Carla Nowosad PhD

Leaving Basel after an amazing @embo.org meeting on Barrier Immunity! Bravo @maurogaya.bsky.social and @immunologyking.bsky.social for putting together such a brilliant lineup.

Great analogy to illustrate the question @carlanowosad.bsky.social is pursuing on her lab: how GC are form and how GC cells find their way to their specific locations

#embo workshop Basel

#immunalogy

Fantastic @embo.org young investigator lecture on lung B cell responses from @maurogaya.bsky.social #EMBObarrierTissues

Superstar 🤩

Vote for the extremely talented Helena here!!

The term 'affinity maturation' understates the influence of somatic hypermutation Three recent papers quantify how nucleotide-level mutation processes drive antibody evolution.

Why does selection feel so weak relative to mutation in affinity maturation? A new blog post giving three perspectives, including our new transformer-based model of natural selection on antibodies: matsen.group/general/202...

Love this series! Great to see some familiar faces in here 😎

Full Committee Markup of Defense and Labor, Health and Human Services, and Education Appropriations Acts | United States Senate Committee on Appropriations United States Senate Committee on Appropriations

🧪 Senate appropriators say: NIH's budget gets a... boost!

Rather than 40% cut, NIH gets a $400M *increase* in the Senate committee bill for FY26 (about +1%).

"Congress has your back," said @murray.senate.gov.

ADVOCACY MATTERS! There's still a long road (esp in the House), so keep up pressure.

Senator Murray Slams Trump Admin for Choking Off Lifesaving NIH Medical Research - Senator Patty Murray Washington, D.C. – Today, U.S. Senator Patty Murray (D-WA), Vice Chair of the Senate Appropriations Committee, issued the following statement on reports today that President Trump’s Office of Manageme...

BREAKING: Trump wants to illegally cut off $15 billion in lifesaving NIH research.

Research to cure cancer, Alzheimer's, and so much more is on the line.

These people are LYING about waste, fraud, and abuse at NIH to justify attacking medical research—we all need to say so.

My full statement. ⬇️

And share widely please, both here and when you are chatting to great graduating students!

Starting up OnlyLabs, where people can pay to watch researchers who used to have federal funding do Hot Uncensored Cutting Edge science experiments.

Nowosad Lab will be recruiting postdocs soon. Reach out if you are interested!

S1P is produced in the outer lymph follicle area and degraded by B cells resulting in a negative gradient towards to follicle center. S1PR2 signalling on GC B cells leads to migration arrest, keeping B cells within the follicle. (🐭 data)

Green et al 2011 🧪⑂
www.nature.com/articles/ni....

Research funding cuts: What's at stake Researchers like Richard Huganir are closing in on a cure for SYNGAP1-related disorders. But in the face of federal funding cuts, can they finish what they started?

'Under the new administration, the NIH, which for more than 75 years has supported scientists who are pursuing research deemed to be in our national interest, is pulling back. Budgets are being slashed.'

Big day for the lab today 🧪

Congrats to Gaby Berman, officially a Nowosad Lab PhD candidate!!

Please share this widely and encourage students to apply! Many of our current graduate students were recruited through this program -- happy to answer any questions and connect with students
bsky.app/profile/stan...

Cream puffs in a tip box can only mean one thing… a celebration!

Nowosad Lab milestone- first student qualifying exam complete 🥲

We set out to quantify U.S. academic contributions to medicines. The results stunned even us From 2020 to 2024, universities contributed patents underpinning 50% of FDA-approved drugs. 87% of those academic breakthroughs came from American institutions.

The astounding contribution of US academic science to new medicines

www.statnews.com/2025/06/06/u...

“Out Of His Depth,” “Sold His Soul,” “Clueless”: NIH Staffers Speak Out About Director Bhattacharya Widespread dissatisfaction over the NIH’s “continuous free fall” has people speaking out.

NEW: Important Context spoke with a dozen people working at NIH about Director Jay Bhattacharya.

The descriptions were universally unflattering, painting the health economist as ineffectual, dishonest, ideological, arrogant, and uncommitted to science.

www.importantcontext.news/p/out-of-his...

screenshot from the NSF budget request to congress showing that the number of people involved in NSF activities will drop from 330,100 to 90,000.

The bottom line with the proposed cuts to NSF is to cut the number of working scientists and disappear opportunities to train new scientists.

This is a PROPOSED budget to Congress. Call your reps.

Presidential budget proposes a 70% reduction in NSF funding for 2026 compared to2024.
Instead of funding 23% of proposals (2024) they will fund 7% (2026).
A perfect recipe for the destruction of American science.

RORγt+ antigen-presenting cells mediate food tolerance - Nature Reviews Immunology Five recent papers identify the RORγt+ antigen-presenting cells that induce food-antigen-specific regulatory T cells and establish food tolerance.

Not one, not two .... but FIVE recent papers highlighting a role for RORgt+ antigen-presenting cells in the gut in establishing tolerance to food antigens
#oraltolerance #immunosky #foodallergy

Adaptive immunity in barrier tissues Immune responses lie at the heart of almost every aspect of human health, including host responses to infection, autoimmunity, cancer, metabolism and aging. While adaptive immune responses by B and T…

Last chance TODAY - to register and submit abstracts for #EMBObarrierTissues in Basel 🇨🇭🇨🇭🇨🇭! We've hit our registration goal 🥳, but there's always room for more. Join @maurogaya.bsky.social and me to explore the latest in lymphocyte and mucosal immunology. Details: meetings.embo.org/event/25-bar...

The last few days were a much needed reminder that community is everything in science. Thanks V Foundation, you guys are the coolest.

Maternal gut microbiota influences immune activation at the maternal-fetal interface affecting pregnancy outcome @natcomms.nature.com
www.nature.com/articles/s41...

Non-cognate B cells can enter germinal centers, undergo SHM, and acquire new antigen specificities, highlighting the capacity of antibodies to generate new recognition through SHM @cp-immunity.bsky.social
www.cell.com/immunity/ful...

Beyond the lab: trust, storytelling and the fight for America’s attention - Nature Reviews Immunology Shruti Naik, an immunologist and a strong advocate for diversity in science, has joined forces with Aaron Mertz, who leads programmes that help to explain, connect and maximize the benefits of science...

Misinformation is winning not because it's true, but because it’s loud, emotional, and everywhere.
It’s time for science to fight back. Aaron Mertz and I dissect the issue and offer solutions 👇
📖 www.nature.com/articles/s41...
#SciComm @sinaiimmuno.bsky.social @aspeninstitute.bsky.social

Somatic hypermutation unlocks antibody specificities beyond the primary repertoire Initial specificity is thought to be required for somatic hypermutation (SHM)-driven antibody evolution. Zuo, Gautam, et al. demonstrate that non-cognate B cells can enter germinal centers, undergo SHM, and acquire new antigen specificities, highlighting the capacity of antibodies to generate new recognition through SHM.

Online now: Somatic hypermutation unlocks antibody specificities beyond the primary repertoire

This meeting is going to be so fun!