Dementias Platform UK

DPUK’s focus: building “complex knowledge” — integrating imaging, genomics, biomarkers, trials and AI etc., within shared research architectures. Connecting these disciplines is a force multiplier for #dementia discovery. #DementiaResearch #TranslationalScience
zurl.co/oKkaN

Targeting toxic protein chains could slow neurodegenerative disease New research reveals that repetitive strings of the amino acid serine can kill brain cells and accelerate the formation of toxic tau tangles associated with Alzheimer’s disease.

Targeting toxic protein chains could slow neurodegenerative disease

flip.it/zefWMZ

DPUK is advancing cross-platform data federation with international partners, enabling secure analysis without data transfer. A practical solution to global collaboration while preserving governance standards. #DataFederation #OpenScience

zurl.co/mbRTe

DPUK's Trials Delivery Framework is the largest dementia-focused network in the UK, with participant registers and a UK-wide clinical network. Read more about the expanding reach and growing use of our resources in our latest Annual Report.
Download your copy now: zurl.co/TYthy

"Our progress has relied on developing a high trust, pre-competitive environment in which collaboration thrives." (Prof John Gallacher)
Read more about our science, resources & activities.
DPUK Annual Report 2025: Embracing Complexity.
zurl.co/uMVSw
#dementia #MCI #neurodegeneration

Download our 2025 Annual Report: Embracing Complexity
Data Portal, Trials Delivery, Experimental Medicine, Translational Research
zurl.co/9K8sY

#dementia #ageing #cognition #brain #neurdegeneration #healthdata #mnd #MRC #AI #imaging #genomics #biomarkers

The top tips dementia experts use to protect themselves Gill Livingston, a professor of psychiatry of older people at University College London says: 'Alcohol is a toxin that can affect memory and raise your dementia risk.'

Here's a really useful guide to dementia (Daily Mail & @alzheimerssoc.bsky.social)
Read Prof Vanessa Raymont's (DPUK) excellent guide to early signs of dementia which are so important to getting an early diagnosis and managing the disease.
zurl.co/BWukH

On World Lewy Body Dementia Day, we are highlighting 2 neuroimmunology studies from our team at the University of Cambridge: IMPRINT is looking at the onset of the disease; and IMPACT, investigating the role of brain inflammation in DLB with PET scanning. zurl.co/EhBs5

The last year saw record growth in applications to access data on our portal.

📈 169 applications from 19 countries.
📥 Over 550 individual data access requests
🙋🏽 Assisting 1,300 portal users

Find out what resources are available: zurl.co/w4846

At least 479 publications cite DPUK or have used our resources.
These are only the papers we know about.
Take a look at the research publication page on our website and scroll or search the list: zurl.co/Ytg9g

Another exciting blood biomarker study Bio-Hermes-002...Welcomed by Prof Vanessa Raymont DPUK's READ-OUT study/Blood Biomarker Challenge: “It's an opportunity for the comparison of very accessible markers with more validated markers such as PET imaging."
zurl.co/FvTvg

Help DPUK's #LACI-Cog study? It's testing 2 treatments for #vascular #cognitiveimpairment & #dementia in people with memory problems caused by damaged blood vessels in the #brain. Access the survey at #POPPED, the PPIE site zurl.co/17YET. Anyone can complete it.

We are looking for people to take a short survey online to find the best approach to supporting people taking an APOE4 test. You don't need to have a diagnosis. You could be a carer or work in research or the NHS. Read about the survey here: zurl.co/C9wCH

📚 340+ publications enabled or cited DPUK in the last 5 years
Our reach is broad. Our impact is real.
From data infrastructure to research collaborations - we're supporting discoveries that matter.
#DementiaResearch #ResearchImpact #DPUK

🤖 NEW REPORT: AI in Sensitive Healthcare Data
Our data team @SwanseaUni with @DAREuk produced this vital report on unique challenges of complex multi-modal data in health research.
Download: zurl.co/qTFI0
#AI #HealthData #DPUK

🧠 300,000+ neuroimaging scans on our Data Portal
Pre-loaded analysis tools. Growing all the time.
Researchers: Check our Imaging Matrix to see what's available 👇
zurl.co/Ww377
#Neuroimaging #DementiaResearch #DPUK

