistance.

Baffling chronic pain eases after doses of gut microbes A small, preliminary trial and studies in mice draw links between fibromyalgia and alterations of the gut microbiome.

A trial has drawn links between fibromyalgia and alterations of the gut microbiome

https://go.nature.com/3EDZxkv