Bassem Mohammed

I am still having a bit of hard time using 3D classification to separate a dimer ligand complex where one time the ligand is there on the symmetric subunit and sometime it is not there or have weak density.

Post Doctoral Fellow - Hemostasis & Thrombosis Who is Saint Louis University? Founded in 1818, Saint Louis University is one of the nation’s oldest and most prestigious Catholic universities. SLU, which also has a campus in Madrid, Spain, is recog...

We are building our team. Got a PhD on a cogualtion related topic. Come join us slu.wd5.myworkdayjobs.com/Careers/job/...

Cryo-EM structure of coagulation factor Va bound to activated protein C Coagulation factor Va (fVa) is the cofactor component of the prothrombinase complex required for rapid generation of thrombin from prothrombin in the …

Electrostatic handshake drive factor Va cleavage at R506 by Activated protein C.

👥 Meet the future of thrombosis and hemostasis research. In "Leading from the Start", we highlight the pivotal role of the ISTH SSC and its Early Career Co-Chairs—emerging leaders who are already making a global impact.

Read more here: bit.ly/3XOmNCI

If you missed our paper on the humanized murine model of VWD-type 1 (hVWD1) you can read it haematologica.org/article/view...
The model provides a novel platform to test therapeutic options for #VWD one of which is explored in the paper! Thanks Haematologica for the highlight as Editor’s pick!

Congrats to All JTH editor's Award recipients

1st attempt, please add to this 😊
go.bsky.app/Cph9GV4

Welcome @isth-official.bsky.social to 🦋!
To my followers: please follow ISTH for news, education, and community for #Thrombosis & #Hemostasis!
#HemeSky

We’ve extended the early (reduced-price) registration deadline for PolyP-2025, the conference on polyphosphate biology, until April 30!!

Please spread the word about this conference. We have a great lineup of speakers on this emerging field!

polyp2025.org/registration/

Fifth New York Area Cryo-EM Meeting | NYU Langone Health Join the 2025 Cryo-EM & Cryo-ET Meeting at NYU Langone! Share unpublished work, discuss breakthroughs, and tackle challenges. June 25. Register now!

Registration is now open for the 2025 NYC CryoEM meeting, organized by Bill Rice (NYU) & @fravallese.bsky.social (CUNY/ASRC)

Always a great meeting with lots of new #cryoem work by rising stars in/around NYC

Max 140 people so register now (it’s free)!

A Model of Zymogen Factor XII: Insights into Protease Activation Key Points. When not bound to a surface, FXII adopts a “closed” conformation that is resistant to activation by plasma kallikrein.Intramolecular interactio

Factor XII (FXII) exists in multiple conformations, with a "closed" form dominating in solution. Surface binding triggers a shift to an "open" form, more primed for activation. AlphaFold-guided studies and single-molecule dynamics shed light on this process!

ashpublications.org/bloodadvance...

Replacement of a single residue changes the primary specificity of thrombin - PubMed D189 in the S1 pocket confers thrombin "trypsin-like" specificity for Arg at P1. However, the S1 pocket is wide enough to also enable "chymotrypsin-like" specificity for Phe at P1. Consistent with the...

Single amino acid replacement can change thrombin substrate preference from trypsin-like to chymotrypsin-like pubmed.ncbi.nlm.nih.gov/39756655/

I am missing the registration link on the website.

Frankel Cardiovascular Center, University of Michigan Health

Call for Abstracts: PolyP-2025 – Conference on Polyphosphate Biology – May 20-23, 2025. Abstract deadline for oral or poster presentation is March 1; deadline for poster-only presentation is April 1. Early (reduced-cost) registration deadline is February 28, 2025. Full meeting info: polyp2025.org

Gave a talk on social media this morning at #ASH24

Someone asked about the longevity of BlueSky and I answered optimistically.

So don’t make me look dumb y’all.

We need to create a washu-slu listserv for those events.