Marija Matejčić

A multicellular star-shaped actin network underpins epithelial organization and connectivity - Nature Communications The combined role of cellular junctions and actomyosin networks in tissues remains unclear. Here, the authors identify a tissue-scale star-shaped network of actomyosin that preserves cell shape, limit...

Check out @danielkrueger.bsky.social (@hansclevers.bsky.social lab) recent work on this process! www.science.org/doi/10.1126/...
With our two studies, I think we're steamrolling towards mechanistic understanding 💪of how and when our intestines lose their cells - sometimes few, other times too much..

Intestinal villus cells extrude living, following a calcium pulse. Unlike from extruding apoptotic cells, Ca2+ messaging stops at the first neighbors! #FluorescenceFriday

Part of our TrepatLab preprint: www.biorxiv.org/content/10.1...

Video by @ronjahoutekamer.bsky.social @gloerichlab.bsky.social

About our grants As a not-for-profit publisher, The Company of Biologists uses surplus income to benefit biology and the biological community. A key way in which we do this is through our grants, which support and encourage the sharing of knowledge throughout the community by facilitating international collaboration, event attendance and the organisation of scientific meetings, conferences and workshops. We offer the following grants: Scientific Meeting Grants Small Meeting Grants Grants from our Fund for Innovations in Sustainable Conferencing Travelling Fellowships DMM Conference Travel Grants JCS-FocalPlane Training Grants JEB Grants for junior faculty staff Development’s Pathway to Independence programme In addition, the British Society for Developmental Biology, British Society for Cell Biology and the Society for Experimental Biology offer travel grants as part of the funding we give them.

They are a REMARKABLE supporter of scientists and the community. In addition to their five journals, they support dozens of scientific meetings each year, and provide travel grants and other support 2/n
www.biologists.com/grants/

Thank you, Mark! The Adhesion GRC was such a rich, beautiful conference, thank you for making it happen. It was an absolute honor to be able to present there.
The preprint for that story is out now: bsky.app/profile/mari...
and we continue digging deeper into the mechanisms.

Villus cells seem to be mechanically predisposed to extrude..
We're working hard to nail down these mechanisms, from the initial impulse for extrusion to its execution through out-of-plane #torque generation. More to come!

@xaviertrepat.bsky.social lab
@ibecbarcelona.eu
@embo.org LTFellowship

On cell extrusion in the #intestine!
After 80 years of observations, we finally took a deeper look thanks to 2D #organoids. We report:

3D #forces, #extrusion still only in the villus even without curvature, #lamellipodia generate 3D force.. and more. Have a look!
www.biorxiv.org/content/10.1...

Emergence of cellular nematic order is a conserved feature of gastrulation in animal embryos Nature Communications - The morphogenetic events that occur during gastrulation involve dramatic cell- and tissue-level changes. Here they show that propagation of nematic order, leading to...

Scientific collaborations come in many flavors & are fun because they expose you to new areas of science. That was definitely the case for this paper, out today. We were definitely in the passenger seat but it was fun to go along for the ride 1/n
rdcu.be/euiZB.

How to turn a layer of fibroblasts into a tulip 🌷?

Check out our new pre-print on shape-programmable living surfaces.

Led by @pauguillamat.bsky.social‬

www.biorxiv.org/content/10.1...

Beautiful story from the Krndija lab, tackling the unexpected challenges of complex epithelia. They show side-effects (or are they?) of building an epithelium out of distinct cell types, with junctional fractures at the heterotypic interface.
Is there any reinforcement of 3CJunctions?

A checklist for designing and improving the visualization of scientific data - Nature Cell Biology Creating clear and engaging scientific figures is crucial to communicate complex data. In this Comment, I condense principles from design, visual perception and data visualization research in a checkl...

... and a few minutes ago our Chart-Checklist came out in @natcellbio.nature.com 🥳🎉

Gift link for #TCTeAC:
rdcu.be/eqPpi

www.nature.com/articles/s41...

Very useful thread from the best fan club @epimechfc.bsky.social on different (newish) image analysis software. Have a look, add the ones you use!
Is it time for a review article?

All @mpi-cbg.de alumni, of course. I had forgotten the tag, with all the disbelief about US research funding dismantling.

It was such a pleasure to meet everyone again, after we've all scattered around the world to continue our work. We will continue to support each other, come what may.

It's been 2 mere months since the magnificent #CellBio24 @ascbiology.bsky.social @embo.org in San Diego and my first ever trip to the US. It's hard to believe the amount of chaos that's happened since then..

Throwback with @paulinastrzyz.bsky.social Karina Pombo-Garcia, Chris Schmied, Jeff Woodruff

We have a new #stopdoing #science meme, courtesy of Miquel Bosch Padros from the @xaviertrepat.bsky.social lab. Late for #mechanobiology Monday, but here to stay on your lab meme boards forever.

From the StopDoingScience community on Reddit: STOP DOING BIOLOGY Explore this post and more from the StopDoingScience community

www.reddit.com/r/StopDoingS...

"Politics aside (ha! as if!)", I don't think these will ever get old for me, but they do shine extra bright these days.
"..." Stolen from @harmitmalik.bsky.social

#biology #stopdoing #science

ScaDS.AI Dresden/Leipzig ScaDS.AI Dresden/Leipzig is a german competence center for research on AI, Big Data and Data Science. Find out more!

Please welcome @scadsai.bsky.social on bluesky! We at ScaDS.ai are a federally funded artificial intelligence research center with headquarters in Dresden and Leipzig, Germany!

Beautiful findings, showing that at a critical tissue density, YAP is heterogeneously expressed in intestinal cells, leading to all sorts of responses that help regeneration. Well done Connie @cschwayer.bsky.social and all ✨

Thank you for coming to hear it, Paulina! 💕

See you in San Diego old and new friends! Join me and my talk in the organoid subgroup on Wednesday at 9:15 AM for a dive into the elements that drive intestinal cell extrusion. It's a very pretty, fundamental story ✨

I think this will be fun and very useful! Writing well is thinking well #devbiolwriteclub