The Copp Lab @ UC Irvine

MPA-CINT Post Bachelors Student at Los Alamos National Laboratory Los Alamos National Laboratory is Hiring! Search available jobs or submit your resume now by visiting this link. Please share with anyone you feel would be a great fit.

Sharing this exciting post-bachelor's opportunity to work with Copp lab alum Dr. Anna Gonzàlez Rosell and her team! Please share with graduating seniors and others who may be interested!

lanl.jobs/search/jobde...

And one more talk @ 8 AM on photoluminescence in DNA-stabilized silver clusters:

And our collaborative work with the Bogdanov group on VAEs for designing nanomaterials:

Monday presentations from Copp Lab members at #ACSSpring2025 - catch Dr. Kylie Lytle's talk on her PhD work in the Sheldon lab, tomorrow @ 10:35 PST!

The first of many presentations from Copp Lab members at #ACSSpring2025 - catch Jayme Chow's talk tomorrow @ 11:40 PST!

Kingston friends please share widely. These are some of the top scientists in Japan and in the world.

Shining Bright at 960 nm: A 28‐Silver‐Atom Nanorod Stabilized by DNA Single-crystal X-ray data reveal the structure of a 28-silver-atom cluster wrapped within two DNA oligomers. In the crystalline state, two chlorido ligands are detected, which are absent in the mass ....

New DNA stabilized AgNC structure! 28 silver atoms with emission at 960 nm!
#DNA #silver #fluorescence #NIR
onlinelibrary.wiley.com/doi/10.1002/...

Congratulations to Gang Zheng! We are so excited about your collaborative work on nanoclusters for biomedicine - this could be a game changer for cancer therapeutics.

Dynamic Electronic Structure Fluctuations in the De Novo Peptide ACC-Dimer Revealed by First-Principles Theory and Machine Learning Recent studies have reported long-range charge transport in peptide- and protein-based fibers and wires, rendering this class of materials as promising charge-conducting interfaces between biological systems and electronic devices. In the complex molecular environment of biomolecular building blocks, however, it is unclear which chemical and structural dynamic features support electronic conductivity. Here, we investigate the role of finite temperature fluctuations on the electronic structure and its implications for conductivity in a peptide-based fiber material composed of an antiparallel coiled coil hexamer, ACC-Hex, building block. All-atom classical molecular dynamics (MD) and first-principles density functional theory (DFT) are combined with interpretable machine learning (ML) to understand the relationship between physical and electronic structure of the peptide dimer subunit of ACC-Hex. For 1101 unique MD “snapshots” of the ACC peptide dimer, hybrid DFT calculations predict a significant variation of near-gap orbital energies among snapshots, with an increase in the predicted number of nearly degenerate states near the highest occupied molecular orbital (HOMO), which suggests improved conductivity. Interpretable ML is then used to investigate which nuclear conformations increase the number of nearly degenerate states. We find that molecular conformation descriptors of interphenylalanine distance and orientation are, as expected, highly correlated with increased state density near the HOMO. Unexpectedly, we also find that descriptors of tightly coiled peptide backbones, as well as those describing the change in the electrostatic environment around the peptide dimer, are important for predicting the number of hole-accessible states near the HOMO. Our study illustrates the utility of interpretable ML as a tool for understanding complex trends in large-scale ab initio simulations.

Check out our collaborative work with the Sharifzadeh group @bostonu.bsky.social on interpretable ML to understand electronic structure of biomolecular materials @ps.uci.edu pubs.acs.org/doi/10.1021/...

I think, unfortunately, yes.

A Dual‐Emissive DNA‐Templated Silver Nanocluster with Near‐Infrared I and II Emission This study presents a dual-emissive DNA-stabilized silver nanocluster with a nanosecond-lived NIR-I emission band and a microsecond-lived NIR-II emission band. Mass spectrometry establishes that the ...

Together with
@voschlab.bsky.social, we present DNA-stabilized nanoclusters emissive in the NIR-II tissue transparency window.
onlinelibrary.wiley.com/doi/10.1002/...
@ps.uci.edu
Thanks to @chanzuckerberg.bsky.social for funding our work!

Applications are now open for the NSF-supported Future Faculty Workshop in Soft Matter, to be hosted at UC Irvine @ucirvine.bsky.social on July 15-17! Please help us spread the word—mentee applications are accepted until March 31st: shorturl.at/grUek

Two-photon brightness of NIR-emitting, atomically precise DNA-stabilized silver nanoclusters Near-infrared (NIR) emitters with high two-photon absorption (2PA) cross-sections are of interest to enable in vivo imaging in the tissue transparency windows. This study explores the potential of DNA...

Excited that our collaborative work with the Olesiak-Banska
group is published in Chemical Science!
pubs.rsc.org/en/content/a...
@roysocchem.bsky.social
@ps.uci.edu
@ucirvine.bsky.social

We are looking for a postdoc to join the Knight Group! Interested in the interface of peptide and polymer chemistry with applications in therapeutics and nanomaterials? Send questions or an application with a cover letter, CV, and statement of previous research. #chempostdoc

www.knightgroupunc.org

Amazing work from UC Irvine Chemistry @ps.uci.edu !

I'm so sorry for your loss, Rachel! 💔

Fully agree. "Reviewer 2" can be your best way to an even more insightful paper. Using LLMs to forge what is supposed to be your authentic review is just another form of academic dishonesty, imo.

I was infuriated recently by this exact thing for a "reputable ACS journal" but was actually the corresponding author... it was horrifying to think that my paper was not actually fairly reviewed with the scrutiny it should have been. Of course I could not prove this, but I'm 99% sure.

Symposium NM02-Atomic Precision in Nanocluster Engineering Step into the forefront of scientific discovery at the world’s leading international scientific gathering for materials research. Our annual fall event returns to the culturally-rich city of Boston, M...

Looking forward to kicking off the #F24MRS Symposium on Atomic Precision in Nanocluster Engineering tomorrow AM! Don't miss our great lineup of invited and contributed speakers!
www.mrs.org/meetings-eve...
@materials-mrs.bsky.social

This is very sad to see. :-(

Anna Gonzàlez-Rosell ‪PhD Candidate, University of California, Irvine‬ - ‪‪Cited by 229‬‬ - ‪soft materials‬ - ‪metal nanoclusters‬

Congratulations to Dr. Anna Gonzàlez Rosell, the latest PhD from from the Copplab! If you were not lucky enough to see her amazing defense, you can check out her research here: scholar.google.com/citations?us...

✨Anna Gonzalez Rosell's Dissertation Defense Information✨

Wednesday, November 20, 2024 @ 11:00 AM

In person, ISEB Room 4020
Virtually: uci.zoom.us/j/9217352864...
Meeting ID: 921 7352 8643, Passcode: 485040

The Copp lab has moved platforms! We are a nanomaterials chemistry and engineering group at UC Irvine, studying DNA nanotechnology, fluorescent nanoclusters, and self-assembly. #Chemistry #nanotech #fluorescence