Nan Zhang

With boost to NIH budget, Senate panel rejects Trump’s plan to slash agency Republicans on spending committee push back against proposed reorganization and overhead cuts

The National Institutes of Health’s budget, and structure, would be preserved under a Senate bill for the 2026 fiscal year.

Here is the bill approved today by the subcommittee. Fingers crossed for next steps. www.appropriations.senate.gov/imo/media/do...

Senate committee endorses NIH budget increase, rebuking Trump administration’s proposed 40% cut Senators from both parties endorsed a $400 million increase to the budget of the National Institutes of Health on Thursday

This just in…

FY’26 Bill Highlights:

National Institutes of Health: $48.7 billion for biomedical investments in research.

Cancer: $7.4 billion for the National Cancer Institute, including $28 million for the Childhood Cancer STAR Act.

www.statnews.com/2025/07/31/n...

Cautious optimistic! Was there a streamed hearing? What’s the source?

Nowosad Lab will be recruiting postdocs soon. Reach out if you are interested!

Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression.

#MicrobiotaPower via #Exercise! Phelps, Meisel &co show @cp-cell.bsky.social that exercise drives formate from microbiota that in turns activates NRF2 in CD8 T cells driving STAT1/IRF8 programs that potentiate immune checkpoint inhibitor efficacy against #melanoma! dlvr.it/TLqLW7

Post-Doctoral Fellow - Zhang Lab - Philadelphia, Pennsylvania (US) job with The Wistar Institute | 12841397 The Wistar Institute has an opening for an ambitious and productive Post-Doctoral Fellow to join the laboratory of Dr. Nan Zhang.

We are hiring! Please help spread the words. Thank you!

Abstract deadline extended to Monday, June 30! And travel grants are still available to student and post-doc members. Don't miss out - REPOST to share the info with others.

Last week was big for IL-12 engineering @cytokinesociety.bsky.social : Membrane-IL12 adjuvant mRNA vaccine polarizes pre-effector T cells for optimized tumor control url:https://rupress.org/jem/article-abstract/222/9/e20241454/278038/Membrane-IL12-adjuvant-mRNA-vaccine-polarizes-pre

An Il12 mRNA-LNP adjuvant enhances mRNA vaccine–induced CD8 T cell responses IL-12 is dispensable for CD8 T cell responses to mRNA vaccination, but an Il12 mRNA-LNP enhances CD8 T cell memory and protection.

Happy to be part of @kingofpathogens.bsky.social study showing mRNAs encoding IL-12 enhance CD8 T cell responses to co-administered HA mRNA vaccines. Study led by Emily Aunins and Anthony Phan from the Hunter lab @upenn.edu

www.science.org/doi/10.1126/...

They might need education more than research. 🧐🤷🏻‍♂️

188 PhD/graduate fellowships from private foundations, federal agencies and international organizations.

Database can be downloaded here: research.jhu.edu/rdt/funding-...

An open letter to graduate students and other procrastinators: it's time to write - PubMed An open letter to graduate students and other procrastinators: it's time to write

A few quotes I love from this article about writing: "There’s no such thing as thinking", "Writing. Is. Thinking.", "Without writing there is no thinking and no real opportunity for exchange in the marketplace of ideas."

IL-1β+ macrophages and the control of pathogenic inflammation in cancer While highlighting the complexity and heterogeneity of tumor immune microenvironments, the application of single-cell analyses in human cancers has identified recurrent subsets of tumor-associated mac...

#MustRead. For #TumorImminologyLovers & more, check this fantastic review @ostunilab.bsky.social &co @cp-trendsimmuno.bsky.social all about #IL1 from #macrophages & pathogenic #inflammation in #cancer. #ScienceMatters dlvr.it/TJslPb

Matrix-producing neutrophils populate and shield the skin - Nature A population of neutrophils in the skin produces extracellular matrix, providing a defence strategy by reinforcing the barrier properties of the skin and helping to block the entry of pathogens.

#TickTock⏰! Udeehardt, LaiGuan NG, @drusqui.bsky.social &co show @nature.com that skin #neutrophils produce in a circadian manner extracellular matrix potentiating skin barrier & that after injury they create TGFb-dependent rings of matrix shielding pathogens & foreign molecules!

That’s a good one!

😱Never heard of anything like this.

Whenever I feel hopeless, I’d look back 100 years and then feel much more grateful and hopeful with what we have now. I hope it doesn’t get worse than that. 🤐🤐🤐

Early-age efferocytosis directs macrophage arachidonic acid metabolism for tissue regeneration Mechanisms that differentiate the capacity of newborn immune cells to orchestrate tissue regeneration are inadequately understood. Lantz et al. discover that in response to dying cells, neonatal macro...

Beautiful work by Ed Thorp’s team. We did a journal club on this paper and learned a lot about the crosstalk between resident macrophages and cardiomyocytes through thromoxane signaling and efferocytosis.

www.cell.com/immunity/abs...

Happy to share our new study on the functional reprogramming of neutrophils in the brain tumor microenvironment by hypoxia-driven lactylation
@theaacr.bsky.social
@wistar.org
@moffittnews.bsky.social

#StandUpForSciencePhilly

Congratulations, Jie, Xiaoqin, and the team! Beautiful work!

Do we meet at City Hall or do we march to City Hall? I guess probably meet at City Hall since people will be from many different institutions.

Just noticed that the study section meeting was rescheduled to 4/10/2025 🤞

Neutrophil extracellular traps promote pre-metastatic niche formation in the omentum by expanding innate-like B cells that express IL-10 Lee et al. show that neutrophil extracellular traps (NETs) establish the pre-metastatic niche in the omentum by recruiting innate-like B cells and eliciting IL-10 production in these cells through ina...

Neutrophil extracellular traps promote pre-metastatic niche formation in the omentum by expanding innate-like B cells that express IL-10: Cancer Cell www.cell.com/cancer-cell/...

Thanks for sharing, Caroline!

This is the first movement from Sen. Fetterman, please fill out immediately if you have been impacted. Please circulate Penn, Pitt, PSU, Temple etc @cbartman.bsky.social

U.S. early-career researchers struggling amid chaos Uncertain funding, government firings, and distressed universities hit vulnerable groups especially hard

U.S. early-career researchers struggling amid chaos www.science.org/content/arti... #research #science

U.S. early-career researchers struggling amid chaos Uncertain funding, government firings, and distressed universities hit vulnerable groups especially hard

www.science.org/content/arti...