iMeta Science

Nationwide profiling of vaginal microbiota in Chinese women reveals age‐dependent shifts and predictive biomarkers for reproductive health The vaginal microbiome is central to reproductive health, yet large-scale studies in East Asian populations remain scarce. Here, we characterized the vaginal microbiota of 6423 Chinese women of repro...

🌸 Profiling 6423 Chinese women, this study uncovers a midlife shift in the #vaginal #microbiota—
⚖️ Decline of #Lactobacillus crispatus, rise of #Gardnerella vaginalis around age 40.
🧠 A new #microbiome balance score predicts reproductive health risks.
🔗 doi.org/10.1002/imt2...

🧬 CycloneSEQ #nanopore sequencing rapidly reconstructs multidrug-resistant bacterial genomes!
⚙️ 96.16% read accuracy, 99.98% assembly accuracy.
💡 Complete genomes with just 15× long reads or 5× hybrid data.
🔗 onlinelibrary.wiley.com/doi/10.1002/...
#Bioinformatics #BGI

Host–microbiota interaction drives 5‐hydroxyindole‐3‐acetic acid production to promote linear growth in infant mice This study discovered that Lactiplantibacillus plantarum Hi188 promoted linear growth in postweaning mice. Transcriptomic analysis, untargeted metabolomics, and in vitro experiments showed that the e...

🐭 #Lactiplantibacillus plantarum Hi188 promotes post-weaning growth in mice.
🧪 The #metabolite 5-HIAA activates hepatic #AhR, boosting IGF-1 production.
🧑‍💻 Metagenomic and host transcriptome data reveal that 5-HIAA is co-produced by the host–microbiota axis.
🔗 doi.org/10.1002/imo2...
#microbiome

Convergent evolution of metabolic functions: Evidence from the gut microbiomes of humans and dogs Dogs have undergone convergent evolution in their genome with humans in long-term co-living. Studies have shown that the gut microbiomes of dogs exhibit greater similarity to those of humans compared...

🐶💩 Humans and dogs share more than companionship — their gut microbes evolve together!
🧬 Dogs’ gut microbiomes show greater functional similarity to humans than macaques do.
🔗 onlinelibrary.wiley.com/doi/10.1002/...
#microbiome #metabolism

iMeta Conference 2025: Creating high‐impact international journals The iMeta Conference 2025, part of the iMeta Conference series, themed “Creating High-Impact International Journals,” held at the Huangjiahu Campus of Hubei University of Chinese Medicine from August...

🌟 #iMeta Conference 2025
🧬 Focus: #Microbiology, #medicine, #TCM, #plant science & research talent development
🤝 Empowering innovation & advancing journals globally
🔗 onlinelibrary.wiley.com/doi/10.1002/...
#Bioinformatics #microbiome #metagenomics

Artificial Intelligence Revolutionizes Anti‐Infective Drug Discovery: From Target Identification to Lead Optimization Artificial intelligence (AI) technology is revolutionizing antimicrobial drug development. In response to increasingly severe antimicrobial resistance challenges, AI can efficiently predict pathogen ...

💥 Can AI solve the #antibiotic resistance crisis?
🤖 By revolutionizing every step of drug discovery—from target ID to lead optimization.
🧬 Two paths: molecular screening & de novo design.
⚙️ #AI accelerates discovery, boosts ADMET prediction & drives multi-target innovation.
🔗 doi.org/10.1002/imm3...

💡 30 scientific recommendations from the #CHINAGUT Conference!
👩‍🔬 63 experts joined forces to shape the future of:
🦠 #Probiotics
💊 Live biotherapeutic products
💩 #FMT
The goal: standardization, regulation & precision in #microbiome-based therapies.
🔗 doi.org/10.1002/imt2...

Multiomics analyses reveal that PRMT5 regulates membrane transport and cholesterol synthesis in white adipocytes Prmt5AKO downregulates genes related to fatty acid transport and triacylglycerol synthesis, while upregulating genes involved in glucose transport and cholesterol biogenesis. These changes cause alte...

