Alice Perucca

7/7 Friends 🎈 I am incredibly grateful to have worked alongside my wonderful co-first author, @oriolmb.bsky.social. This project has been a surprising journey, filled with challenges, triumphs, and lots of laughs. Cheers to the friendships made through science!

10.02.2025 16:42 — 👍 4    🔁 0    💬 1    📌 0

6/7: Thanks! This work wouldn't have been possible without the contributions of co-authors: @oriolmb.bsky.social Andrea Gomez and all the authors: Alex Calon, Anna Labernadie @challopeau.bsky.social et al. Special thanks to @xaviertrepat.bsky.social for the opportunity to take part in this project.

10.02.2025 16:42 — 👍 2    🔁 0    💬 1    📌 0

5/7: Impact. MIRO offers a valuable ex vivo platform that helps uncover mechanisms of immune exclusion potentially accelerating drug development, bridging the gap from lab to clinic 💊, ultimately improving patient outcomes. #TranslationalResearch

10.02.2025 16:42 — 👍 1    🔁 0    💬 1    📌 0

4/7: MIRO enables high throughput testing of #immunotherapies, opening new possibilities for personalized cancer treatments.
As a proof of concept, we restored anti-cancer immunity in resistant/immune-excluded HER2+ breast cancer with IL2 treatment. 💪
🎥 Immune cell migration upon treatment

10.02.2025 16:42 — 👍 3    🔁 0    💬 1    📌 0

3/7: Why MIRO is unique?
✅ Immunocompetent: tracks #ImmuneCells movement & interactions
✅ Cells self-organize & build their own extra-cellular matrix
✅ Cost-effective, reproducible & user-friendly
🎥 cellular organization in MIRO
#ECM #TumorEcosystem

10.02.2025 16:42 — 👍 2    🔁 1    💬 1    📌 0

Left: 3D schematic representation of the cellular organisation in MIRO. Right: comparison between MIRO and patient sample cellular organization.

2/7: MIRO is an open fluidic device that models the tumour-stroma interface using patient-derived cells. This allows us to recreate aspects of the #TumorMicroenvironment and study immune cell interactions in the lab. 🔎🧫 #Microfluidics #OnChip

10.02.2025 16:42 — 👍 4    🔁 0    💬 1    📌 0

Micro Immune Response On-chip (MIRO) models the tumour-stroma interface for immunotherapy testing - Nature Communications Modelling the tumour immune microenvironment in vitro is a valuable tool to test immunotherapy efficiency but capturing its complexity is challenging. Here authors present a fully humanised in vitro p...

1/7: New paper alert! Excited to share our co-first author paper on Micro Immune Response On-chip (MIRO) a model that recreates the tumour-stroma interface for immunotherapy testing! @oriolmb.bsky.social and I wrote this thread to break it down for you. 👇🧵
Read more: www.nature.com/articles/s41...

10.02.2025 16:42 — 👍 29    🔁 13    💬 1    📌 1

Researchers develop a device that replicates tumours to study the efficacy of immunotherapy treatments The Micro Immune Response On chip (MIRO) allows tumours and their environment to be replicated in order to understand their response to immunotherapy-based treatments.

Work conceived by Anna Labernadie during her postdoc in the lab—now running her group at CIPF—in collaboration with Alex Calon from @researchmar.bsky.social. Congrats to first authors @aliperri.bsky.social , Andrea Gómez and @oriolmb.bsky.social ! ibecbarcelona.eu/researchers-...

07.02.2025 11:45 — 👍 12    🔁 3    💬 1    📌 0

New paper from the lab🎈. Introducing Micro Immune Response On-chip (MIRO), a device that replicates tumors and their microenvironment to better understand responses to immunotherapies (cyan=immune cells, red=cancer, green=CAFs).
www.nature.com/articles/s41...
@ibecbarcelona.eu

07.02.2025 11:45 — 👍 143    🔁 42    💬 7    📌 4

Kicking off my Bluesky account with great news! Our work on MIRO, a device designed to study how cells respond to different immunotherapies, is now published. Have a look!

06.02.2025 16:38 — 👍 9    🔁 3    💬 0    📌 0