Alan McNally

How do bacterial pangenomes evolve, what controls their dynamics, why do they exist?
Fitting a mechanistic model to 450 species from allthebacteria.org suggesting fast vs slow gene exchange (i.e. amount of MGEs) is a major differentiating factor, correlated with phylogeny rather than lifestyle

At long last, my final PhD chapter is out: we developed a novel evolutionary simulator of bacterial pangenomes, Pansim, fitting it to data from >600K genomes using a likelihood-free framework, PopPUNK-mod, to explore neutral and adaptive pangenome dynamics www.biorxiv.org/content/10.6...

As good as the 85 Bears. Just an incredible defensive display

Finally

Kenneth Walker winning the superbowl

If this guy was in the back garden I would shut the blinds.

Not a classic for the ages

Pregame celebrating America being 250 years old

The church in our village is 980 years old…………

Without naming your job, tell me something you say over and over again at work

“Oh for fucks sake”

Nailing my colours to the mast now. Go Seahawks!!!!

He looks like the notepad next to the landline.

Watched enough of this shite. Newcastle game it is

Christ this is dreadful. It’s like U18s versus U12s!!!!!

He should have gone 2 world cups ago. This is reminiscent of his final days as Glasgow coach; over coaching everything and trying to knock a square peg in a round hole. Did no one in Scotland check what the weather forecast was?!

I think we can all agree that Graham, Kinghorn and Van der Merwe start for Scotland

This is a diabolical, ill disciplined shambles of a performance

Oh FFS

BLAZING SADDLES was released 52 years ago today. Acclaimed as one of the great comedies of the 1970s, and among the most popular of director Mel Brooks, the story of how it was made is a cascading waterfall of creative alternatives...

1/36

Registration fee is only 175€, some of the invited speakers: Charles Rice, Yasmine Belkaid, Bonnie Bassler, Daniel Mucida, Joy Bergelson, Matthew Chang, Carolina Lucas, Jeff Barrick, Carolina Tropini, Roy Kishony and more... Save the date now!

Sometimes I'm late because I sit like this for too long instead of getting ready.

"No I'm fine, you just make sure you get your fucking video first"

Relax. Just the rugby lol

a group of cartoon characters are standing in front of a christmas tree and looking surprised . ALT: a group of cartoon characters are standing in front of a christmas tree and looking surprised .

Paris. Now.

MRC funding update An update on MRC funding during UKRI’s transition, what’s changing, and the next steps for paused opportunities and reopening timelines.

Finally an official update from #MRC regarding grant application funding and severe cuts to funded research in rounds currently under review:
www.ukri.org/blog/mrc-fun...

Not that it gives any reassurance or details beyond a comprehensive list of what is suspended.

#UKsciencefunding

Interested in eco-evolutionary feedbacks? Microbial experimental evolution? Pleiotropy? Filamentous phages??

Check out our latest preprint, now up on BioRxiv!

biorxiv.org/content/10.6...

For a quick summary, peep the thread below...🧵 (1/10)

Just sayin’.

Accurate plasmid reconstruction from metagenomics data using assembly–alignment graphs and contrastive learning - Nature Biotechnology PlasMAAG uses cross-sample information to improve plasmid reconstruction from metagenomic samples.

Accurate plasmid reconstruction from metagenomics data using assembly–alignment graphs and contrastive learning www.nature.com/articles/s41... #jcampubs

WHAT A con these so-called "notebooks" are. They're just books without any words, and yet most of them cost much more than best-selling novels. If I was an author, I'd just be sending blank pages to my publisher and going down the pub. lan Shakespeare, Funtingdon-on-the-Funt

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