🍩 What happens when Prmt5 is lost in fat cells?
🧬 Lipid genes go down, #glucose metabolism goes up!
💥 #Triglycerides drop while phospholipid & sphingolipid diversity expands.
PRMT5 emerges as a key regulator of membrane transport & #cholesterol synthesis.
🔗 doi.org/10.1002/imo2...

Yongxin introduces numerous methods published in iMeta @imetascience.bsky.social
#BGIspatialmicrobiome

The combined influence of microbiome and soil environment contributes to the chemotype differentiation in Atractylodes lancea Genetic differentiation between the Maoshan-Dabie Mountains group (MA genotype) and Qinling-Taihang Mountains group (SA genotype) of Atractylodes lancea occurs along altitude and climatic gradients. ....

🌱 What shapes the chemotypes of Atractylodes lancea?
Not genes alone!
🧬 Genetic divergence follows altitude & climate.
🌾 #Soil and #microbiome together tune its metabolite profiles.
🦠 Core #rhizosphere & endophytic microbes hold the key.
🔗 doi.org/10.1002/imo2...

Stigmasterol attenuates atherosclerosis by inhibiting inflammatory signaling and foam cell formation Stigmasterol mitigates atherosclerotic plaque formation by modulating foam cell phenotypic alterations and cholesterol metabolism. Stigmasterol inhibits inflammatory CD86+ macrophage polarization via...

🫀 Can plant sterols fight #atherosclerosis?
✅ Yes! #Stigmasterol reduces inflammatory macrophages & foam cells.
💡 It boosts cholesterol efflux, blocks ox-LDL uptake, and modulates AMPK/NF-κB/NLRP3 signaling.
📉 The result: less vascular #inflammation, healthier arteries.
🔗 doi.org/10.1002/imo2...

Metagenomic mining reveals novel Cas12 subtypes and their evolutionary diversification We identified 4112 Cas12 Proteins and 6 new Cas12 subtypes, revealed their significant diversity in N-terminal regions, repeat sequences, and sequences motifs. We developed an AI-driven algorithm, Ca...

🧬 New insights into the diversity of #CRISPR–Cas systems!
#Metagenomic analyses uncovered 4,112 Cas12 proteins and 6 novel subtypes.
🤖 #AI-based Cas12fam annotates 18 domains.
🌿 Cas12 subtypes show habitat-specific enrichment.
🔗 doi.org/10.1002/imo2...
#microbiome #metagenomics #bioinformatics

iMeta: Boosting academic sharing and collaboration via social media Social media platforms have revolutionized scientific communication by bridging gaps between researchers, academic journals, and global audiences. This article showcases iMeta, an open-access journal...

🚀 #iMeta is reshaping academic communication!
📲 Multi-platform + bilingual strategy expands global reach.
📈 1.36M full-text downloads, >10K citations, IF 33.2 (2024)!
🌐 New sub-journals & events foster a vibrant research ecosystem.
🔗 doi.org/10.1002/imt2...
#Journal

Tumor Electrophysiology in Precision Tumor Therapy This review highlights tumor electrophysiological hallmarks as therapeutic targets in precision oncology. We examine how membrane potential alterations and ion channel fingerprints drive malignancy, ...

Abnormal membrane potentials & ion channel signatures drive #tumor growth, metastasis & immune evasion
💊 Ion channel drugs, tumor-treating fields & nano-delivery offer new precision therapies
🧠 Electro-immunotherapy reshapes the TME
🔗 doi.org/10.1002/imm3...
#CancerResearch #Immunotherapy

A comprehensive benchmarking for spatially resolved transcriptomics clustering methods across variable technologies, organs, and replicates Spatial clustering is a critical step in spatially resolved transcriptomics. Here, we conducted a comprehensive benchmarking analysis of 14 spatial clustering methods using ~600 datasets, including b...

🧬 Benchmarking 14 spatial clustering methods across ~600 #SpatialTranscriptomics datasets
🧫 10 technologies, 8 organs — consistent insights
⚙️ Clear guidance for method choice & preprocessing
🔗 doi.org/10.1002/imt2...
#Bioinformatics #SpatialOmics #scRNA

Soil pH modulates microbial nitrogen allocation in soil via compositional and metabolic shifts across forests in Japan This study reveals how soil pH regulates microbial N allocation in forest soils across Japan. We show that microbial abundance controls the overall rate of N cycling, while microbial composition and ...