🎯 72,000 people in our Trials Delivery Framework registers
Trial & study researchers can access Great Minds and CSR - pre-clinical dementia registers totalling 72,000 people.
Accelerating recruitment = accelerating discoveries.
#ClinicalTrials #DementiaResearch #DPUK

🎉 500 participants recruited to READ-OUT in its first year!
#DPUK blood biomarker study launched in January and already hit this incredible milestone.
Our volunteers are helping identify blood tests for dementia to roll out across the NHS. #DementiaResearch #Biomarkers

🚀 2,000 recruits to our FAST study!
Assessing feasibility & accessibility of blood tests for dementia through data & samples from people over 50 - cognitively healthy or with MCI.
Building the evidence base for next-gen diagnostics.
#DementiaResearch #ClinicalTrials #DPUK

🌍 Find dementia data sources globally
Our searchable Data Landscape Report covers:
📊 Clinical Trials
🧠 Dementia Datasets
👥 Research Registers Worldwide.
Explore: zurl.co/2MWPR
#OpenData #DementiaResearch #DPUK

Welcome

🧠 13,500+ people on our Great Minds Register!
Highly characterised volunteers ready to join health studies and accelerate dementia research.
Want to make a difference? Join Great Minds 👇
zurl.co/4grwF
#DementiaResearch #GreatMinds #DPUK

📈 Delivering for dementia research!
15% increase in study applications for our Data Portal this year. More researchers = more discoveries.
(Except when COVID struck - we don't talk about that year 😉)
#DementiaResearch #OpenScience #DPUK

Digital cognitive remediation therapy #DCRT offers a scalable, accessible intervention for #MCI or #dementia, for settings with limited clinical resources. It compares with conventional #CRT. Long-term and functional impacts remain uncertain.
READ MORE zurl.co/cXSvy

Thanks Alex McCreadie (+ 499 others). He's our 500th recruit to our #READ-OUT study - evaluating tests diagnosing #dementia to use in the #NHS, for the Blood Biomarker Challenge run by @alzheimersresearchuk.org & @alzheimerssoc.bsky.social. Recruited by @ReMind_UK in Bath. #MCI #ageing #brainhealth

What next for GLP-1 receptor agonists and dementia?
So, semaglutide didn't slow cognitive decline in early Alzheimer's, but there were positive outcomes. Read Ivan Koychev's reflections. zurl.co/PaL1s
#DementiaResearch #AlzheimersResearch #ClinicalTrials #Prevention #DPUK #GLP1

#DPUK has groundbreaking #dementia studies in our Experimental Medicine Incubator. We’re running 7 randomised trials and 31 observational studies.

Our work could be key to better treatment in future." – Prof. James Rowe, Cambridge University

Read more zurl.co/iVIQS

Dementia is now the UK's most feared illness, reports @Telegraph. At #DPUK, we understand the urgency. We're accelerating research by connecting scientists with crucial data to develop better treatments. Together, we can change the future. zurl.co/st2Ee #BrainHealth

Charting the Ageing Brain: Insights from 46,000 MRI Scans What happens inside our brains as we age? Researcher Fatemeh (Simeen) Tabassi Mofrad used UK Biobank data to create an unprecedented map of brain ageing—and discovered why some regions are more vulnerable than others.

🧠 What happens inside our brains as we age?

Researcher Fatemeh (Simeen) Tabassi Mofrad analysed 46,000+ MRI scans to map brain ageing—revealing why some regions are more vulnerable than others.

Discover the findings 👉 zurl.co/AAoSv

#DementiaResearch #BrainHealth #UKBiobank

Thrilled that biomarker pilot project, delivered with Eli Lilly & Company and 4 NHS trusts, has won the prestigious @HSJ_Awards Partnership of the Year Award 2025! The project aims to transform early diagnosis of #Alzheimer’s disease by testing the scalability of biomarker diagnostics.

We’re thrilled our cross-sector project to improve Alzheimer’s diagnosis, a partnership between Dementias Platform UK , Eli Lilly UK & Ireland, and four NHS Trusts, has been shortlisted for the 2025 HSJ Partnership of the Year Award, recognising healthcare innovation in the UK.