Nimesh Chahare

Beautiful thread😍 about Flipper from @juanmagararc.bsky.social #EpithelialMechanics

Hello epithelial mechanics fans!! I’m Juanma @juanmagararc.bsky.social 👋 I work on cell mechanics (see celldynamicslab.com) and use Flipper-TR FLIM to probe membrane biophysics in cells.

Join me on this tour about Flipper: what it measures, strengths, advice, cool case studies, and cute drawings!

Epithelial Mechanics Fan Club @epimechfc.bsky.social is top-fin #scicomm, in case you haven't heard of it!

Follow them for more like this thread posted by Knaut Lab member and #zebrafish lateral line guru, @weiyiqian.bsky.social 🐟

PhD job alert! 🚨Interested in epithelial mechanics and bacterial infection? Do you have a computational background? Don’t miss this opportunity!

Details in thread 🧵👇

#AcademicJobs #PhDPosition #Biomechanics
Please RT 🔬💻 @epimechfc.bsky.social @unizar.es @i3a.unizar.es @esbiomech.bsky.social

How can structures at the vertex of 3 cells have effects at the tissue level?

Join me, @laura-rustarazo.bsky.social, to explore how tricellular junctions (TCJs) act as local tension sensors and regulators of global tissue organization. 🧵⤵️ doi.org/10.1126/scie...

Lobbying in Albany with @uaw.org and @cpw-uaw4100.bsky.social for the Empire Biomedical Research Institute. Learn more:
@fundnyscience.bsky.social.

How does a uniform zygote reliably break symmetry?
How do initially identical cells diverge in cell-cycle timing and transcriptional state?

In our new paper in Nature Physics, we show that embryo geometry itself is sufficient to pattern early development.

www.nature.com/articles/s41...

How can embryos use pulsatile contraction to shape tissue development during morphogenesis? I'm @weiyiqian.bsky.social and with this thread I want to introduce the roles of pulsatile actomyosin in animal development and the mechanisms that drive actomyosin to pulse

Very nice new preprint from the lab!
Congrats @yuieda1.bsky.social @jeromegros.bsky.social

Permeability-driven pressure and cell proliferation control lumen morphogenesis in pancreatic organoids - Nature Cell Biology Using pancreatic organoids, Lee et al. show that the balance between epithelial tissue permeability-driven lumenal pressure and cell proliferation affects ductal morphogenesis.

Congratulations to Byung Ho from the @anne-grapin.bsky.social lab @mpi-cbg.de and the rest of the team to this fantastic publication: www.nature.com/articles/s41...

How can cells use information from neighboring cells to improve the spatial precision of morphogen patterns? 🤔

We show that cells can gain positional information by "talking" to their neighbors - how much depends critically on spatial correlations of the patterns.

buff.ly/w56OUJT

Tissue mechanics and synth morphogenesis folks!
Would you or someone in your lab be up for recording a video of a protocol you use? Something hard to explain without seeing it done?

In the limbo hours 🌀 between today and 2026🌟, if something comes to mind -get in touch!
#JoVE organizes the filming 🤳

Beads moving around in the lumen of a developing lung, taken my first month of my postdoc when I was playing around with how I could make different viscoelastic material measurments.

Modelling co-development between the somites and neural tube in human trunk-like structures - Nature Cell Biology Makwana, Tilley et al. generate human stem cell-based trunk-like structures approximating Carnegie stage 13–14 of development. They use them to model and study the development of the thoracic and lumbar trunk.

Lovely little pre-Christmas present to see this out @natcellbio.nature.com! Some 🔥 new results in here since the biorvix incl (1) a new RARE-GFP reporter ✳️🙌, (2) additional NMP quantification 🔢, (3) no neural tube patterning on RA inhibition 🙅 etc. Enjoy! 😍 www.nature.com/articles/s41...

For this festive season, I’m sending friends and family something a little different: postcards straight from the microscope. 🔬

Featuring my hiPSC Christmas tree from last year and a hiPSC colony turned into a festive bauble, with wishes for a season that’s festive at every scale. 🎄

I am putting together a collection of video-protocols we (will) use in tissue mechanics research🌀
I hope to help consolidate established methods, but also showcase a few up-and-coming ones in our blooming field.
Abstract submission by March 2026! Get in touch✨
#JoVETissueMech
#ReproducibleTissueMech

Cells can sense the geometry of their environment, from tiny subcellular features to whole-tissue patterns. How can we engineer environments to systematically probe these responses?

🧵 I'm @lhinderling.bsky.social from @olivierpertz.bsky.social lab, let’s do a short tour on microfabrication!

Epithelial Mechanics Fan Club - FocalPlane Epithelial Mechanics Fan Club - News

Meet the Epithelial Mechanics Fan Club @epimechfc.bsky.social
Nimesh Chahare @onenimesa.bsky.social and Julia Eckert @juliaeckert.bsky.social introduce us to the Epithelial Mechanics Fan Club.
Learn how you can get involved with this community: focalplane.biologists.com/2025/12/04/e...

It’s time to talk about epithelial geometry and cancer. How can the architecture of an epithelium affect how tumors will grow and spread? In this thread, @jorgealmagro.bsky.social

Exciting News! 🥳 Our Epithelial Mechanics Fan Club website is now live! 🎉
👉 epithelialmechanics.github.io

Discover our #EpithelialMechanics threads and get to know our amazing delegates behind them.
Would you like to share your story? Please DM us!

Join the coolest club on the internet!
#EpithelialMechanics

Epithelial Mechanics Fan Club

🎉🎉 We finally have a website! 🎉🎉

Did you miss a thread?
Want to know who our delegates are?
Do you want to join our big club?
Check it out:
epithelialmechanics.github.io

Huge thanks to all thread-contributors and to you for following us!

📣Announcing the 4th edition of the EMBL‑IBEC Conference on “Engineering Multicellular Systems”, taking place 11–13 March 2026 in Barcelona. Exploring organoids, mechanobiology, embryo models, organ-on-chip systems, multiomics and more. Abstracts open now!
events.ibecbarcelona.eu/embl-ibec-co...

1/ 🐣⚒️ To study mechanics, we need to apply prescribed forces - how can we do that in living tissues? I am @eigenp.bsky.social and in this thread I'll highlight our new approach for applying tension on epithelial tissues in vivo!

Congratulations Isabela 🎉 🎉

Happy to share that my PhD has finally taken the shape of a paper! ✨

Huge thanks to all authors, especially @davidbrueckner.bsky.social & @ehannezo.bsky.social for leading the modeling and @raimonsunyer.bsky.social & @xaviertrepat.bsky.social for their invaluable supervision.

🧵👇

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇

Gut epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes Gut epithelium modulates output from distinct enteric circuits by altering secretion of insulin and noninsulin peptides.

Very excited to share this finding from my postdoctoral work that is now published in #ScienceAdvances. We show how the gut’s epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes.

www.science.org/doi/10.1126/...

Thread ⬇️

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Mechanosensitive and Reversible Chromatin-Lamina Dewetting Triggers Cellular Contraction During Wound Healing Tissue wounding causes rapid mechanical changes in the epithelium, but how these changes affect intracellular organization remains unclear. Using the Drosophila embryonic epidermis, we show that wound...

1/ Link: www.biorxiv.org/content/10.1...
✂️ Wounding in the fly epidermis makes chromatin compact + detach from the lamina.
⏱️ Minutes later it re-expands & re-attaches.
A reversible, nuclear “dewetting” cycle right at the wound edge.

👀🚨 Fantastic preprint from @andreuion.bsky.social

There's a lot going on inside the nucleus. #EpithelialMechanics