🌏 #Soil pH shapes microbial #nitrogen cycling in Japanese forests 🌲
🧪 Acidic soils host stress-tolerant microbes retaining N
⚙️ Neutral soils favor energy-efficient taxa releasing #ammonium & driving #nitrification
🔗 doi.org/10.1002/imo2...

#SoilHealth #Microbiome #metabolism

A reciprocal interaction between L‐lysine and Holdemanella biformis modulates intestinal barrier function and anxiety in irritable bowel syndrome This study uncovers a complex interaction between l-lysine and Holdemanella biformis (H. biformis) in irritable bowel syndrome (IBS). l-lysine enhances intestinal barrier function and alleviates anxi....

🧩 New insights into the #gut–#brain axis:
🦠L-lysine boosts barrier function & eases anxiety via tryptophan metabolism
😟H. biformis strengthens the barrier but worsens #anxiety
💻Multi-omics reveal lysine degradation as a key mechanism
🔗 doi.org/10.1002/imo2...
#microbiome #Bioinformatics

FigureYa: A Standardized Visualization Framework for Enhancing Biomedical Data Interpretation and Research Efficiency FigureYa integrates 317 visualization tools across diverse biomedical domains, categorized by research type, analytical method, and output format. This resource streamlines data interpretation and en...

🚀 317 R scripts for biomedical research, no coding barrier
⏱️ Standardized design saves time
✅ Verified, annotated, reproducible
🧬 Covers #scRNA-seq, spatial #transcriptomics, #ML & more
🔗 doi.org/10.1002/imm3...
#Bioinformatics

🫀🦠 Gut–heart axis in #CAD: distinct microbial & metabolic shifts across normal, sCAD & ACS;
ACS signatures partly reversible.
Multi-omics #ML outperforms clinical risk factors in stratifying CAD subtypes.
🔗 onlinelibrary.wiley.com/doi/10.1002/... #microbiome

Lactobacillus johnsonii‐FM1 modulates gut microbiota and secretes anticancer metabolite vanillic acid to inhibit colorectal tumorigenesis Lactobacillus johnsonii-FM1 alleviates colorectal tumorigenesis in both ApcMin/+ and azoxymethane/dextran sulfate sodium mouse models by enriching beneficial gut microbiota, restoring epithelial barr...

🦠 #Lactobacillus johnsonii-FM1 fights colorectal #cancer:
🌱 Restoring gut diversity & barrier integrity
🔬 Producing VCA via vanillin dehydrogenase
❌ VCA blocks #CRC cell growth & Wnt/β-catenin signaling
👉 A gut microbe–metabolite axis for anti-CRC therapy.
🔗 onlinelibrary.wiley.com/doi/10.1002/...

fastp 1.0: An ultra‐fast all‐round tool for FASTQ data quality control and preprocessing The figure shows side-by-side quality comparison of the data before and after preprocessing using fastp 1.0. As can be seen from this figure, the data quality has been significantly improved after fa...

🚀 #fastp: ultra-fast, full-featured & user-friendly #FASTQ preprocessing tool!
☁️ Cloud-friendly, minimal resources, web-based reports
📊 v1.0 brings enhanced HTML reporting & parallel batch processing
onlinelibrary.wiley.com/doi/10.1002/...
#Bioinformatics #NGS #sequencing

Geographic containment and virulence‐resistance trade‐offs drive the evolution of hypervirulent Klebsiella pneumoniae The global emergence of hypervirulent, carbapenem-resistant Klebsiella pneumoniae (hvCRKP) poses a paradox: why do such dangerous clones remain geographically confined? By analyzing over 2500 CC23 ge...

