Steve Fletcher

Without naming your job, tell me something you say over and over again at work.

What does the TLC look like?

That’s a good question-i‘ll get back to uou

My undergr supervisor was writing an organic chemistry text in Esperanto before he died

A colleague asked me if anyone can identify this glassblowing tool. From the collection of a distinguished long gone colleague.

Happy to hear thoughts.

no, I went to a liberal arts college

organic chemistry IV
art history
the new German film
society and freedom
contemporary myths

It’s Ollie!

Andrew gets it!

YouTube video by Dr. Seuss 🎤🎶 Wes Tank Raps One Fish, Two Fish, Red Fish, Blue Fish 🎶🎤 | @DrSeuss | Songs | Cartoons For Kids

youtu.be/VSJWvzLuGz8?...

Graphical abstract on small molecule discovery targeting TRMT112:METTL5

Activity-based protein profiling covalent small molecules that potentiate the activity of the METTL5:TRMT112 complex through binding to a complexoform-restricted allosteric pocket absent in other TRMT112:methyltransferase complexes

www.nature.com/articles/s41...

how many papers did you 'read' today?

We're Hiring! If you are interested in a PDRA post with the Mehta group, please apply! @ox.ac.uk @oxfordchemistry.bsky.social

my.corehr.com/pls/uoxrecru...

Access to four-membered cyclic sulfinamides by energy transfer catalysis Synthetic transformations that advance through excited states proceed by unconventional mechanistic pathways and deliver products not accessible using ground-state chemistry. The breadth of these synt...

In @science.org for chemsky this week, Michael Willis’ group make beta-lactam analogues with S=O in place of C=O, using energy-transfer reactivity of N-silyl sulfinylamine precursors.

www.science.org/doi/10.1126/...

Two (2) corkscrews went down trying to open this

Ok here it is - out of 44 FDA approvals this year, 31 are small molecules (70%), 26 of those are oral drugs (84%), 22 of them are chiral (71%). This is the largest number and percentage of chiral FDA approved molecules in a single year. Fitusiran is not a small molecule, bonus.

Lecturer / Assistant Professor of Organic Chemistry, UCD School of Chemistry, Permanent Applications are invited for a permanent post of a Lecturer / Assistant Professor of Organic Chemistry within UCD School of Chemistry. The successful candidate will have research interests in any area of Organic Chemistry, and these include, but are not limited to, the development of novel methods in synthetic chemistry, sustainability, supramolecular chemistry, natural products chemistry, green chemistry, catalysis, and industrial chemistry. The candidate will contribute to our undergraduate and postgraduate taught programmes in particular, curriculum development of our BSc programmes in (a) Chemistry, (b) Medicinal Chemistry & Chemical Biology and (c) Chemistry with Environmental and Sustainable Chemistry. The candidate will supervise and perform cutting edge research and contribute to administration of the school. 95 Lecturer / Assistant Professor (above the bar) 2010 Salary Scale: €64,753 - €102,539 per annum. Appointment will be made on scale and in accordance with the Department of Finance guidelines Closing date: 12:00 noon (local Irish time) on 27/02/2026. Applications must be submitted by the closing date and time specified. Any applications which are still in progress at the closing time of 12:00 noon (Local Irish Time) on the specified closing date will be cancelled automatically by the system. UCD are unable to accept late applications. UCD do not require assistance from Recruitment Agencies. Any CV's submitted by Recruitment Agencies will be returned. Note: Hours of work for academic staff are those as prescribed under Public Service Agreements. For further information please follow link below: https://www.ucd.ie/hr/t4media/Academic%20Contract.pdf

Come be my colleague @ucdchemistry.bsky.social!

We're currently looking for an organic chemist (broadly defined) to start as a permanent (i.e., tenured) assistant professor.

Job reference (www.ucd.ie/workatucd/jo...) is 019237. Due date Feb. 27, 2026

Reach out if you have questions!

Beep was nasty…

Black-and-white historical photograph showing a massive, billowing mushroom cloud rising high above a calm body of water. The cloud is dark and turbulent at the base, gradually lightening toward the top, with a thick stem connecting it to the surface. A small ship is visible in the foreground on the water, dwarfed by the enormous cloud, providing scale. The horizon is flat with distant land or trees faintly visible.

On Dec. 6, 1917 at 8:45 a.m., the Imo and Mont-Blanc (which was packed with explosives) collided in Halifax Harbour.
At 9:05 a.m., the Mont-Blanc exploded. The 2.9 kiloton blast levelled most of Halifax, killed 1,700 and injured 9,000.
This is the story.

📸 LAC

🧵 1/12

watching The wire - Omar easily one of the best bad guys ever

a hockey player wearing a blue jersey with the letter a on the front ALT: a hockey player wearing a blue jersey with the letter a on the front

A movie that takes place where I’m from

The chemotypes within FDA approvals so far this year are quite diverse. Most of the 2025 small molecule approvals are chiral with four covalent electrophiles.

smells like money and segphos

that's brilliant - thanks!

there must be like a go to replacement for industry when doing old reactions that called for that - I want to remove an PhSO2 group

no

I'd rather not use Hg

any suggestions for a equivalent reagent for Na/Hg?

#ICIQJobs

🚀 Join ICIQ as a Junior Group Leader!

We’re seeking talented, innovative scientists ready to push the frontiers of research.

Apply now 👉🏼 careers.iciq.org/jobs/6745027...

@cerca.cat @bist.eu #SOMM_alliance

It’s England so I appreciate how not everyone ‘gets it’ - but somehow my kid ended up with a moul piece of garlic and another got a brussel sprout from the same house. I suggested that they might not understand the full implications of ‘trick or treat‘ …