🌍 New study on hypervirulent #Klebsiella pneumoniae (CC23-K1):
🔹 Geographic distance drives global spread patterns
🔹 >130 gain/loss events show unstable carbapenem resistance
🔹 KPC/NDM (Asia) conflict with #virulence, OXA-48 (Europe) better preserves it
🔗 onlinelibrary.wiley.com/doi/10.1002/...

🚀SCTP, a deep fusion model of #scRNA-seq, spatial & phenotypic #transcriptomics, quantifies #CRC malignancy with high accuracy.
✅ Detects subregions & warning genes missed by pathology
✅ SCTP-CRC generalizes to liver mets, validates #MUC2 biomarker
🔗 onlinelibrary.wiley.com/doi/10.1002/...
#cancer

GISDD: A comprehensive global integrated sequence and genotyping database platform for dengue virus, facilitating a stratified coordinated surveillance strategy GISDD, the Global Integrated Sequence and Genotyping Database for Dengue Virus (DENV), provides an integrated online analysis platform encompassing tools such as GISDDrlearn, GISDDprimer, and GISDDre...

🌐 Meet GISDD — an #AI-powered #Bioinformatics platform for fast dengue virus (DENV) genotyping & tracing.
Upload your sequence ➡️ get instant genotype, origin & risk insights.
Supporting global DENV surveillance & collaboration.
#DENV #Genomics #PublicHealth onlinelibrary.wiley.com/doi/10.1002/...

PSOSP uncovers pervasive SOS‐independent prophages with distinct genomic and host traits in bacterial genomes Prophages are ubiquitously present in bacterial genomes, significantly influencing host physiological and ecological functions. We present Prophage SOS-dependency Predictor (PSOSP), a novel bioinform...

🚀 PSOSP predicts #prophage induction!
From 49,333 genomes, we uncovered 11,806 SiPs, showing unique genomic/host traits and hinting at SiP–SdP interconversion.
onlinelibrary.wiley.com/doi/10.1002/...
Available: vee-lab.sjtu.edu.cn/PSOSP/
#Bioinformatics #microbiome

Unveiling soil microbial diversity through ultra‐deep short‐read metagenomic sequencing and co‐assembly By combining ultra-deep short-read shotgun metagenomic sequencing with 5-sample co-assembly across 600 agricultural soil samples, we significantly enhanced the representation and recovery of microbia....

Soil is the most diverse microbial ecosystem, which makes microbiome studies with shotgun sequencing extremely tricky!
In our last paper @imetascience.bsky.social, we show that co-assembly increases gene and genome recovery
tinyurl.com/59t4z8fh
#soilmicrobiome #metagenomics

#Tumor Electrophysiology in Precision Tumor Therapy #iMetaMed onlinelibrary.wiley.com/doi/10.1002/... #CancerTherapy #CancerResearch

Unveiling Origin Pitfalls in Metagenomic Surveillance for Emerging Infectious Diseases: Parvoviruses as a Model A diverse reagent-associated virome, including parvoviruses, misleads zoonotic surveillance. By leveraging large language models (ChatGPT-4o), we construct a virus discovery data framework (PVDDC) an...

Unveiling Origin Pitfalls in #Metagenomic Surveillance for Emerging Infectious Diseases: #Parvoviruses as a Model #iMetaMed onlinelibrary.wiley.com/doi/10.1002/... #mNGS #NGS #chatGPT #AI

iMetaMed Click on the title to browse this journal

🎉 Milestone for #iMetaMed!
We’ve just published our first paper, FastUKB 🚀
iMetaMed advances research in multi-#omics, big data, #AI & precision medicine in #healthcare.
More here: onlinelibrary.wiley.com/journal/3066...

Discovery of a novel tetrapeptide as glucose homeostasis modulator with bifunctionalities of targeting DPP‐IV and microbiota AI-driven and computation-based high-throughput methods were developed to mine novel dipeptidyl peptidase IV (DPP-IV) inhibitory peptides from hemp seed proteins. The identified peptide VAMP demonstr...

Discovery of a novel tetrapeptide as #glucose homeostasis modulator with bifunctionalities of targeting DPP‐IV and #microbiota onlinelibrary.wiley.com/doi/10.1002/...
#Akkermansia #AI #microbiome